INT78578

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 9.55
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
sensory neurons 3
neurons 2
sensory nerve 2
ureter 1
IB4 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 10 100.00 Very High Very High Very High
nociceptor 28 99.84 Very High Very High Very High
Visceral pain 10 99.76 Very High Very High Very High
Inflammation 42 99.28 Very High Very High Very High
Pain 143 98.86 Very High Very High Very High
dorsal root ganglion 219 98.72 Very High Very High Very High
medulla 4 98.40 Very High Very High Very High
adenocard 27 97.90 Very High Very High Very High
Neuropathic pain 15 97.20 Very High Very High Very High
unmyelinated 10 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 126 99.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 99.76 Very High Very High Very High
INFLAMMATION 38 99.28 Very High Very High Very High
Pain 151 98.86 Very High Very High Very High
Ganglion Cysts 468 98.72 Very High Very High Very High
Neuropathic Pain 33 97.20 Very High Very High Very High
Targeted Disruption 7 96.84 Very High Very High Very High
Pressure And Volume Under Development 5 96.72 Very High Very High Very High
Colitis 2 96.24 Very High Very High Very High
Nervous System Injury 10 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds.
Localization (Localization) of P2X3 in taste buds
1) Confidence 0.78 Published 1999 Journal Neuroreport Section Title Doc Link 10321492 Disease Relevance 0.09 Pain Relevance 0.13
Thus, sensitization of P2X3 receptors rather than a change in ATP release is responsible for the neuropathic pain behaviors.
Localization (sensitization) of P2X3 associated with neuropathic pain
2) Confidence 0.71 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 1.07 Pain Relevance 0.43
The P2X3 ion channel is localized on nociceptors of sensory neurons.
Localization (localized) of P2X3 in sensory neurons associated with nociceptor
3) Confidence 0.70 Published 2006 Journal Neuroreport Section Abstract Doc Link 16951565 Disease Relevance 0.20 Pain Relevance 0.47
In summary, our results suggest that P2X3 is expressed by a functionally heterogeneous population of BSI-B4-binding sensory neurons, and is transported into both central and peripheral processes of these neurons.
Localization (transported) of P2X3 in sensory neurons
4) Confidence 0.70 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.43
The P2X3 receptor subunit, a member of the P2X family of ATP-gated ion channels, is almost exclusively localized in sensory neurons.
Localization (localized) of P2X3 in sensory neurons
5) Confidence 0.70 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.07
Both patch-clamp recordings and immunocytochemistry coupled with confocal laser microscopy indicated a colocalization of functional P2X3 and P2Y1 receptors on the same DRG neurons.
Localization (colocalization) of P2X3 in neurons associated with dorsal root ganglion
6) Confidence 0.69 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749424 Disease Relevance 0.33 Pain Relevance 0.45
Then, the mRNA levels for P2X3 receptor and ?
Localization (receptor) of P2X3
7) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1557483 Disease Relevance 0.12 Pain Relevance 0.18
Analysis of the colocalization of P2X3-ir with cytochemical markers of DRG neurons indicated that approximately 94% of the P2X3-positive neuronal profiles were labelled by isolectin B4 from Bandeiraea simplicifolia, while only 3% contained substance P-ir, and 7% contained somatostatin-ir.
Localization (colocalization) of P2X3 in DRG associated with somatostatin and substance p
8) Confidence 0.66 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.40
Moreover, protein kinase A does not participate in the inhibition of P2X3 currents caused by PAR2 activation.
Localization (caused) of P2X3
9) Confidence 0.62 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.46 Pain Relevance 0.39
Next, because CysLT2-positive cells heavily co-localized with P2X3, we examined whether intraplantar injection of LTC4 can enhance the nocifensive behaviors induced by alpha, beta-methylene adenosine 5'-triphosphate (??
Localization (localized) of P2X3 associated with adenocard
10) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.43 Pain Relevance 0.54
ATP release and P2X3 and P2X2/3 receptor-mediated nociceptive sensory nerve responses were enhanced in a model of colitis consisting of administration to adult rats of an intrarectal enema of 30% trinitro benzene sulfonic acid in ethanol at a dose of 80 mg/kg body weight [67].
Localization (release) of P2X3 in sensory nerve associated with colitis, nociception and body weight
11) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 0.83 Pain Relevance 0.33
Interestingly, CysLT2 mRNA expressing neurons were heavily co-localized with TRPV1- or P2X3-positive neurons.
Localization (localized) of P2X3 in neurons
12) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.48 Pain Relevance 0.40
Real time amplification experiments showed that equivalent amount of samples (measured as GAPDH mRNA amplification levels) gave undetectable amplification of P2X2, P2X3 and TRPV1 mRNAs, indicating that the contribution of non-neuronal mRNAs to PCR experiments was minimal.
Localization (amplification) of P2X3 in neuronal
13) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.19 Pain Relevance 0
Since one characteristic feature of P2X3-containing receptors is their fast-developing desensitization [16], the current decay during application of ?
Localization (feature) of P2X3
14) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.11 Pain Relevance 0.15
The co-localization of P2Y4 and P2X3 receptors was less frequent than that of P2Y1 and P2Y4 receptors.
Localization (localization) of P2X3
15) Confidence 0.44 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.37 Pain Relevance 0.70
These data were confirmed by the finding that P2Y1 receptors are often co-localized on the same cells with P2X3 receptors [22].
Localization (localized) of P2X3
16) Confidence 0.41 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.99 Pain Relevance 0.43
PIP2 rescues P2X3 and P2X2 current responses from rundown in excised inside-out macropatches
Localization (responses) of P2X3
17) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites.
Localization (localization) of P2X3 purinoceptor in IB4 associated with nociceptor and neuropeptide
18) Confidence 0.22 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10103088 Disease Relevance 0.05 Pain Relevance 0.44
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Localization (released) of P2X3 in bladder associated with pain and visceral pain
19) Confidence 0.16 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.71 Pain Relevance 0.85
Following hints in the early literature about adenosine 5'-triphosphate (ATP) injections producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which was shown to be localized predominantly on small nociceptive sensory nerves.
Localization (localized) of P2X3 in sensory nerves associated with nociception, pain and adenocard
20) Confidence 0.15 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.27 Pain Relevance 0.36

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