INT78556

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.93
Pain Relevance 10.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC)
Anatomy Link Frequency
cerebrospinal fluid 2
trigeminal ganglia 2
RAIC 1
plasma 1
brain 1
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 112 100.00 Very High Very High Very High
Pain 15 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Hippocampus 6 99.68 Very High Very High Very High
Enkephalin 3 99.64 Very High Very High Very High
substance P 16 99.32 Very High Very High Very High
agonist 5 99.32 Very High Very High Very High
Neuropeptide 13 99.18 Very High Very High Very High
Calcitonin gene-related peptide 20 99.16 Very High Very High Very High
amygdala 12 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.04 Very High Very High Very High
Pain 13 98.76 Very High Very High Very High
Low Back Pain 1 93.60 High High
Urological Neuroanatomy 14 89.52 High High
Ganglion Cysts 12 89.48 High High
Nociception 1 88.28 High High
Cognitive Disorder 3 83.20 Quite High
Recurrence 6 77.04 Quite High
Bordatella Infection 1 50.48 Quite High
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin was predominantly (78%) expressed in medium-sized cells (30-60 microm).
Gene_expression (expressed) of Nociceptin associated with orphanin
1) Confidence 0.76 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576178 Disease Relevance 0.24 Pain Relevance 1.04
In conclusion, nociceptin is expressed in human trigeminal ganglia but not in cerebral blood vessels.
Neg (not) Gene_expression (expressed) of nociceptin in blood vessels associated with orphanin
2) Confidence 0.76 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576178 Disease Relevance 0.14 Pain Relevance 0.98
Nociceptin receptor mRNA is expressed in human trigeminal ganglia but not in basilar arteries.
Neg (not) Gene_expression (expressed) of Nociceptin in trigeminal ganglia associated with orphanin
3) Confidence 0.66 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576178 Disease Relevance 0.14 Pain Relevance 0.90
Reverse transcriptase-polymerase chain reaction detected the expression of nociceptin receptor mRNA in trigeminal ganglia but not in basilar arteries.
Gene_expression (expression) of nociceptin in trigeminal ganglia associated with orphanin
4) Confidence 0.66 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576178 Disease Relevance 0.22 Pain Relevance 1.18
We have measured plasma and cerebrospinal fluid (CSF) concentrations of nociceptin, the endogenous agonist of the orphan opioid receptor-like receptor (ORL-1).
Gene_expression (concentrations) of nociceptin in CSF associated with orphanin, agonist and opioid receptor
5) Confidence 0.59 Published 1998 Journal Pain Section Abstract Doc Link 9822213 Disease Relevance 0.23 Pain Relevance 0.53
Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine.
Gene_expression (levels) of Nociceptin in cerebrospinal fluid associated with lasting pain, orphanin, morphine and intrathecal
6) Confidence 0.58 Published 2006 Journal J Pain Symptom Manage Section Title Doc Link 17000354 Disease Relevance 0.56 Pain Relevance 1.73
To address this hypothesis, we evaluated whether expression of the pronociceptin (PNOC) and OPRL1 genes is altered in human alcoholics. mRNAs transcribed from these genes were analyzed by quantitative RT-PCR in the prefrontal and orbitofrontal cortices, central amygdala and hippocampal dentate gyrus, structures controlling alcohol consumption.
Spec (whether) Gene_expression (expression) of PNOC in prefrontal associated with amygdala and alcohol
7) Confidence 0.58 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.08 Pain Relevance 0.70
We hypothesise that chronic ethanol intake downregulates PNOC and OPRL1 gene expression in the hippocampus and amygdala, respectively.
Gene_expression (expression) of PNOC in amygdala associated with hippocampus and amygdala
8) Confidence 0.50 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.14 Pain Relevance 0.58
To assess the notable stability of multimeric peptides, different bioactive neuropeptides, including enkephalins, neurotensin and nociceptin, were synthesized in monomeric and tetrabranched forms and incubated with human plasma and serum and with rat brain membrane extracts.
Gene_expression (synthesized) of nociceptin in plasma associated with orphanin, neuropeptide and enkephalin
9) Confidence 0.22 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12972419 Disease Relevance 0 Pain Relevance 0.24
We hypothesise that chronic ethanol intake downregulates PNOC and OPRL1 gene expression in the hippocampus and amygdala, respectively.
Gene_expression (expression) of PNOC in hippocampus associated with hippocampus and amygdala
10) Confidence 0.17 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.14 Pain Relevance 0.58
Cloning and bioinformatics of amphibian mu, delta, kappa, and nociceptin opioid receptors expressed in brain tissue: evidence for opioid receptor divergence in mammals.
Gene_expression (expressed) of nociceptin in brain associated with pain, orphanin and opioid receptor
11) Confidence 0.15 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17452077 Disease Relevance 0 Pain Relevance 1.10
Prepronociceptin is highly expressed in the RAIC.
Gene_expression (expressed) of Prepronociceptin in RAIC
12) Confidence 0.14 Published 2010 Journal Neuroscience Section Abstract Doc Link 20359524 Disease Relevance 1.05 Pain Relevance 1.03

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