INT78590

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Context Info
Confidence 0.00
First Reported 1998
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nos2, PTGS1) nucleus (Nos2, PTGS1) cytoplasm (Nos2, PTGS1)
lipid binding (PTGS1) extracellular space (Nos2) oxidoreductase activity (PTGS1)
Anatomy Link Frequency
macrophages 1
Nos2 (Rattus norvegicus)
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 8 99.92 Very High Very High Very High
Inflammation 7 99.80 Very High Very High Very High
cINOD 3 83.92 Quite High
antagonist 1 75.00 Quite High
cytokine 1 29.12 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.80 Very High Very High Very High
Necrosis 1 99.20 Very High Very High Very High
Cancer 1 99.02 Very High Very High Very High
Multiple Organ Failure 1 78.96 Quite High
Sepsis 1 77.88 Quite High
Disease 2 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the known pharmacological effects of PBN are primarily anti-inflammatory in nature, in this study we determined the inhibitory activities of PBN against two inflammatory factors: inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX2).
inducible nitric oxide synthase Positive_regulation (inducible) of cyclooxygenase associated with inflammation and cox2
1) Confidence 0.00 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9824673 Disease Relevance 0.26 Pain Relevance 0.34
We tested these PLA2 inhibitors for their ability to inhibit the production of tumor necrosis factor alpha (TNFalpha) and 2 enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in an assay system using lipopolysaccharide (LPS)-stimulated Raw264.7 macrophages.
inducible nitric oxide synthase Positive_regulation (inducible) of cyclooxygenase in macrophages associated with necrosis and cancer
2) Confidence 0.00 Published 1999 Journal Shock Section Abstract Doc Link 10588517 Disease Relevance 0.59 Pain Relevance 0.16

General Comments

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