INT78444

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Context Info
Confidence 0.16
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.82
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1, IGF1) extracellular region (GH1, IGF1) signal transduction (IGF1)
Anatomy Link Frequency
body 1
GH1 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 99.88 Very High Very High Very High
imagery 2 83.84 Quite High
Osteoarthritis 1 67.08 Quite High
cytokine 2 64.96 Quite High
headache 5 62.44 Quite High
Inflammatory marker 4 50.00 Quite Low
agonist 43 21.04 Low Low
Dopamine 44 5.00 Very Low Very Low Very Low
Somatostatin 32 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 99.80 Very High Very High Very High
Thyroid Disease 2 98.56 Very High Very High Very High
Liver Disease 1 97.92 Very High Very High Very High
Acromegaly 36 96.84 Very High Very High Very High
Hypoglycemia 4 96.80 Very High Very High Very High
Disease 64 96.72 Very High Very High Very High
Congenital Anomalies 4 94.84 High High
Cancer 58 90.16 High High
Recurrence 7 77.44 Quite High
Syndrome 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 were low (5.2 +/- 2.0 ng/mL and 0.42 +/- 0.13 microg/mL, respectively; mean +/- SD) but rose normally with GH treatment.
GH Binding (rose) of Insulin-like growth factor I
1) Confidence 0.16 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9814493 Disease Relevance 0.48 Pain Relevance 0.10
Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 were low (5.2 +/- 2.0 ng/mL and 0.42 +/- 0.13 microg/mL, respectively; mean +/- SD) but rose normally with GH treatment.
GH Binding (rose) of IGF-I
2) Confidence 0.16 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9814493 Disease Relevance 0.48 Pain Relevance 0.10
In conjunction with GH, IGF-I has varying differential effects on protein, glucose, lipid and calcium metabolism and therefore body composition (Mauras et al 2000).
GH Binding (conjunction) of IGF-I in body
3) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.47 Pain Relevance 0.07
g/L after an oral glucose load using a sensitive GH assay, and IGF-1 levels within the normal age- and sex-adjusted range [83].
GH Binding (assay) of IGF-1
4) Confidence 0.03 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 1.39 Pain Relevance 0.10

General Comments

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