INT78470

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 22
Disease Relevance 14.44
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
pancreas 2
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 1 99.98 Very High Very High Very High
Chronic pancreatitis 15 99.42 Very High Very High Very High
COX2 2 84.56 Quite High
Opioid 2 75.00 Quite High
palliative 16 68.48 Quite High
Enkephalin 1 63.28 Quite High
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 469 99.96 Very High Very High Very High
Pancreatic Cancer 84 99.56 Very High Very High Very High
Lifespan 32 99.46 Very High Very High Very High
Pancreatitis 18 99.42 Very High Very High Very High
Malignant Neoplastic Disease 35 99.40 Very High Very High Very High
Cystadenoma 4 99.40 Very High Very High Very High
Aging 151 98.96 Very High Very High Very High
Apoptosis 22 98.92 Very High Very High Very High
Colorectal Cancer 50 98.20 Very High Very High Very High
Carcinoma 32 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of p16 protein expression was noted in 18 out of 25 tumors as determined by immunohistochemistry.
Negative_regulation (Loss) of Gene_expression (expression) of p16 associated with cancer
1) Confidence 0.59 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.39 Pain Relevance 0
Moreover, loss of p16 expression in pancreatic malignancy was significantly associated with histological grade (G1 versus G2 and G3, P < 0.01) but not with sex, age, clinical stage, tumor location, or resectability.
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with malignant neoplastic disease and cancer
2) Confidence 0.58 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.80 Pain Relevance 0.19
Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with pancreatic cancer
3) Confidence 0.58 Published 1997 Journal Clin. Cancer Res. Section Title Doc Link 9815833 Disease Relevance 0.73 Pain Relevance 0.16
All six cases of normal pancreas and all but 1 of 20 cases of chronic pancreatitis expressed p16 protein, whereas 37.5% (3 of 8) of cystadenomas and 41. 9% (26 of 62) of PCs lost p16 expression.
Negative_regulation (lost) of Gene_expression (expression) of p16 in pancreas associated with cystadenoma and chronic pancreatitis
4) Confidence 0.58 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.79 Pain Relevance 0.19
There was a significant difference between chronic pancreatitis and PC for frequency of the loss of p16 expression (P < 0.01).
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.58 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.80 Pain Relevance 0.19
CBX7, another PcG protein, shares no homology with Bmi-1 but was found to have similar functions and mechanisms as Bmi-1 that inhibits cellular senescence and extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF locus, and cooperates with c-Myc in lymphomagenesis [7,8,11].
Negative_regulation (downregulating) of Gene_expression (expression) of INK4a associated with aging and lifespan
6) Confidence 0.57 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.87 Pain Relevance 0
Blockade of OGF-OGFr interactions with naloxone abolished the increased expression of p16 protein by OGF.
Negative_regulation (abolished) of Gene_expression (expression) of p16 associated with narcan
7) Confidence 0.55 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.21 Pain Relevance 0.25
Inactivation of tumor suppressor gene CDKN2A (p16) cyclin dependent kinase inhibitor occurs later and the loss of expression of the p16 gene could be correlated with the severity of cytological and architectural atypia [62].
Negative_regulation (loss) of Gene_expression (expression) of p16 associated with cancer
8) Confidence 0.50 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 0.85 Pain Relevance 0.09
On the other hand, two of these mutations resulted in a loss of p16 protein expression and so, it may be postulated that they could have affected the stability and half life of the mRNA or protein.
Negative_regulation (loss) of Gene_expression (expression) of p16
9) Confidence 0.43 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.08 Pain Relevance 0
The discrepancy could be due to the limited number of samples in our study, or other co-exist genes regulating p16(INK4a) and promoter methylation induced loss of p16(INK4a) expression might interfere and influence the results of correlation analysis.
Negative_regulation (loss) of Gene_expression (expression) of p16
10) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.94 Pain Relevance 0
It was found that CBX7 shares some similarities in functions and mechanisms with Bmi-1 including inhibiting cellular senescence and extending the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus [17,20,21].
Negative_regulation (downregulating) of Gene_expression (expression) of INK4a associated with aging, cancer and lifespan
11) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.06 Pain Relevance 0
Immunohistochemical (IHC) analyses to detect the expression of CBX7, and p16(INK4a) in paraffin sections were performed as described [19].
Negative_regulation (detect) of Gene_expression (expression) of p16
12) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.36 Pain Relevance 0.14
Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus.
Negative_regulation (downregulating) of Gene_expression (expression) of ARF associated with cancer and lifespan
13) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2933612 Disease Relevance 0.75 Pain Relevance 0
It was found that CBX7 shares some similarities in functions and mechanisms with Bmi-1 including inhibiting cellular senescence and extending the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus [17,20,21].
Negative_regulation (downregulating) of Gene_expression (expression) of ARF associated with aging, cancer and lifespan
14) Confidence 0.41 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.06 Pain Relevance 0
CBX7, another PcG protein, shares no homology with Bmi-1 but was found to have similar functions and mechanisms as Bmi-1 that inhibits cellular senescence and extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF locus, and cooperates with c-Myc in lymphomagenesis [7,8,11].
Negative_regulation (downregulating) of Gene_expression (expression) of ARF associated with aging and lifespan
15) Confidence 0.41 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.92 Pain Relevance 0
In noncarcinoma patients (n = 23), 8.7% exhibited p16 deletions.
Negative_regulation (exhibited) of Gene_expression (deletions) of p16
16) Confidence 0.38 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.24 Pain Relevance 0
Detection of homozygous deletion in p16INK4a
Negative_regulation (deletion) of Gene_expression (Detection) of p16INK4a
17) Confidence 0.37 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.73 Pain Relevance 0
Immunohistochemical (IHC) analyses to detect the expression of CBX7, and p16(INK4a) in paraffin sections were performed as described [19].
Negative_regulation (detect) of Gene_expression (expression) of INK4a
18) Confidence 0.36 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.36 Pain Relevance 0.14
Subsequent experiments showed that Chd5 mediated apoptosis involved p53 and that Chd5 haploinsufficiency led to decreased expression of CDKN2A (p16) and p19 (human p14ARF-alternate-spliced exon 1?
Negative_regulation (decreased) of Gene_expression (expression) of CDKN2A associated with apoptosis
19) Confidence 0.36 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.80 Pain Relevance 0
Subsequent experiments showed that Chd5 mediated apoptosis involved p53 and that Chd5 haploinsufficiency led to decreased expression of CDKN2A (p16) and p19 (human p14ARF-alternate-spliced exon 1?
Negative_regulation (decreased) of Gene_expression (expression) of p16 associated with apoptosis
20) Confidence 0.36 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.80 Pain Relevance 0

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