INT78499

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.64
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 2
monocyte 1
blood cell 1
tf (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 46 89.36 High High
Inflammation 63 82.92 Quite High
Crohn's disease 5 73.44 Quite High
antagonist 1 71.96 Quite High
Pain 3 66.88 Quite High
Angina 6 64.00 Quite High
Inflammatory stimuli 3 59.64 Quite High
substance P 3 51.92 Quite High
isoflurane 1 48.64 Quite Low
Inflammatory response 7 34.00 Quite Low
Disease Link Frequency Relevance Heat
Peptic Ulcer 8 96.52 Very High Very High Very High
Ulcers 21 88.56 High High
INFLAMMATION 75 82.92 Quite High
Stress 40 82.80 Quite High
Sepsis 16 78.88 Quite High
Endotoxemia 20 78.24 Quite High
Systemic Lupus Erythematosus 5 77.20 Quite High
Hypersensitivity 5 75.52 Quite High
Increased Venous Pressure Under Development 15 74.80 Quite High
Disease 35 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our results clearly demonstrated that TF could account for almost the entire healing activity of BT.
TF Binding (account) of
1) Confidence 0.22 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.19 Pain Relevance 0
TF bound to monocytes and neutrophils in complex with platelets to a greater extent than to platelet-free leukocytes.
TF Binding (bound) of in platelet
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
In the platelet-bound leukocyte population (gate two) the FL1 versus FL2 cytograms were used to estimate the percentage of platelet-leukocyte aggregates with bound TF or Stx2 (Figure 1C).
TF Binding (bound) of in platelet
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.08 Pain Relevance 0
Determination of surface-bound TF or Stx on platelet-leukocyte aggregates was performed using a three-color analysis procedure for simultaneous detection of platelet-leukocyte aggregates and TF or Stx2 presence on blood cell aggregates.
TF Binding (bound) of in blood cell
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
TF is a transmembrane cell surface glycoprotein that acts as a receptor for coagulation factor VII/VIIa, catalyzes the conversion of factor X to the active form Xa and ultimately leads to thrombin formation.
TF Binding (leads) of
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 1.17 Pain Relevance 0.16
Stx2, O157LPS or O111:B4LPS or Stx2/LPS increased the number of platelet-monocyte aggregates with surface-bound TF at both low and high shear rates (Figure 6C).
TF Binding (bound) of in monocyte
6) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.20 Pain Relevance 0.04
Finally, an antibody recognizing this TF was used for CHIP/Q-PCR assay and revealed up-regulation of downstream genes.


TF Binding (recognizing) of
7) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.50 Pain Relevance 0.25
At the surface of viable cells, the transmembrane phospholipid distribution and its regulation may be important for the expression of the catalytic activity of the complex of TF and activated factor VII.
TF Binding (complex) of
8) Confidence 0.07 Published 1998 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 9819023 Disease Relevance 0.51 Pain Relevance 0.10

General Comments

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