INT7852

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 2.02
Pain Relevance 12.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
medulla 4
pancreas 4
ventricle 2
brain 2
ventral 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 120 100.00 Very High Very High Very High
Somatostatin 9 100.00 Very High Very High Very High
Intracerebroventricular 6 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Hippocampus 3 99.68 Very High Very High Very High
Analgesic 16 99.50 Very High Very High Very High
Morphine 32 99.44 Very High Very High Very High
Substantia nigra 2 99.36 Very High Very High Very High
opiate 8 99.00 Very High Very High Very High
electroacupuncture 14 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 4 99.70 Very High Very High Very High
Sprains And Strains 5 98.54 Very High Very High Very High
Urological Neuroanatomy 24 96.72 Very High Very High Very High
Ganglion Cysts 1 95.32 Very High Very High Very High
Increased Venous Pressure Under Development 4 79.68 Quite High
Pressure Volume 2 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we hypothesized that the P77PMC animals would show an enhanced analgesic response based on their decreased CCK levels producing a diminished endogenous opiate antagonism.
Negative_regulation (decreased) of Gene_expression (producing) of CCK associated with analgesic, opiate and cholecystokinin
1) Confidence 0.59 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037405 Disease Relevance 0.29 Pain Relevance 1.31
The results argue that blocking the CCK gene expression in the brain may tilt the balance between opioid and anti-opioid peptides in favor of the former, thus strengthening the EA analgesia and morphine analgesia, and delaying the development of opioid tolerance.
Negative_regulation (blocking) of Gene_expression (expression) of CCK gene in brain associated with tolerance, electroacupuncture, opioid, morphine and analgesia
2) Confidence 0.59 Published 1997 Journal Pain Section Abstract Doc Link 9200176 Disease Relevance 0.22 Pain Relevance 1.99
OLETF rats are confirmed as a new experimental model deficient in CCK-A receptor gene expression and represent a useful tool for studying the physiological role of these in vivo.
Negative_regulation (deficient) of Gene_expression (expression) of CCK associated with cholecystokinin
3) Confidence 0.59 Published 1996 Journal Pancreas Section Abstract Doc Link 8830334 Disease Relevance 0.06 Pain Relevance 0.45
In order to block the expression of the gene encoding preproCCK in the brain, antisense CCK expression vector pSV2-CCKAS was microinjected into the lateral cerebral ventricle of the rat, leading to a decrease of the CCK-mRNA as well as the CCK-8 content in rat brain.
Negative_regulation (block) of Gene_expression (expression) of preproCCK in ventricle
4) Confidence 0.51 Published 1997 Journal Pain Section Abstract Doc Link 9200176 Disease Relevance 0.36 Pain Relevance 1.49
Using the P77PMC strain of rat, which is genetically prone to audiogenic seizures, and also has decreased levels of cholecystokinin (CCK), we examined the analgesic response to peripheral electrical stimulation, which is, in part, opiate-mediated.
Negative_regulation (decreased) of Gene_expression (levels) of cholecystokinin associated with epilepsy, analgesic, opiate, sprains and strains and cholecystokinin
5) Confidence 0.43 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037405 Disease Relevance 0.20 Pain Relevance 0.88
In one subject, cholecystokinin (CCK) alone (10-32 micrograms/kg) produced dose-dependent decreases in rate in the first component, while in the other two subjects relatively little decrease in rate occurred.
Negative_regulation (decreases) of Gene_expression (produced) of CCK associated with cholecystokinin
6) Confidence 0.43 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3211965 Disease Relevance 0 Pain Relevance 0.72
In one subject, cholecystokinin (CCK) alone (10-32 micrograms/kg) produced dose-dependent decreases in rate in the first component, while in the other two subjects relatively little decrease in rate occurred.
Negative_regulation (decreases) of Gene_expression (produced) of cholecystokinin associated with cholecystokinin
7) Confidence 0.43 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3211965 Disease Relevance 0 Pain Relevance 0.72
Unilateral rhizotomy, but not cervical hemisection produced a significant but incomplete depletion of CCK and VIP immunoreactivity in dorsal, but not ventral horn.
