INT78561

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.65
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)
Anatomy Link Frequency
cartilage 1
basal ganglia 1
Heart 1
Hbegf (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 12 99.24 Very High Very High Very High
Osteoarthritis 10 91.92 High High
midbrain 1 87.84 High High
depression 1 87.80 High High
Pain 1 80.12 Quite High
cytokine 1 75.00 Quite High
Angina 1 75.00 Quite High
Dynorphin 3 62.88 Quite High
substance P 3 61.76 Quite High
Enkephalin 4 48.56 Quite Low
Disease Link Frequency Relevance Heat
Diphtheria 2 100.00 Very High Very High Very High
Basal Ganglia Disease 2 98.40 Very High Very High Very High
Death 1 97.72 Very High Very High Very High
Targeted Disruption 3 97.16 Very High Very High Very High
Parkinson's Disease 1 95.12 Very High Very High Very High
Neurodegenerative Disease 2 94.40 High High
Disease 3 92.96 High High
Osteoarthritis 11 91.92 High High
Depression 1 87.80 High High
Coronary Artery Disease 1 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: The appropriate management of patients with an intermediate Duke treadmill score (DTS) is not well established.The aim of this study is to compare several treadmill indexes (American College of Cardiology/American Heart Association (ACC/AHA) High-Risk Criteria for exercise testing,Veterans Affairs and West Virginia Prognostic Score, ST/Heart Rate Index, Failure to attain 85% of age-predicted maximum Heart Rate) with ST-segment depression in detecting significant or severe coronary artery disease as determined by coronary angiography in patients with an intermediate DTS.
Neg (not) Gene_expression (established.The) of DTS in Heart associated with coronary artery disease and depression
1) Confidence 0.56 Published 2008 Journal Acta Cardiol Section Abstract Doc Link 19013997 Disease Relevance 0.25 Pain Relevance 0.12
Using functional categorization combined with gene ontology and a statistical analysis, five genes were found to be highly expressed in damaged cartilage (HBEGF, ASUS, CRLF1, LOX, CDA), whereas three genes were highly expressed in intact tissues (CHST2, PTPRD, CPAN6).
Gene_expression (expressed) of HBEGF in cartilage
2) Confidence 0.41 Published 2010 Journal Calcif. Tissue Int. Section Abstract Doc Link 19921088 Disease Relevance 0.80 Pain Relevance 0.40
Mice were generated in which an attenuated form of the diphtheria toxin gene (tox-176) was expressed exclusively in D1 dopamine receptor (D1R)-positive cells with the aim of determining the effect of this mutation on development of the basal ganglia and on the locomotor phenotype.
Gene_expression (expressed) of diphtheria toxin gene in basal ganglia associated with dopamine receptor and diphtheria
3) Confidence 0.15 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822743 Disease Relevance 1.01 Pain Relevance 0.24
In this model the expression of an attenuated form of the diphtheria toxin gene was tightly controlled by D1 dopamine receptor regulatory domains.
Gene_expression (expression) of diphtheria toxin gene associated with dopamine receptor and diphtheria
4) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682710 Disease Relevance 0.59 Pain Relevance 0.21

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