INT78579

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 10.13
Pain Relevance 10.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
anterior 1
posterior 1
neuronal 1
hypothalamus 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 30 99.96 Very High Very High Very High
nociceptor 7 99.92 Very High Very High Very High
Pain 99 99.82 Very High Very High Very High
Snapping jaw 9 99.62 Very High Very High Very High
Sciatic nerve 8 99.62 Very High Very High Very High
Hyperalgesia 12 99.60 Very High Very High Very High
Dorsal horn 20 99.58 Very High Very High Very High
Peripheral nerve injury 8 99.56 Very High Very High Very High
dorsal rhizotomy 1 99.40 Very High Very High Very High
Cancer pain 10 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 9 99.62 Very High Very High Very High
Hyperalgesia 15 99.60 Very High Very High Very High
Nervous System Injury 44 99.12 Very High Very High Very High
Ganglion Cysts 29 99.00 Very High Very High Very High
Bone Cancer 12 98.68 Very High Very High Very High
Pain 116 98.48 Very High Very High Very High
Cv General 2 Under Development 99 97.96 Very High Very High Very High
Neuropathic Pain 82 97.88 Very High Very High Very High
Nociception 32 97.12 Very High Very High Very High
INFLAMMATION 132 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.
Negative_regulation (blockade) of P2X3 associated with pain, cancer pain and bone cancer
1) Confidence 0.59 Published 2010 Journal Brain Section Title Doc Link 20802203 Disease Relevance 0.71 Pain Relevance 1.06
Sequence specificity was shown by titration of mismatches to the original selected oligonucleotide, and this correlated with progressive loss of P2X3 inhibition.
Negative_regulation (inhibition) of P2X3
2) Confidence 0.59 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Abstract Doc Link 11446592 Disease Relevance 0.07 Pain Relevance 0.17
The ability to specifically downregulate the P2X3 receptor by ASO treatment will allow investigation of the biologic role of this receptor in neuronal tissues and eventually in in vivo models of chronic pain.
Negative_regulation (downregulate) of P2X3 in neuronal associated with lasting pain
3) Confidence 0.59 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Abstract Doc Link 11446592 Disease Relevance 0.15 Pain Relevance 0.19
Specific inhibition of the rat ligand-gated ion channel P2X3 function via methoxyethoxy-modified phosphorothioated antisense oligonucleotides.
Negative_regulation (inhibition) of P2X3
4) Confidence 0.59 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Title Doc Link 11446592 Disease Relevance 0.09 Pain Relevance 0.12
In order to obtain such a specific inhibitor, a variety of antisense oligonucleotides (ASO) against rat P2X3 was tested, and dose-dependent, sequence-specific downregulation of the rat P2X3 receptor (expressed in a Chinese hamster ovary cell line [CHO-K1]) on the mRNA, protein, and functional levels was observed.
Negative_regulation (downregulation) of P2X3 in ovary
5) Confidence 0.51 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Abstract Doc Link 11446592 Disease Relevance 0.09 Pain Relevance 0.09
These data suggest that blockade of P2X3 and P2X2/3 receptors on both the peripheral and central terminals of nocioceptors contributes to analgesic efficacy in a model of bone cancer pain.
Negative_regulation (blockade) of P2X3 associated with cancer pain, analgesic and bone cancer
6) Confidence 0.43 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.80 Pain Relevance 0.79
Using real-time quantitative PCR, a dose-dependent downregulation of P2X3 mRNA by ASO, as compared with untreated and mismatch controls, was demonstrated.
Negative_regulation (downregulation) of P2X3
7) Confidence 0.43 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Abstract Doc Link 11446592 Disease Relevance 0.08 Pain Relevance 0.11
All purinergic compounds produced an increase in excitability, however, only the effects of alpha,beta-meATP and of Ap5A were strongly reduced by 2'- (or 3') -O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), a selective blocker for P2X1, P2X3, and heteromeric P2X2/3 receptors.
Negative_regulation (blocker) of P2X3
8) Confidence 0.37 Published 2001 Journal Neuroreport Section Abstract Doc Link 11277562 Disease Relevance 0 Pain Relevance 0.25
Moreover, protein kinase A does not participate in the inhibition of P2X3 currents caused by PAR2 activation.
Negative_regulation (inhibition) of P2X3
9) Confidence 0.36 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.47 Pain Relevance 0.40
In dorsal horn of rat spinal cord, P2X3-ir was observed in the inner portion of lamina II and was reduced subsequent to dorsal rhizotomy, as well as subsequent to neonatal capsaicin treatment.
Negative_regulation (reduced) of P2X3 in lamina associated with qutenza, dorsal rhizotomy, dorsal horn and spinal cord
10) Confidence 0.35 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.47
IP5I effectively inhibited P2X3 currents when pre-exposed to desensitized but not unbound receptors.
Negative_regulation (inhibited) of P2X3
11) Confidence 0.32 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014755 Disease Relevance 0.46 Pain Relevance 0.59
Combined antisense and RNA interference-mediated treatment for specific inhibition of the recombinant rat P2X3 receptor appears to be promising for pain therapy [103].
Negative_regulation (inhibition) of P2X3 associated with pain
12) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 1.05 Pain Relevance 1.11
Transection of the sciatic nerve produces a marked reduction of P2X3-ir in injured DRG [121].
Negative_regulation (reduction) of P2X3 in sciatic nerve associated with sciatic nerve
13) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.88 Pain Relevance 0.66
For example, Zhao et al. showed that decreased PIP2 levels inhibited P2X3 currents in primary rat DRG neurons [52].
Negative_regulation (inhibited) of P2X3 in neurons associated with ganglion cysts
14) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.16 Pain Relevance 0
In the present study, we confirm that site-directed elimination of the potential phosphor-acceptor threonine or the basic residue in the P+2 position of the TXR/K sequence accelerates desensitization of P2X2 receptors and abolishes P2X3 receptor function.
Negative_regulation (abolishes) of P2X3
15) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072911 Disease Relevance 0.28 Pain Relevance 0.27
A-317491 was identified as a specific inhibitor for P2X2/3 and P2X3 receptors.
Negative_regulation (inhibitor) of P2X3
16) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.58 Pain Relevance 0.58
The time course of the reversal of hyperalgesia is consistent with downregulation of P2X3 receptor protein and function.
Negative_regulation (downregulation) of P2X3 receptor protein associated with hyperalgesia
17) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223568 Disease Relevance 0.84 Pain Relevance 0.89
Retrograde tracing confirmed that TMJ neurons in the TG exhibited P2X3R immunoreactivity.
Negative_regulation (exhibited) of P2X3R in neurons associated with snapping jaw
18) Confidence 0.11 Published 2005 Journal Pain Section Abstract Doc Link 15936887 Disease Relevance 0.94 Pain Relevance 1.32
P2X3 receptors are down-regulated following peripheral nerve injury and their expression can be regulated by GDNF.
Negative_regulation (down-regulated) of P2X3 in peripheral nerve associated with nervous system injury and peripheral nerve injury
19) Confidence 0.11 Published 1998 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 9828090 Disease Relevance 0.48 Pain Relevance 0.37
Glial cell line-derived neurotrophic factor (GDNF), delivered intrathecally, completely reversed axotomy-induced down-regulation of the P2X3 receptor.
Negative_regulation (down-regulation) of P2X3 in Glial cell
20) Confidence 0.11 Published 1998 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 9828090 Disease Relevance 0.41 Pain Relevance 0.37

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