INT7847

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
pancreas 2
cortex 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 14 100.00 Very High Very High Very High
Hippocampus 4 98.68 Very High Very High Very High
Neurotransmitter 1 80.24 Quite High
agonist 3 79.36 Quite High
antagonist 4 63.08 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 89.12 High High
Hypoxia 1 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha-2 adrenergic agonism stimulates islet glucagon release from perfused rat pancreas: possible involvement of alpha-2A adrenergic receptor subtype.
Positive_regulation (stimulates) of Localization (release) of alpha-2A in pancreas
1) Confidence 0.40 Published 1992 Journal Acta Endocrinol. Section Title Doc Link 1357904 Disease Relevance 0 Pain Relevance 0.33
In contrast, alpha2-adrenergic receptors were increased in cortex for both CLO and SCO, decreased in hypothalamus for CLO, and decreased in hippocampus for SCO (p<0.05 for each).
Positive_regulation (increased) of Localization (decreased) of alpha2-adrenergic in cortex associated with hippocampus and clonidine
2) Confidence 0.05 Published 2000 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10775770 Disease Relevance 0.22 Pain Relevance 0.95

General Comments

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