INT78487

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Context Info
Confidence 0.73
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SSR1) translation (SSR1)
SSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 35 100.00 Very High Very High Very High
5HT 11 100.00 Very High Very High Very High
noradrenaline 25 98.36 Very High Very High Very High
antidepressant 22 97.96 Very High Very High Very High
Serotonin 15 94.92 High High
depression 35 92.96 High High
fluoxetine 4 86.84 High High
addiction 1 75.88 Quite High
sNRI 2 53.68 Quite High
tricyclic antidepressant 2 52.80 Quite High
Disease Link Frequency Relevance Heat
Depression 40 92.96 High High
Disease 2 72.72 Quite High
Diabetes Mellitus 1 60.00 Quite High
Hypertension 1 59.48 Quite High
Cognitive Disorder 2 42.96 Quite Low
Fatigue 2 40.12 Quite Low
Obesity 1 39.76 Quite Low
Pain 1 37.76 Quite Low
Cardiovascular Disease 1 21.68 Low Low
Mental Disorders 1 16.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these patients, depending on the selective serotonin reuptake inhibitor (SSRI) used, it is recommended to adapt the dose of the antidepressant: Lower doses should be used for citalopram, paroxetine and probably also for sertraline, when therapy is initiated.
Localization (selective) of SSRI associated with antidepressant and ssri
1) Confidence 0.73 Published 1998 Journal Int Clin Psychopharmacol Section Abstract Doc Link 9817619 Disease Relevance 0.22 Pain Relevance 0.63
They demonstrate a range of affinities, from selectivity for 5HT (SSRIs), via compounds with affinity for both NA and 5HT, to those that are selective for NA.
Localization (selectivity) of SSRI associated with noradrenaline, 5ht and ssri
2) Confidence 0.73 Published 2008 Journal Trials Section Body Doc Link PMC2426669 Disease Relevance 0.73 Pain Relevance 1.06

General Comments

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