INT78498

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Context Info
Confidence 0.32
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 7.69
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 9
blood 2
leukocytes 2
neutrophil 2
smooth muscle cells 1
tf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 99.48 Very High Very High Very High
cytokine 18 98.80 Very High Very High Very High
Angina 20 97.92 Very High Very High Very High
Inflammatory response 2 93.68 High High
Nerve growth factor 50 93.52 High High
agonist 36 81.08 Quite High
Inflammatory mediators 2 75.00 Quite High
withdrawal 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 100.00 Very High Very High Very High
Cancer 128 99.92 Very High Very High Very High
INFLAMMATION 24 99.48 Very High Very High Very High
Acute Coronary Syndrome 16 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 10 98.60 Very High Very High Very High
Cv General 3 Under Development 20 97.92 Very High Very High Very High
Necrosis 6 97.76 Very High Very High Very High
Thrombosis 12 97.64 Very High Very High Very High
Sepsis 14 96.20 Very High Very High Very High
Melanoma 102 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then we compared the fold changes of each TF expression between the treated group and the control group (Fig. 5E).
Regulation (changes) of Gene_expression (expression) of TF
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.09 Pain Relevance 0.09
We therefore added EHEC virulence factors to normal whole blood with and without application of shear stress under flow, in order to study their effect on microparticle generation and TF expression.
Regulation (effect) of Gene_expression (expression) of TF in blood associated with stress
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.67 Pain Relevance 0
The relative fold changes of TF expression such as Egr1 and Nr1d1 are different between mRNA levels and protein levels, which may reflect translational modification or proteasomal degradation [25].
Regulation (changes) of Gene_expression (expression) of TF
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.82 Pain Relevance 0.07
Co-stimulation with Stx2 and LPS resulted in an additive effect with regard to platelet-monocyte aggregate formation and TF expression on these aggregates, particularly when high shear forces were applied.
Regulation (effect) of Gene_expression (expression) of TF in monocyte
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.46 Pain Relevance 0
Previous in vitro studies have shown that LPS can induce leukocyte-platelet aggregate formation and TF expression on leukocytes [48], [49] as well as endothelial cells [50].
Regulation (leukocyte) of Gene_expression (expression) of TF in leukocytes
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.79 Pain Relevance 0
Regulation of TF expression in monocytes is controlled by the transcription factors NF-kappaB and AP-1.
Regulation (Regulation) of Gene_expression (expression) of TF in monocytes
6) Confidence 0.13 Published 1998 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 9819023 Disease Relevance 0.78 Pain Relevance 0.15
The effect of shear-stress on platelet-neutrophil aggregates expressing TF was minimal (Figure 6D).
Regulation (effect) of Gene_expression (expressing) of TF in neutrophil associated with stress
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.23 Pain Relevance 0.10
At the surface of viable cells, the transmembrane phospholipid distribution and its regulation may be important for the expression of the catalytic activity of the complex of TF and activated factor VII.
Regulation (important) of Gene_expression (expression) of TF
8) Confidence 0.09 Published 1998 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 9819023 Disease Relevance 0.53 Pain Relevance 0.10
In the present study, we tested the hypothesis that ADMA contribute to TF expression of peripheral monocytes in ACS.
Regulation (contribute) of Gene_expression (expression) of TF in monocytes associated with acute coronary syndrome
9) Confidence 0.09 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 19167713 Disease Relevance 0.98 Pain Relevance 0.52
The experiments using nuclear factor-kappaB (NF-kappaB) inhibitor and transient transfection with wild-type and mutated TF promotor constructs showed that the NF-kappaB is an important transcriptional regulator of ADMA-induced TF expression.
Regulation (regulator) of Gene_expression (expression) of TF
10) Confidence 0.06 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 19167713 Disease Relevance 0.73 Pain Relevance 0.42
It is becoming apparent that the expression of TF on endothelial cells, underlying smooth muscle cells and monocytes is regulated, in part, by proinflammatory cytokines including tumor necrosis factor and IL-1.
Regulation (regulated) of Gene_expression (expression) of TF in monocytes associated with necrosis, cancer and cytokine
11) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861775 Disease Relevance 0.81 Pain Relevance 0.18
It is becoming apparent that the expression of TF on endothelial cells, underlying smooth muscle cells and monocytes is regulated, in part, by proinflammatory cytokines including tumor necrosis factor and IL-1.
Regulation (regulated) of in smooth muscle cells Gene_expression (expression) of TF in monocytes associated with necrosis, cancer and cytokine
12) Confidence 0.01 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861775 Disease Relevance 0.81 Pain Relevance 0.18

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