INT78517

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Context Info
Confidence 0.30
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cast) nucleus (Cast) cell cycle (Cast)
cytoplasm (Cast)
Anatomy Link Frequency
optic 2
Cast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 9 99.98 Very High Very High Very High
Neuritis 9 98.20 Very High Very High Very High
Demyelination 1 77.16 Quite High
Inflammation 2 75.88 Quite High
Disease Link Frequency Relevance Heat
Optic Neuritis 9 98.20 Very High Very High Very High
Multiple Sclerosis 1 87.92 High High
Experimental Autoimmune Encephalomyelitis 1 87.72 High High
Demyelinating Disease 3 77.16 Quite High
INFLAMMATION 3 75.88 Quite High
Toxicity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the NSAIDs affected expression of calpastatin mRNA or protein.
Regulation (affected) of Gene_expression (expression) of calpastatin mRNA associated with cinod
1) Confidence 0.30 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18281595 Disease Relevance 0.26 Pain Relevance 0.56
RT-PCR studies demonstrated no significant change in millicalpain, microcalpain, or calpastatin expression at the mRNA level in optic nerves from animals with experimental optic neuritis compared to controls.
Neg (no) Regulation (change) of Gene_expression (expression) of calpastatin in optic associated with optic neuritis and neuritis
2) Confidence 0.22 Published 1998 Journal Exp. Eye Res. Section Abstract Doc Link 9820787 Disease Relevance 1.01 Pain Relevance 0.69

General Comments

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