INT78581

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 7.37
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
J82 2
nucleus 2
fibroblast 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 8 100.00 Very High Very High Very High
Inflammatory stimuli 5 99.96 Very High Very High Very High
Inflammation 87 97.40 Very High Very High Very High
cINOD 5 96.64 Very High Very High Very High
COX2 18 96.04 Very High Very High Very High
aspirin 4 88.16 High High
Glutamate 2 86.68 High High
antidepressant 2 85.40 High High
Paracetamol 2 81.96 Quite High
Inflammatory response 12 81.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 111 99.96 Very High Very High Very High
Hemophilus Infection 267 99.84 Very High Very High Very High
Cancer 58 99.56 Very High Very High Very High
Stress 10 98.40 Very High Very High Very High
Infection 36 89.40 High High
Toxicity 4 88.24 High High
Apoptosis 8 82.32 Quite High
Death 10 81.36 Quite High
Disease 10 81.16 Quite High
Pressure And Volume Under Development 1 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three chemicals induced Nrf2, but NF-kappaB binding activity was only increased after BSO treatment.
Positive_regulation (increased) of NF-kappaB Binding (binding) of
1) Confidence 0.66 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.54 Pain Relevance 0.13
Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro.
Positive_regulation (following) of Nuclear Factor-kappa B Binding (binding) of associated with inflammatory stimuli
2) Confidence 0.46 Published 2009 Journal Phytother Res Section Abstract Doc Link 19288476 Disease Relevance 0.57 Pain Relevance 0.21
All three chemicals induced Nrf2, but NF-kappaB binding activity was only increased after BSO treatment.
Positive_regulation (increased) of NF-kappaB Binding (activity) of
3) Confidence 0.44 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.54 Pain Relevance 0.13
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
Positive_regulation (induced) of NF-kappaB Binding (binding) of in nucleus
4) Confidence 0.44 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
Here we demonstrate that transcription from a promoter containing NF-kappaB binding sequences as well as the DNA binding activity of NF-kappaB were increased in PDGF-B-chain-transformed mouse fibroblast cells.
Positive_regulation (increased) of NF-kappaB Binding (activity) of in fibroblast
5) Confidence 0.42 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.25 Pain Relevance 0.17
Clonidine also significantly enhanced LPS-induced NF-kappaB activation by enhancing the nuclear translocation of NF-kappaB as well as increasing the NF-kappaB-DNA binding activity.
Positive_regulation (increasing) of NF-kappaB-DNA Binding (activity) of
6) Confidence 0.40 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
LPS treatment promoted specific binding of NF-kappaB to both COX-2 and mPGES-1 promoters.
Positive_regulation (promoted) of NF-kappaB Binding (specific) of
7) Confidence 0.39 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.35 Pain Relevance 0.16
To further confirm this finding, we tested whether the BCG-induced increased binding of NF-kappaB would lead to up-regulation of transcripts known to possess a p65 binding site.
Positive_regulation (increased) of NF-kappaB Binding (binding) of
8) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.09 Pain Relevance 0
In addition, BCG treatment of a human urothelial cancer cell line (J82) also increased the binding activity of NF-kappaB, as determined by precipitation of the chromatin by a NF-kappaB-p65 antibody and Q-PCR of genes bearing a NF-kappaB consensus sequence.
Positive_regulation (increased) of NF-kappaB Binding (binding) of in J82 associated with cancer
9) Confidence 0.31 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2262873 Disease Relevance 0.41 Pain Relevance 0.04
We next conducted electophoretic mobility shift assay (EMSA) to determine the DNA binding activity of nuclear factor kappa B (Nfkappab), an important upstream modulator for Nos2 expression, to find that fluoxetine increased DNA binding activity of Nfkappab.
Positive_regulation (increased) of nuclear factor kappa B Binding (activity) of associated with fluoxetine
10) Confidence 0.28 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.22 Pain Relevance 0.80
NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.
Positive_regulation (up) of NF-kappa B Binding (binding) of associated with hemophilus infection
11) Confidence 0.20 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.14 Pain Relevance 0
EMSA analysis showed that NF-kappa B translocation and its DNA binding activity were markedly increased by NTHi within 90 mins, and DNA binding activity of NF-kappa B was not affected by pre-treatment of specific p38 MAPK inhibitor SB203580.
Positive_regulation (increased) of NF-kappa B Binding (binding) of associated with hemophilus infection
12) Confidence 0.20 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.29 Pain Relevance 0
Up-regulation of NF-kappa B DNA binding activity after NTHi stimulation
Positive_regulation (regulation) of NF-kappa B Binding (binding) of associated with hemophilus infection
13) Confidence 0.20 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.28 Pain Relevance 0
We show that PBN inhibits lipopolysaccharide-mediated increase of NF-kappaB DNA binding activity with a lower concentration than that for the non-steroidal anti-inflammatory drug (NSAID), salicylate.
Positive_regulation (increase) of NF-kappaB Binding (activity) of associated with inflammation and cinod
14) Confidence 0.03 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9824673 Disease Relevance 0.32 Pain Relevance 0.58
We show that PBN inhibits lipopolysaccharide-mediated increase of NF-kappaB DNA binding activity with a lower concentration than that for the non-steroidal anti-inflammatory drug (NSAID), salicylate.
Positive_regulation (increase) of NF-kappaB Binding (binding) of associated with inflammation and cinod
15) Confidence 0.03 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9824673 Disease Relevance 0.32 Pain Relevance 0.58

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