INT78479

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
pyramidal cells 2
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Hippocampus 3 100.00 Very High Very High Very High
corticosteroid 3 99.90 Very High Very High Very High
Delta opioid receptors 1 98.82 Very High Very High Very High
opioid receptor 7 98.28 Very High Very High Very High
Ultiva 9 97.92 Very High Very High Very High
Perioperative pain 2 97.58 Very High Very High Very High
Pyramidal cell 1 96.56 Very High Very High Very High
Spinal cord 3 87.20 High High
Pain 2 86.20 High High
Disease Link Frequency Relevance Heat
Frailty 1 100.00 Very High Very High Very High
Convulsion 1 100.00 Very High Very High Very High
Herpes Simplex Virus 1 99.66 Very High Very High Very High
Nociception 5 99.40 Very High Very High Very High
Injury 6 97.60 Very High Very High Very High
Post Operative Pain 2 97.58 Very High Very High Very High
Syndrome 1 92.80 High High
Repression 2 92.44 High High
Amnesia 3 91.60 High High
Pain 2 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trauma-induced memory deficits appear to be secondary to abnormal neocortical and hippocampal arousal, and corticosteroid and enkephalin secretion which can induce atrophy or seizures within the hippocampus, suppress hippocampal theta activity and long term potentiation, as well as injure hippocampal pyramidal cells.
Negative_regulation (suppress) of Localization (secretion) of enkephalin in pyramidal cells associated with corticosteroid, convulsion, pyramidal cell, frailty, injury, hippocampus and enkephalin
1) Confidence 0.43 Published 1998 Journal Child Psychiatry Hum Dev Section Abstract Doc Link 9816735 Disease Relevance 1.21 Pain Relevance 0.61
Using a mouse model of postoperative pain, we assessed the expression of MOR and delta opioid receptors (DORs) and the efficacy of Herpes Simplex vector-mediated proenkephalin release (SHPE) preventing postoperative nociceptive sensitization induced by remifentanil or surgical incision.
Negative_regulation (preventing) of Localization (release) of proenkephalin associated with nociception, herpes simplex virus, ultiva, delta opioid receptors, opioid receptor and perioperative pain
2) Confidence 0.42 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 0.68 Pain Relevance 1.19

General Comments

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