INT78570

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 5.45
Pain Relevance 9.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
spinal 2
eye 1
neurons 1
brain 1
dorsal horn 1
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 123 100.00 Very High Very High Very High
antagonist 76 100.00 Very High Very High Very High
Glutamate 59 100.00 Very High Very High Very High
Glutamate receptor 28 100.00 Very High Very High Very High
alcohol 11 100.00 Very High Very High Very High
Arthritis 58 99.74 Very High Very High Very High
Nicotine 147 98.92 Very High Very High Very High
Dorsal horn 7 98.48 Very High Very High Very High
Lasting pain 3 98.16 Very High Very High Very High
agonist 11 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 19 100.00 Very High Very High Very High
Pain 119 99.84 Very High Very High Very High
Arthritis 98 99.74 Very High Very High Very High
Targeted Disruption 5 98.60 Very High Very High Very High
Hyperalgesia 11 97.58 Very High Very High Very High
Injury 29 96.92 Very High Very High Very High
Recurrence 1 96.88 Very High Very High Very High
Cv Unclassified Under Development 1 96.52 Very High Very High Very High
INFLAMMATION 14 92.92 High High
Depression 10 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, reducing mGluR5 receptor levels by 50 per cent in transgenic mice shifts the ocular dominance value towards the non-deprived eye with respect to control mice (Dolen & Bear 2008), suggesting a feed-forward role for the receptor in the reinforcement of plastic rearrangements in the binocular visual cortex after MD.


Negative_regulation (reducing) of mGluR5 in eye associated with targeted disruption
1) Confidence 0.57 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.15 Pain Relevance 0.19
Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.
Negative_regulation (blockade) of mGlu5 associated with lasting pain
2) Confidence 0.43 Published 2001 Journal Neuropharmacology Section Title Doc Link 11077065 Disease Relevance 0.87 Pain Relevance 1.00
Selective blockade of mGlu5 receptors in models of acute, persistent and <span style="background-color</span>:#FFA07A">chronic pain.
Negative_regulation (blockade) of mGlu5 associated with lasting pain
3) Confidence 0.43 Published 2001 Journal Neuropharmacology Section Title Doc Link 11077065 Disease Relevance 0.86 Pain Relevance 0.99
Furthermore, this hyperalgesia was also significantly attenuated by repeated i.p. injection of 6-methyl-2-[phenylethynyl]-pyridine (MPEP), a selective mGlu5 receptor inhibitor, once a day for a week after 4 weeks of ethanol treatment.
Negative_regulation (inhibitor) of mGlu5 associated with hyperalgesia
4) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17349994 Disease Relevance 0.57 Pain Relevance 0.85
We evaluated the ability of spinally administered 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), and 2-chloro-5-hydroxyphenylglycine (CHPG), an mGluR5 agonist, to modulate the antinociceptive action and tolerance of intrathecal (i.t.) morphine infusion in rats, and assessed the expression of spinal nitric oxide synthase (NOS).
Negative_regulation (antagonist) of mGluR5 in spinal associated with glutamate receptor, antagonist, tolerance, agonist, antinociceptive, morphine and intrathecal
5) Confidence 0.42 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18395342 Disease Relevance 0 Pain Relevance 1.03
Previous studies have shown that blockade of metabotropic glutamate 5 receptors (mGluR5) results in inhibition of nicotine self-administration in experimental animals.
Negative_regulation (blockade) of mGluR5 associated with glutamate and nicotine
6) Confidence 0.42 Published 2010 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC2885299 Disease Relevance 0 Pain Relevance 0.32
Recent studies have revealed the effectiveness of 2-methyl-6-(phenylethynyl)pyridine (MPEP), a highly selective antagonist of metabotropic glutamate receptors subtype 5 (mGluR5), in conditioned drug reward.
Negative_regulation (antagonist) of mGluR5 associated with glutamate receptor and antagonist
7) Confidence 0.42 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.24
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Negative_regulation (decreased) of mGluR5 in brain associated with ischemia
8) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.65 Pain Relevance 0.08
This correlated with a selective reduction in mGluR1, but not mGluR5, immunoreactivity in the superficial dorsal horn compared with untreated control rats, in parallel with a significant reduction in the proportion of neurons activated by the mGluR group I agonist 3, 5-dihydroxyphenylglycine (DHPG), whereas the proportion of cells excited by the mGluR5 agonist, trans-azetidine-2,4-dicarboxylic acid (t-ADA) remained unaffected.
Negative_regulation (reduction) of mGluR5 in dorsal horn associated with agonist and dorsal horn
9) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822771 Disease Relevance 0.15 Pain Relevance 0.65
These results provide direct functional evidence that blockade of peripheral mGluR5 receptors inhibits nociceptive transmission and support previous studies demonstrating a peripheral site of action associated with the antinociceptive effect of MPEP following inflammation.
Negative_regulation (blockade) of mGluR5 associated with nociception, inflammation and antinociceptive
10) Confidence 0.41 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16125843 Disease Relevance 0.33 Pain Relevance 0.33
mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation.
Negative_regulation (antagonist) of mGlu5 in spinal associated with pain and antagonist
11) Confidence 0.33 Published 2003 Journal Brain Res. Section Title Doc Link 12505681 Disease Relevance 0 Pain Relevance 0.57
In the arthritis pain model, blockade of mGluR1 and mGluR5 decreased the enhanced activity of CeLC neurons to normal-like levels, suggesting a major change in the function of mGluR1 in pain.
Negative_regulation (blockade) of mGluR5 in neurons associated with pain and arthritis
12) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.73 Pain Relevance 0.86
Like the mGluR1 antagonist, a selective mGluR5 antagonist (MTEP, 1 ?
Negative_regulation (selective) of mGluR5 associated with antagonist
13) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.54 Pain Relevance 0.56
Other drugs that reliably decrease alcohol intake in the FH/Wjd rats include the 5-hydroxytryptamine-2A receptor antagonist, amperozide, the mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and herbal derivatives such as ibogaine, St.
Negative_regulation (decrease) of mGlu5 associated with antagonist and alcohol
14) Confidence 0.23 Published 2006 Journal Addict Biol Section Abstract Doc Link 16961764 Disease Relevance 0.42 Pain Relevance 1.02
In this study, we demonstrated that DHPG-induced long-lasting potentiation of AMPA receptors-mediated sEPSC amplitude was completely blocked only when both mGluR1 and mGluR5 were blocked, indicating that a single subtype of group I mGluR is enough for the postsynaptic potentiating effect.
Negative_regulation (blocked) of mGluR5
15) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.09 Pain Relevance 0.38
Together, these data demonstrate that in the presence of Siah1a, the function of group I mGluRs is selectively inhibited.
Negative_regulation (inhibited) of mGluRs
16) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.11

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