INT78561

Context Info Confidence 0.56 First Reported 1998 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.65 Pain Relevance 0.97

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)

Anatomy Link Frequency cartilage 1 basal ganglia 1 Heart 1 Hbegf (Mus musculus)

Pain Link Frequency Relevance Heat dopamine receptor 12 99.24 Osteoarthritis 10 91.92 midbrain 1 87.84 depression 1 87.80 Pain 1 80.12 cytokine 1 75.00 Angina 1 75.00 Dynorphin 3 62.88 substance P 3 61.76 Enkephalin 4 48.56

Disease Link Frequency Relevance Heat Diphtheria 2 100.00 Basal Ganglia Disease 2 98.40 Death 1 97.72 Targeted Disruption 3 97.16 Parkinson's Disease 1 95.12 Neurodegenerative Disease 2 94.40 Disease 3 92.96 Osteoarthritis 11 91.92 Depression 1 87.80 Coronary Artery Disease 1 85.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BACKGROUND: The appropriate management of patients with an intermediate Duke treadmill score (DTS) is not well established.The aim of this study is to compare several treadmill indexes (American College of Cardiology/American Heart Association (ACC/AHA) High-Risk Criteria for exercise testing,Veterans Affairs and West Virginia Prognostic Score, ST/Heart Rate Index, Failure to attain 85% of age-predicted maximum Heart Rate) with ST-segment depression in detecting significant or severe coronary artery disease as determined by coronary angiography in patients with an intermediate DTS.

Neg (not) Gene_expression (established.The) of DTS in Heart associated with coronary artery disease and depression

1) Confidence 0.56 Published 2008 Journal Acta Cardiol Section Abstract Doc Link 19013997 Disease Relevance 0.25 Pain Relevance 0.12

Using functional categorization combined with gene ontology and a statistical analysis, five genes were found to be highly expressed in damaged cartilage (HBEGF, ASUS, CRLF1, LOX, CDA), whereas three genes were highly expressed in intact tissues (CHST2, PTPRD, CPAN6).

Gene_expression (expressed) of HBEGF in cartilage

2) Confidence 0.41 Published 2010 Journal Calcif. Tissue Int. Section Abstract Doc Link 19921088 Disease Relevance 0.80 Pain Relevance 0.40

Mice were generated in which an attenuated form of the diphtheria toxin gene (tox-176) was expressed exclusively in D1 dopamine receptor (D1R)-positive cells with the aim of determining the effect of this mutation on development of the basal ganglia and on the locomotor phenotype.

Gene_expression (expressed) of diphtheria toxin gene in basal ganglia associated with dopamine receptor and diphtheria

3) Confidence 0.15 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822743 Disease Relevance 1.01 Pain Relevance 0.24

In this model the expression of an attenuated form of the diphtheria toxin gene was tightly controlled by D1 dopamine receptor regulatory domains.

Gene_expression (expression) of diphtheria toxin gene associated with dopamine receptor and diphtheria

4) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682710 Disease Relevance 0.59 Pain Relevance 0.21

General Comments

This test has worked.