INT78472

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2011
Negated 5
Speculated 12
Reported most in Body
Documents 223
Total Number 235
Disease Relevance 173.76
Pain Relevance 13.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
epithelial cell 6
blood 4
vulva 4
lymph node 3
telomere 3
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 961 100.00 Very High Very High Very High
metalloproteinase 221 100.00 Very High Very High Very High
opioid receptor 20 100.00 Very High Very High Very High
Chronic pancreatitis 54 99.98 Very High Very High Very High
narcan 11 99.50 Very High Very High Very High
Dismenorea 12 98.88 Very High Very High Very High
Pain 78 97.16 Very High Very High Very High
cytokine 390 96.60 Very High Very High Very High
Osteoarthritis 133 96.48 Very High Very High Very High
antagonist 50 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 6043 100.00 Very High Very High Very High
Aging 3122 100.00 Very High Very High Very High
Acute Renal Failure 576 100.00 Very High Very High Very High
Skin Cancer 383 100.00 Very High Very High Very High
Retinoblastoma 121 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 14 100.00 Very High Very High Very High
Adenocarcinoma 1229 99.98 Very High Very High Very High
Pancreatitis 75 99.98 Very High Very High Very High
Papillomavirus Infection 725 99.90 Very High Very High Very High
Pancreatic Cancer 559 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of p16 protein expression was noted in 18 out of 25 tumors as determined by immunohistochemistry.
Gene_expression (expression) of p16 associated with cancer
1) Confidence 0.78 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.39 Pain Relevance 0
In 2 out of 18 tumors negative for p16 protein expression, we were unable to detect any genetic alteration in the form of deletion, mutation or promoter hypermethylation.
Gene_expression (expression) of p16 associated with cancer
2) Confidence 0.78 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.10 Pain Relevance 0
The survival period was shorter and metastasis is more likely in those cases that did not show p16 expression than those that did.
Gene_expression (expression) of p16 associated with metastasis
3) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.82 Pain Relevance 0.16
There was a significant difference between chronic pancreatitis and PC for frequency of the loss of p16 expression (P < 0.01).
Gene_expression (expression) of p16 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.80 Pain Relevance 0.19
All six cases of normal pancreas and all but 1 of 20 cases of chronic pancreatitis expressed p16 protein, whereas 37.5% (3 of 8) of cystadenomas and 41. 9% (26 of 62) of PCs lost p16 expression.
Gene_expression (expressed) of p16 in pancreas associated with cystadenoma and chronic pancreatitis
5) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.77 Pain Relevance 0.19
Expression of the p16 gene product in human primary pancreatic carcinoma (PC) was investigated in paraffin-embedded tissue using a monoclonal antibody against p16 protein, clone G175-405, by means of immunohistochemistry, and the correlation of results with various clinicopathological parameters was evaluated.
Spec (investigated) Gene_expression (Expression) of p16 associated with pancreatic cancer
6) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.52 Pain Relevance 0.13
Moreover, loss of p16 expression in pancreatic malignancy was significantly associated with histological grade (G1 versus G2 and G3, P < 0.01) but not with sex, age, clinical stage, tumor location, or resectability.
Gene_expression (expression) of p16 associated with malignant neoplastic disease and cancer
7) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.80 Pain Relevance 0.19
Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.
Gene_expression (expression) of p16 associated with pancreatic cancer
8) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Title Doc Link 9815833 Disease Relevance 0.73 Pain Relevance 0.16
All six cases of normal pancreas and all but 1 of 20 cases of chronic pancreatitis expressed p16 protein, whereas 37.5% (3 of 8) of cystadenomas and 41. 9% (26 of 62) of PCs lost p16 expression.
Gene_expression (expression) of p16 in pancreas associated with cystadenoma and chronic pancreatitis
9) Confidence 0.77 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815833 Disease Relevance 0.79 Pain Relevance 0.19
Expression and localisation of P16INK4A
Gene_expression (Expression) of P16INK4A
10) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.10 Pain Relevance 0
No gene expression for p16INK4a, MMP-13, or ADAMTS 5 was observed in directly extracted NP cells from non-degenerate discs, but expression for these genes was seen in NP cells directly extracted from degenerate discs (average: p16INK4a, 1,893 copies/100 ng of cDNA; MMP-13, 9,386 copies/100 ng of cDNA; ADAMTS 5, 21,220 copies/100 ng of cDNA).


Gene_expression (expression) of p16INK4a
11) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.30 Pain Relevance 0
CBX7 was detected by using a rabbit polyclonal antibody from Abcam (Cambridge, UK), and p16(INK4a) was detected by a mouse monoclonal JC8 (Santa Cruz Biotech, CA).
Gene_expression (detected) of p16
12) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.45 Pain Relevance 0.16
In the present study we found that knockdown of CBX7 resulted in increased p16(INK4a) expression and was accompanied by decreased transformed phenotype and migration ability, which suggested regulation of p16(INK4a) might be one of the important mechanisms of CBX7 in gastric cancer.
Gene_expression (expression) of p16 associated with stomach cancer
13) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.83 Pain Relevance 0
Western blot analyses to detect the expression of CBX7, p16(INK4a), and ?
Gene_expression (expression) of p16
14) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.44 Pain Relevance 0.15
Immunohistochemical (IHC) analyses to detect the expression of CBX7, and p16(INK4a) in paraffin sections were performed as described [19].
Gene_expression (expression) of p16
15) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.36 Pain Relevance 0.13
CBX7, another PcG protein, shares no homology with Bmi-1 but was found to have similar functions and mechanisms as Bmi-1 that inhibits cellular senescence and extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF locus, and cooperates with c-Myc in lymphomagenesis [7,8,11].
Gene_expression (expression) of INK4a associated with aging and lifespan
16) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.87 Pain Relevance 0
However, multivariate Cox proportional hazards model analyses, which included age, lymph node metastasis, distant metastasis, clinical stage, CBX7 protein expression and p16(INK4a) protein expression, showed that only lymph node metastasis was an independent prognostic indicator of overall survival, while CBX7 wasn't the independent prognostic indicator (Table 2).


Gene_expression (expression) of p16 in lymph node associated with metastasis
17) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.88 Pain Relevance 0
It was found that CBX7 shares some similarities in functions and mechanisms with Bmi-1 including inhibiting cellular senescence and extending the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus [17,20,21].
Gene_expression (expression) of INK4a associated with aging, cancer and lifespan
18) Confidence 0.76 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.05 Pain Relevance 0
Moreover, in adenomyosis samples positive for p16, 100% of the adenomyotic cells expressed p16, whereas only 10%-20% of endometriosis cells from positive cases expressed p16.
Gene_expression (expressed) of p16
19) Confidence 0.76 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616093 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: To investigate the expression of p16, retinoblastoma (pRb), and cyclin D1 oncoproteins in endometriomas and adenomyosis.
Spec (investigate) Gene_expression (expression) of p16 associated with endometriosis, dismenorea and retinoblastoma
20) Confidence 0.76 Published 2006 Journal Fertil. Steril. Section Abstract Doc Link 16616093 Disease Relevance 0.52 Pain Relevance 0.17

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