INT78516

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.56
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
optic 2
nerve 1
Mag (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 5 99.16 Very High Very High Very High
Neuritis 18 98.72 Very High Very High Very High
depression 6 98.64 Very High Very High Very High
Sciatic nerve 1 94.40 High High
long-term potentiation 9 93.32 High High
allodynia 1 92.84 High High
Hyperalgesia 1 92.28 High High
antagonist 1 88.00 High High
anesthesia 1 86.36 High High
halothane 1 85.92 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 99.98 Very High Very High Very High
Neuropathic Pain 6 99.16 Very High Very High Very High
Optic Neuritis 18 98.72 Very High Very High Very High
Depression 6 98.64 Very High Very High Very High
Hyperalgesia 2 92.28 High High
INFLAMMATION 3 83.84 Quite High
Multiple Sclerosis 2 80.92 Quite High
Experimental Autoimmune Encephalomyelitis 2 80.72 Quite High
Demyelinating Disease 8 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, myelin associated glycoprotein (MAG) levels were decreased by 25.5% while calpain translational expression and calpain-autolyzed fodrin levels were increased by 72.1% and 462.8% respectively, in experimental optic neuritis compared to controls.
Positive_regulation (increased) of MAG in optic associated with optic neuritis and neuritis
1) Confidence 0.43 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 1.01 Pain Relevance 0.79
However, myelin associated glycoprotein (MAG) levels were decreased by 25.5% while calpain translational expression and calpain-autolyzed fodrin levels were increased by 72.1% and 462.8% respectively, in experimental optic neuritis compared to controls.
Positive_regulation (increased) of myelin associated glycoprotein in optic associated with optic neuritis and neuritis
2) Confidence 0.43 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 1.02 Pain Relevance 0.79
The E-64d treatments significantly blocked nerve injury-induced MAG down-regulation and neuropathic pain.
Positive_regulation (induced) of MAG in nerve associated with nervous system injury and neuropathic pain
3) Confidence 0.24 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20420580 Disease Relevance 1.01 Pain Relevance 0.78
Long-term depression (LTD) alone (magnitude of 84%) was induced in 40% of the animals, while short-term potentiation (STP) alone (magnitude of 123%) was induced in 10%.
Positive_regulation (induced) of short-term potentiation associated with depression
4) Confidence 0.02 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14645375 Disease Relevance 0.51 Pain Relevance 0.77

General Comments

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