INT78473

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL3) extracellular region (IL3) cell-cell signaling (IL3)
Anatomy Link Frequency
neutrophils 3
eosinophils 1
IL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 2 73.56 Quite High
cytokine 4 71.76 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 2 75.00 Quite High
Headache 2 73.56 Quite High
Diarrhoea 2 72.44 Quite High
Toxicity 6 71.56 Quite High
Myalgia 2 70.60 Quite High
Fever 2 70.08 Quite High
Chills 2 69.80 Quite High
Cancer 2 51.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacokinetic studies were performed in 13 patients, and area under the curve and maximal concentration values increased with increasing rhIL-3 dose levels (P < 0.001) and correlated with maximal changes from baseline in WBC, neutrophils, and eosinophils. rhIL-3 antibodies were detected in 8% of patients by day 29 of cycle 1 but were not neutralizing. rhIL-3 is well tolerated when administered s.c. and has reproducible hematological and immunological effects.
Positive_regulation (increased) of Positive_regulation (increasing) of rhIL-3 in neutrophils
1) Confidence 0.50 Published 1996 Journal Clin. Cancer Res. Section Abstract Doc Link 9816178 Disease Relevance 0.62 Pain Relevance 0.13
Pharmacokinetic studies were performed in 13 patients, and area under the curve and maximal concentration values increased with increasing rhIL-3 dose levels (P < 0.001) and correlated with maximal changes from baseline in WBC, neutrophils, and eosinophils. rhIL-3 antibodies were detected in 8% of patients by day 29 of cycle 1 but were not neutralizing. rhIL-3 is well tolerated when administered s.c. and has reproducible hematological and immunological effects.
Positive_regulation (increased) of in eosinophils Positive_regulation (increasing) of rhIL-3 in neutrophils
2) Confidence 0.17 Published 1996 Journal Clin. Cancer Res. Section Abstract Doc Link 9816178 Disease Relevance 0.62 Pain Relevance 0.13

General Comments

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