INT78493

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 8.35
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
Plasma 3
platelet 2
monocytes 1
chest 1
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 69 100.00 Very High Very High Very High
cytokine 2 88.92 High High
aspirin 7 77.28 Quite High
adenocard 1 70.44 Quite High
ergotamine 1 60.52 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 57 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 12 99.04 Very High Very High Very High
Thrombosis 14 98.32 Very High Very High Very High
Acute Coronary Syndrome 19 98.08 Very High Very High Very High
Myocardial Infarction 19 97.72 Very High Very High Very High
Cardiovascular Disease 25 97.04 Very High Very High Very High
Thrombophilia 6 96.56 Very High Very High Very High
Rupture 6 93.72 High High
Atherosclerotic Plaque 5 91.00 High High
Hypertension 4 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent basic studies focus on the therapeutic inhibition of tissue factor.
Negative_regulation (inhibition) of tissue factor
1) Confidence 0.27 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.78 Pain Relevance 0.06
Specific and non-specific inhibitors of tissue factor or the tissue factor/factor VIIa complex have been developed or identified, and have been tested in experimental studies.
Negative_regulation (inhibitors) of tissue factor
2) Confidence 0.23 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.77 Pain Relevance 0.06
Specific and non-specific inhibitors of tissue factor or the tissue factor/factor VIIa complex have been developed or identified, and have been tested in experimental studies.
Negative_regulation (inhibitors) of tissue factor
3) Confidence 0.20 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.76 Pain Relevance 0.06
Plasma tissue factor pathway inhibitor and tissue factor antigen levels after administration of heparin in patients with angina pectoris.
Negative_regulation (inhibitor) of tissue factor in Plasma associated with angina
4) Confidence 0.13 Published 1999 Journal Thromb. Res. Section Title Doc Link 10065895 Disease Relevance 0.86 Pain Relevance 0.76
Plasma tissue factor pathway inhibitor and tissue factor antigen levels after administration of heparin in patients with angina pectoris.
Negative_regulation (inhibitor) of tissue factor in Plasma associated with angina
5) Confidence 0.13 Published 1999 Journal Thromb. Res. Section Title Doc Link 10065895 Disease Relevance 0.85 Pain Relevance 0.75
The tissue factor and prothrombin fragment 1+2 levels before administration were elevated in patients with angina pectoris and were reduced to the levels of chest pain syndrome after the administration.
Negative_regulation (reduced) of tissue factor in chest associated with complex regional pain syndromes and angina
6) Confidence 0.05 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10065895 Disease Relevance 0.92 Pain Relevance 0.84
This review analyses the clinical efficacy of the antithrombotic drugs: fractionated heparin, low molecular or fractionated heparins, direct thrombin inhibitors, specific Xa factor inhibitors and inhibitors of the tissue factor pathway in patients with unstable angina and non-Q wave myocardial infarction.
Negative_regulation (inhibitors) of tissue factor associated with angina and myocardial infarction
7) Confidence 0.01 Published 1999 Journal Rev Esp Cardiol Section Abstract Doc Link 10364817 Disease Relevance 0.52 Pain Relevance 0.21
In the future, several improvements in anti-thrombotic therapy are expected: antithrombins, platelet glycoprotein IIb/IIIa receptor blockers and tissue factor inhibitors are all potentially more potent than presently available drugs.
Negative_regulation (inhibitors) of tissue factor in platelet
8) Confidence 0.01 Published 1998 Journal Cas. Lek. Cesk. Section Abstract Doc Link 9818470 Disease Relevance 0.90 Pain Relevance 0.16
Tissue factor, tissue factor pathway inhibitor and cytoadhesive molecules in patients with an acute coronary syndrome.
Negative_regulation (inhibitor) of Tissue factor associated with acute coronary syndrome
9) Confidence 0.01 Published 2003 Journal Physiol Res Section Title Doc Link 14640893 Disease Relevance 1.03 Pain Relevance 0.43
In conclusion, the tissue factor and the tissue factor pathway inhibitor play a crucial role in the initiation of arterial thrombosis.
Negative_regulation (inhibitor) of tissue factor associated with thrombosis
10) Confidence 0.01 Published 2003 Journal Physiol Res Section Abstract Doc Link 14640893 Disease Relevance 0.95 Pain Relevance 0.42
Tissue factor, a measure of endothelial perturbation, was measured as expression on monocytes and platelets, as numbers of tissue factor expressing MP, and as plasma protein [see Supplemental Material, Table 4 (doi:10.1289/ehp.1002237)].
Negative_regulation (numbers) of tissue factor in platelets
11) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0 Pain Relevance 0
The plasma tissue factor increased immediately after UFP exposure and then decreased.
Negative_regulation (decreased) of tissue factor in plasma
12) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0 Pain Relevance 0
Tissue factor, a measure of endothelial perturbation, was measured as expression on monocytes and platelets, as numbers of tissue factor expressing MP, and as plasma protein [see Supplemental Material, Table 4 (doi:10.1289/ehp.1002237)].
Negative_regulation (numbers) of tissue factor in monocytes
13) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0 Pain Relevance 0

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