Negative_regulation (depletion) of Gene_expression (produced) of CCK in ventral associated with cholecystokinin
8) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.10 Pain Relevance 0.63
Otsuka Long-Evans Tokushima Fatty (OLETF) rats revealed no or reduced expression of the cholecystokinin (CCK)-A receptor gene in the pancreas and that the pancreas of this strain of rats did not respond to CCK stimulation.
Negative_regulation (reduced) of Gene_expression (expression) of cholecystokinin in pancreas associated with sprains and strains and cholecystokinin
9) Confidence 0.43 Published 1996 Journal Pancreas Section Abstract Doc Link 8830334 Disease Relevance 0.10 Pain Relevance 0.29
We observed in these regions that cholecystokinin and tyrosine hydroxylase mRNAs coexisted in the same neurons but not all dopamine cells expressed cholecystokinin mRNA. 6-Hydroxydopamine-induced destruction of mesostriatal dopaminergic neurons resulted in a complete loss of cholecystokinin and tyrosine hydroxylase mRNA expression throughout the substantia nigra pars compacta, indicating that all cholecystokinin expressing cells are 6-hydroxydopamine-sensitive.
Negative_regulation (loss) of Gene_expression (expression) of cholecystokinin in dopaminergic neurons associated with dopamine, substantia nigra and cholecystokinin
10) Confidence 0.42 Published 1989 Journal Neuroscience Section Abstract Doc Link 2566954 Disease Relevance 0 Pain Relevance 0.69
Immunoneutralization of endogenous somatostatin by administration of somatostatin monoclonal antibody abolished the inhibition produced by CCK.
Negative_regulation (inhibition) of Gene_expression (produced) of CCK associated with somatostatin and cholecystokinin
11) Confidence 0.42 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1357976 Disease Relevance 0 Pain Relevance 0.95
Systemic administration of the gastrointestinal hormone cholecystokinin (CCK) selectively inhibits splanchnic sympathetic vasomotor discharge and differentially affects presympathetic vasomotor neurons of the rostroventrolateral medulla (RVLM).
Negative_regulation (inhibits) of Gene_expression (administration) of gastrointestinal hormone cholecystokinin in medulla associated with medulla and cholecystokinin
12) Confidence 0.41 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12975810 Disease Relevance 0.30 Pain Relevance 0.38
Systemic administration of the gastrointestinal hormone cholecystokinin (CCK) selectively inhibits splanchnic sympathetic vasomotor discharge and differentially affects presympathetic vasomotor neurons of the rostroventrolateral medulla (RVLM).
Negative_regulation (inhibits) of Gene_expression (administration) of CCK in medulla associated with medulla and cholecystokinin
13) Confidence 0.41 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12975810 Disease Relevance 0.30 Pain Relevance 0.38
Otsuka Long-Evans Tokushima Fatty (OLETF) rats revealed no or reduced expression of the cholecystokinin (CCK)-A receptor gene in the pancreas and that the pancreas of this strain of rats did not respond to CCK stimulation.
Negative_regulation (reduced) of Gene_expression (expression) of CCK in pancreas associated with sprains and strains and cholecystokinin
14) Confidence 0.38 Published 1996 Journal Pancreas Section Abstract Doc Link 8830334 Disease Relevance 0.10 Pain Relevance 0.29
The analgesic action of beta-endorphin, as observed in the hot plate test with rats, was effectively suppressed by intracerebroventricular (i.c.v.) injection of caerulein and cholecystokinin octapeptide (CCK-8).
Negative_regulation (suppressed) of Gene_expression (injection) of cholecystokinin associated with analgesic, cholecystokinin and intracerebroventricular
15) Confidence 0.32 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6286327 Disease Relevance 0 Pain Relevance 0.48
There was also an age-related decrease for somatostatin and substance P contents in the striatum and the hypothalamus in the day, and in cholecystokinin levels in the hippocampus, and the hypothalamus at night.
Negative_regulation (decrease) of in striatum Gene_expression (levels) of cholecystokinin in hippocampus associated with somatostatin, hippocampus, cholecystokinin and substance p
16) Confidence 0.23 Published 1993 Journal Neurobiol. Aging Section Abstract Doc Link 8295655 Disease Relevance 0 Pain Relevance 1.21

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