INT78524

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 8.90
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) plasma membrane (Neu1) lysosome (Neu1)
Anatomy Link Frequency
mammary gland 1
pancreas 1
Neu1 (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 324 99.84 Very High Very High Very High
rheumatoid arthritis 384 98.88 Very High Very High Very High
spinal inflammation 220 98.60 Very High Very High Very High
methotrexate 36 97.32 Very High Very High Very High
peptic ulcer disease 1 90.04 High High
cytokine 18 87.44 High High
cINOD 19 76.84 Quite High
Crohn's disease 16 71.76 Quite High
Chronic pancreatitis 1 67.20 Quite High
Etanercept 4 57.16 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 5 99.40 Very High Very High Very High
Pancreatic Cancer 6 98.92 Very High Very High Very High
Rheumatoid Arthritis 384 98.88 Very High Very High Very High
Low Back Pain 220 98.60 Very High Very High Very High
Cancer 85 98.44 Very High Very High Very High
Breast Cancer 50 98.24 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 9 98.20 Very High Very High Very High
Thrombosis 8 97.88 Very High Very High Very High
Thrombocytopenia 12 97.32 Very High Very High Very High
Sprains And Strains 4 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of ANA and aPL autoantibodies was clearly due to infliximab, especially in the RA group, because no such induction was observed in the control RA group treated with methotrexate alone.
Positive_regulation (induction) of aPL associated with infliximab, rheumatoid arthritis and methotrexate
1) Confidence 0.67 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.90 Pain Relevance 0.64
Our results confirmed the occurrence of ANA and anti-dsDNA autoantibodies and demonstrated that the induction of ANA, anti-dsDNA and aPL autoantibodies is related to infliximab treatment in both RA and AS, with no significant relationship to clinical manifestations.



Positive_regulation (induction) of aPL associated with spinal inflammation, infliximab and rheumatoid arthritis
2) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064868 Disease Relevance 1.24 Pain Relevance 1.05
ANA, anti-dsDNA and aPL were the only autoantibodies to be significantly induced by infliximab treatment in RA and AS patients.
Positive_regulation (induced) of aPL associated with spinal inflammation, infliximab and rheumatoid arthritis
3) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.42 Pain Relevance 1.26
Isotypes of induced anti-dsDNA, aPL/ACL and anti-?
Positive_regulation (induced) of aPL
4) Confidence 0.21 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.70 Pain Relevance 0.98
MMTV/NDL mice express a mutationally activated HER2/neu transgene that drives formation of multiple DCIS-like tumors in each mammary gland.
Positive_regulation (activated) of neu in mammary gland associated with cancer and noninfiltrating intraductal carcinoma
5) Confidence 0.13 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.70 Pain Relevance 0.28
Among the findings: peptic ulcer disease is a significant predisposing risk factor (odds ratio = 3.9) for pancreatic cancer; as many as 50% of all intraductal papillary mucinous neoplasms are associated with invasive adenocarcinomas; alteration of gene expression via methylation of a gene promotor region constitutes a potentially reversible method of tumor suppressor gene inactivation; > 400 transcriptional alterations of gene expression have been identified for pancreatic cancer; some common molecular markers such as p53 and HER-2/neu may be related to morphologic alterations of in situ neoplasia and to transcriptional alterations of gene expression rather than mutational events; epidermal growth factor (EGF), transforming growth factor beta (TGF-beta), and related molecules may modulate gene transcription via "autocrine" or "paracrine" mechanisms; several cytokines, amylin (islet amyloid polypeptide), and other cachexia factors are responsible for paraneoplastic peripheral insulin resistance, ineffective utilization of glucose, and profound cachexia.
Spec (may) Positive_regulation (related) of neu associated with peptic ulcer disease, alzheimer's dementia, insulin resistance, disease, cytokine, adenocarcinoma, appetite loss, cancer and pancreatic cancer
6) Confidence 0.05 Published 1998 Journal Pancreas Section Abstract Doc Link 9821173 Disease Relevance 1.16 Pain Relevance 0.13
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Positive_regulation (evaluation) of neu in pancreas associated with hyperplasia
7) Confidence 0.01 Published 1999 Journal Hum. Pathol. Section Title Doc Link 10029438 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

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