INT78525

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.49
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RAD21) nuclear chromosome (RAD21) chromosome segregation (RAD21)
nucleolus (RAD21) nucleus (RAD21) cell division (RAD21)
RAD21 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 96.86 Very High Very High Very High
Pain 1 96.32 Very High Very High Very High
imagery 1 88.04 High High
positron emission tomography 1 84.50 Quite High
cytokine 1 42.40 Quite Low
peptic ulcer disease 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 5 100.00 Very High Very High Very High
Adenocarcinoma 3 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 1 100.00 Very High Very High Very High
Cancer 11 99.98 Very High Very High Very High
Pain 1 96.32 Very High Very High Very High
Islet Cell Adenoma 1 82.08 Quite High
Hyperplasia 1 79.06 Quite High
Appetite Loss 2 49.92 Quite Low
Insulin Resistance 1 47.56 Quite Low
Alzheimer's Dementia 1 43.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the clinical diagnostic arena: the World Health Organization established a standard nomenclature for intraductal papillary mucinous neoplasms, mucinous cystic tumors, intraductal mucinous hyperplasias, and solid pseudopapillary tumors; focal glandular differentiation may be commonly identified within pancreatic endocrine neoplasms (islet cell tumors) while not necessarily implying an unfavorable prognosis typical of ductal adenocarcinomas; positron emission tomography scanning may be used for evaluation of early tumor response to novel chemotherapeutic regimens; helical computed tomography (CT) is the state of the art in preoperative imaging for pancreatic cancer; neoadjuvant 5-fluorouracil (5-FU)-based chemoradiation in 39 "resectable" patients provided a median survival of 19 months, actuarial 4-year survival of 19%, and improved local tumor control; gemcitabine has shown promise in alleviating tumor-related symptoms with a significantly better "clinical benefit response" than single agent 5-FU (23.8 vs. 4.8%, p = 0.0022) based on change in pain intensity, daily analgesic consumption, performance status, and weight; a significant survival advantage was demonstrated in patients treated with conventional therapies whose tumors expressed p21WAF-1, an important inhibitor of cell cycle progression and downstream molecule of p53 and TGF-beta; a p21-adenovirus (rAD-p21) gene therapy resulted in significant growth inhibition of pancreatic cancer cell lines in tissue culture, and development of a successful SCID mouse-human pancreatic adenocarcinoma xenograft model provided an animal model for preclinical trials of rAD-p21.
Gene_expression (expressed) of rAD-p21 associated with pain, islet cell adenoma, analgesic, severe combined immunodeficiency, hyperplasia, adenocarcinoma, cancer, pancreatic cancer, positron emission tomography and imagery
1) Confidence 0.03 Published 1998 Journal Pancreas Section Abstract Doc Link 9821173 Disease Relevance 1.49 Pain Relevance 0.28

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