INT78515

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 9.40
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
optic 3
liver 1
nerve 1
phrenic 1
Mag (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 20 99.82 Very High Very High Very High
intrathecal 4 98.96 Very High Very High Very High
peripheral neuropathy 1 98.96 Very High Very High Very High
Neuritis 24 98.72 Very High Very High Very High
anesthesia 2 97.60 Very High Very High Very High
Sciatic nerve 4 94.08 High High
Inflammation 26 93.72 High High
Demyelination 12 93.64 High High
allodynia 4 92.52 High High
Hyperalgesia 4 91.96 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 24 99.82 Very High Very High Very High
Nervous System Injury 8 99.82 Very High Very High Very High
Adhesions 4 99.08 Very High Very High Very High
Peripheral Neuropathy 1 98.96 Very High Very High Very High
Optic Neuritis 24 98.72 Very High Very High Very High
Hyperplasia 1 98.20 Very High Very High Very High
Pancreatic Cancer 4 95.40 Very High Very High Very High
Thrombophilia 1 94.52 High High
INFLAMMATION 29 93.72 High High
Demyelinating Disease 16 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, myelin associated glycoprotein (MAG) levels were decreased by 25.5% while calpain translational expression and calpain-autolyzed fodrin levels were increased by 72.1% and 462.8% respectively, in experimental optic neuritis compared to controls.
Negative_regulation (decreased) of myelin associated glycoprotein in optic associated with optic neuritis and neuritis
1) Confidence 0.54 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 1.00 Pain Relevance 0.76
However, myelin associated glycoprotein (MAG) levels were decreased by 25.5% while calpain translational expression and calpain-autolyzed fodrin levels were increased by 72.1% and 462.8% respectively, in experimental optic neuritis compared to controls.
Negative_regulation (decreased) of MAG in optic associated with optic neuritis and neuritis
2) Confidence 0.54 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 0.99 Pain Relevance 0.76
Conversely, specific inhibition of MAG or sialyl-T MUC1 partially blocked adhesion.
Negative_regulation (inhibition) of MAG associated with adhesions
3) Confidence 0.32 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.88 Pain Relevance 0.06
In the present study, we found that a single intrathecal injection of LPA evoked a dose- and time-dependent down-regulation of myelin-associated glycoprotein (MAG) in the DR through LPA(1) receptor.
Negative_regulation (down-regulation) of myelin-associated glycoprotein associated with intrathecal
4) Confidence 0.23 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20420580 Disease Relevance 0.67 Pain Relevance 0.54
In the present study, we found that a single intrathecal injection of LPA evoked a dose- and time-dependent down-regulation of myelin-associated glycoprotein (MAG) in the DR through LPA(1) receptor.
Negative_regulation (down-regulation) of MAG associated with intrathecal
5) Confidence 0.23 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20420580 Disease Relevance 0.67 Pain Relevance 0.54
The E-64d treatments significantly blocked nerve injury-induced MAG down-regulation and neuropathic pain.
Negative_regulation (down-regulation) of MAG in nerve associated with nervous system injury and neuropathic pain
6) Confidence 0.20 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20420580 Disease Relevance 1.01 Pain Relevance 0.78
The present study provides strong evidence that LPA-induced calpain activation plays a crucial role in the manifestation of neuropathic pain through MAG down-regulation in the DR.
Negative_regulation (down-regulation) of MAG associated with neuropathic pain
7) Confidence 0.20 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20420580 Disease Relevance 0.89 Pain Relevance 0.63
Results showed myelin associated glycoprotein and 68 kD neurofilament protein levels were significantly decreased while calpain translational expression and calpain-autolyzed fodrin levels were significantly increased in experimental optic neuritis compared to controls.
Negative_regulation (decreased) of myelin associated glycoprotein in optic associated with optic neuritis and neuritis
8) Confidence 0.13 Published 1999 Journal Histol. Histopathol. Section Abstract Doc Link 10212825 Disease Relevance 0.57 Pain Relevance 0.61
Propofol abolished the phrenic long-term facilitation in rats.
Negative_regulation (abolished) of phrenic long-term facilitation in phrenic
9) Confidence 0.06 Published 2010 Journal Respir Physiol Neurobiol Section Title Doc Link 20038457 Disease Relevance 0.60 Pain Relevance 0.19
Associated findings include pseudoxanthum elasticum in 2 patients [44,45], peripheral neuropathy with the presence of monoclonal IgM with anti-MAG (myelin-associated glycoprotein) in 1 patient [46], C4 deficiency in 2 patients [42] and nodular regenerative hyperplasia of the liver in 1 patient [47], impairment of renal function in 1 patient [48], thrombophilia with anti-phospholipid antibodies and hyperhomocysteinemia [49] and hearing loss [3].
Negative_regulation (deficiency) of myelin-associated glycoprotein in liver associated with deafness, thrombophilia, peripheral neuropathy, hyperhomocysteinemia and hyperplasia
10) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018454 Disease Relevance 2.10 Pain Relevance 0.18

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