INT78568

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Context Info
Confidence 0.30
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.78
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Glb1) carbohydrate metabolic process (Glb1) lysosome (Glb1)
Anatomy Link Frequency
ventral 4
Glb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 15 100.00 Very High Very High Very High
Ventral tegmentum 11 100.00 Very High Very High Very High
cocaine 6 99.52 Very High Very High Very High
withdrawal 5 98.72 Very High Very High Very High
addiction 2 98.66 Very High Very High Very High
Locus ceruleus 10 97.68 Very High Very High Very High
opiate 3 94.16 High High
Raphe 1 83.84 Quite High
amygdala 2 75.20 Quite High
Nucleus accumbens 2 74.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 99.12 Very High Very High Very High
Morphine Dependence 1 98.66 Very High Very High Very High
Opiate Addiction 1 94.16 High High
Heart Disease 4 88.44 High High
Frailty 3 80.16 Quite High
Arrhythmias 2 Under Development 8 31.36 Quite Low
Toxicity 10 25.00 Low Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, beta-galactosidase expression in the ventral tegmental area was decreased 20-25% by chronic morphine and unaffected by chronic cocaine administration.
Negative_regulation (decreased) of Gene_expression (expression) of beta-galactosidase in ventral associated with ventral tegmentum, cocaine and morphine
1) Confidence 0.30 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.16 Pain Relevance 0.91
In contrast, beta-galactosidase expression in the ventral tegmental area was decreased 20-25% by chronic morphine and unaffected by chronic cocaine administration.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of beta-galactosidase in ventral associated with ventral tegmentum, cocaine and morphine
2) Confidence 0.22 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.16 Pain Relevance 0.92
To test the pathophysiology of CUG repeat encoding RNAs, we developed and analyzed mice with cardiac-specific expression of a beta-galactosidase cassette in which a (CTG)400 repeat tract was positioned 3?
Negative_regulation (positioned) of Gene_expression (cassette) of beta-galactosidase
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597774 Disease Relevance 0.17 Pain Relevance 0
To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal.
Negative_regulation (mapping) of Gene_expression (expression) of beta-galactosidase associated with targeted disruption, addiction, withdrawal and morphine
4) Confidence 0.14 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.29 Pain Relevance 1.00

General Comments

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