INT78514

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Context Info
Confidence 0.64
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.48
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cast) nucleus (Cast) cell cycle (Cast)
cytoplasm (Cast)
Anatomy Link Frequency
optic 3
Cast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 18 99.84 Very High Very High Very High
Neuritis 29 98.52 Very High Very High Very High
Glutamate 288 98.06 Very High Very High Very High
Demyelination 3 96.96 Very High Very High Very High
Inflammation 5 95.68 Very High Very High Very High
nMDA receptor 12 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
excitatory amino acid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Optic Neuritis 27 98.52 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 3 98.00 Very High Very High Very High
Demyelinating Disease 9 96.96 Very High Very High Very High
Multiple Sclerosis 3 96.36 Very High Very High Very High
INFLAMMATION 7 95.68 Very High Very High Very High
Death 160 86.44 High High
Apoptosis 194 86.00 High High
Toxicity 12 75.00 Quite High
Neurodegenerative Disease 22 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Translational expression of calpastatin isoforms (80, 68 and 55 KD) was not significantly different in rats with experimental optic neuritis compared to controls.
Gene_expression (expression) of calpastatin in optic associated with optic neuritis and neuritis
1) Confidence 0.64 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 0.96 Pain Relevance 0.78
RT-PCR studies demonstrated no significant change in millicalpain, microcalpain, or calpastatin expression at the mRNA level in optic nerves from animals with experimental optic neuritis compared to controls.
Gene_expression (expression) of calpastatin in optic associated with optic neuritis and neuritis
2) Confidence 0.64 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 1.00 Pain Relevance 0.68
To examine the putative role of calpain in myelinolysis, the activity and expression (translational and transcriptional) of this enzyme and endogenous inhibitor, calpastatin were examined in optic nerves of Lewis rats with experimental allergic encephalomyelitis (EAE), an animal model of optic neuritis.
Gene_expression (expression) of calpastatin in optic associated with multiple sclerosis, optic neuritis, neuritis and experimental autoimmune encephalomyelitis
3) Confidence 0.56 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 0.86 Pain Relevance 0.48
None of the NSAIDs affected expression of calpastatin mRNA or protein.
Gene_expression (expression) of calpastatin mRNA associated with cinod
4) Confidence 0.38 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18281595 Disease Relevance 0.26 Pain Relevance 0.56
Accordingly, quantitative real-time reverse transcription polymerase chain reaction and immunoblotting were performed to assess the effects of NSAIDs on the expression of mRNA and protein for calpain 8, calpain 2, calpain 1, and calpastatin.
Gene_expression (expression) of calpastatin associated with cinod
5) Confidence 0.29 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18281595 Disease Relevance 0.35 Pain Relevance 0.70
Treatment with glutamate induced accumulation of both 145 KDa and 120 KDa BDPs in primary cortical cells, which could be reduced with both calpain inhibitor (ALLN) and caspase-3 inhibitor (z-DEVD-fmk).
Gene_expression (reduced) of calpain inhibitor associated with glutamate
6) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.86 Pain Relevance 0.26
The presence of calpain inhibitor 25 ?
Gene_expression (presence) of calpain inhibitor
7) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.19 Pain Relevance 0.23

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