INT78467

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.29
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
plasma 5
monocytes 1
THP-1 1
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 266 99.84 Very High Very High Very High
rheumatoid arthritis 112 95.80 Very High Very High Very High
psoriasis 35 95.80 Very High Very High Very High
Arthritis 108 95.24 Very High Very High Very High
aspirin 9 91.96 High High
Opioid 7 91.76 High High
chemokine 5 89.52 High High
cINOD 7 87.88 High High
abatacept 2 86.20 High High
Angina 2 82.80 Quite High
Disease Link Frequency Relevance Heat
Celiac Disease 58 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 59 99.82 Very High Very High Very High
Salmonella Infection 11 99.70 Very High Very High Very High
Disease 204 98.84 Very High Very High Very High
Infection 232 97.88 Very High Very High Very High
Hepatitis C Virus Infection 117 97.48 Very High Very High Very High
Cancer 219 96.96 Very High Very High Very High
Opiate Addiction 79 96.68 Very High Very High Very High
Psoriasis 45 96.56 Very High Very High Very High
Rheumatoid Arthritis 112 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.
Negative_regulation (evaluation) of interleukin 12
1) Confidence 0.38 Published 1997 Journal Clin. Cancer Res. Section Title Doc Link 9815699 Disease Relevance 1.03 Pain Relevance 0.05
Addition of IL-18BP could decrease the IL-12-induced IFN-?
Negative_regulation (decrease) of IL-12-induced
2) Confidence 0.28 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.97 Pain Relevance 0.48
SOCS-3 has been reported to be a negative regulator of IL-12 signaling by preventing STAT-4 binding to the IL-12R?
Negative_regulation (regulator) of IL-12
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.22 Pain Relevance 0
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of IL-12 in monocytes
4) Confidence 0.19 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.37
A significant downregulation of IL-12 and IL-10 in the plasma, elevation of IFN-?
Negative_regulation (downregulation) of IL-12 in plasma
5) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.19 Pain Relevance 0.05
were elevated during active disease (Table 2). 1-week after treatment, there was significant downregulation of IL-12 and IL-10 (P<0.005) in the responders compared to untreated condition, however, there was no significant change in the levels of IFN-?
Negative_regulation (downregulation) of IL-12 associated with disease
6) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.53 Pain Relevance 0.17
Finally, therapies directed at inhibiting IL-12, a cytokine central in driving Th1 biased immune responses, are in the early phases of investigation in psoriasis and PsA.



Negative_regulation (inhibiting) of IL-12 associated with psoriasis, arthritis and cytokine
7) Confidence 0.15 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.82 Pain Relevance 0.46
In this connection, we investigated the functionality of IL-12R on in vitro expanded NBEC since immunohistochemical studies disclosed IL-12R?
Negative_regulation (disclosed) of IL-12R
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.85 Pain Relevance 0.14
Patients successfully cured demonstrated downregulation of IL-12 and IL-10 in plasma, and two-fold or more elevation of IFN-?
Negative_regulation (downregulation) of IL-12 in plasma
9) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.23 Pain Relevance 0.08
A differential immune profile, involving insignificant decline in IL-10 and IL-12 in plasma and negligible elevation of IFN-?
Negative_regulation (decline) of IL-12 in plasma
10) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.30 Pain Relevance 0.07
Successfully cured patients showed reduced IL-12 and IL-10 levels in the plasma and two-fold or more increase in Th1 type-cytokines IFN-?
Negative_regulation (reduced) of IL-12 in plasma associated with cytokine
11) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.73 Pain Relevance 0.17
Promising strategies in murine SLE include inhibition of IL-12, -17, -18, -21 and -23, which may have translatable effects in humans.
Negative_regulation (inhibition) of IL-12 associated with systemic lupus erythematosus
12) Confidence 0.10 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 1.16 Pain Relevance 0.25
Negligible decline in plasma IL-12 and IL-10 levels, negligible elevation of IFN-?
Negative_regulation (decline) of IL-12 in plasma
13) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.17 Pain Relevance 0.04
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Negative_regulation (inhibited) of IL-12 in THP-1
14) Confidence 0.06 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
R) genes, both inhibitors of IL-12 and INF-?
Negative_regulation (inhibitors) of IL-12
15) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.61 Pain Relevance 0.13
In an investigation by deJong et al. [61], three unrelated individuals with severe, idiopathic mycobacterial and Salmonella infections were found to lack IL-12R?
Negative_regulation (lack) of IL-12R associated with salmonella infection
16) Confidence 0.02 Published 2006 Journal J Transl Med Section Body Doc Link PMC1479838 Disease Relevance 0.98 Pain Relevance 0.12
The risk of extra-intestinal nontyphoidal salmonellosis is higher in patients with impaired cell mediated immunity, lympho-proliferative disorders and IL-12 deficiencies.
Negative_regulation (deficiencies) of IL-12 associated with salmonella infection
17) Confidence 0.02 Published 2008 Journal Cases J Section Abstract Doc Link PMC2614946 Disease Relevance 0.94 Pain Relevance 0.08
Since IL-12, a major promoter of Th1 differentiation, is absent in celiac sprue [92], other cytokines must mediate this Th1 differentiation.
Negative_regulation (absent) of IL-12 associated with celiac disease and cytokine
18) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.32 Pain Relevance 0.17

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