INT78619

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 10.43
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
endothelial cells 4
epithelial cells 1
MCF7 1
monocytes 1
filaments 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 3 99.92 Very High Very High Very High
lidocaine 1 99.16 Very High Very High Very High
Opioid 19 98.52 Very High Very High Very High
antagonist 11 97.94 Very High Very High Very High
Pain 9 96.52 Very High Very High Very High
Botox 51 92.08 High High
aspirin 8 91.76 High High
cINOD 39 90.64 High High
metalloproteinase 822 86.60 High High
cytokine 646 84.16 Quite High
Disease Link Frequency Relevance Heat
Adhesions 402 99.80 Very High Very High Very High
Diffuse Esophageal Spasm 1 99.80 Very High Very High Very High
Apoptosis 99 99.50 Very High Very High Very High
Herpes Simplex Virus 1904 98.98 Very High Very High Very High
Stress 27 98.72 Very High Very High Very High
Malignant Neoplastic Disease 52 98.50 Very High Very High Very High
Infection 880 98.28 Very High Very High Very High
Pain 8 96.52 Very High Very High Very High
Skin Cancer 7 94.88 High High
Breast Cancer 55 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, we showed that in Swiss 3T3 cells, pomalidomide only activated RhoA, not Rac1 or Cdc42, and potently induced stress fiber formation.
Neg (not) Positive_regulation (activated) of Rac1 associated with stress
1) Confidence 0.65 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.17 Pain Relevance 0.08
Using pomalidomide and primary human monocytes, we report that pomalidomide rapidly and selectively activated RhoA and Rac1, but not Cdc42 or Ras, in the absence of any costimulation.
Positive_regulation (activated) of Rac1 in monocytes
2) Confidence 0.65 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.09
This effect was regulated by early phosphorylation of FAK and subsequent PI-3K and Rac1 activation.
Positive_regulation (activation) of Rac1
3) Confidence 0.59 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.32 Pain Relevance 0.14
We have recently identified a specific signaling pathway that regulates actin reorganization in malignant human breast and prostate epithelial cells associated with FAK, PI-3K and Rac1 activation.
Positive_regulation (activation) of Rac1 in epithelial cells associated with malignant neoplastic disease
4) Confidence 0.59 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.23 Pain Relevance 0.09
Pretreatment of MCF7 cells with the specific PI-3 kinase inhibitor wortmannin abolished both the activation of Rac1 and actin reorganization, while the opioid-induced phosphorylation of FAK and vinculin remained unaffected.
Positive_regulation (activation) of Rac1 in MCF7 associated with malignant neoplastic disease and opioid
5) Confidence 0.55 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.67 Pain Relevance 0.78
In addition, a substantial activation of the small GTPase Rac1 was observed.
Positive_regulation (activation) of Rac1
6) Confidence 0.55 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.70 Pain Relevance 0.71
[Injection of botulinum toxin for diffuse esophageal spasm].
Positive_regulation ([Injection) of botulinum toxin associated with diffuse esophageal spasm
7) Confidence 0.50 Published 2005 Journal Dtsch. Med. Wochenschr. Section Title Doc Link 15692899 Disease Relevance 0.29 Pain Relevance 0.10
The small GTPase Rac1 is highly induced and this was confirmed by immunoblotting.
Positive_regulation (induced) of Rac1
8) Confidence 0.46 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 14976132 Disease Relevance 0.49 Pain Relevance 0.31
Plitidepsin is a COMPARE negative compound, whose main mechanism of action remains to be fully elucidated, although evidence suggests that oxidative stress [10], and decreased intracellular levels of glutathione ultimately lead to both caspases-dependant and independent cellular apoptosis induction [11], whereas activation of the Rac1-JNK pathway plays a major role [12,13].
Positive_regulation (activation) of Rac1 associated with stress and apoptosis
9) Confidence 0.45 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2763111 Disease Relevance 0.41 Pain Relevance 0.03
Two types of local agents have been used in addition to the newly emerged botulinum toxin: local anesthetics (lidocaine and congeners), with a fully reversible action of short duration, and alcohols (ethanol and phenol), with a longer duration of action.
Positive_regulation (emerged) of botulinum toxin associated with lidocaine and local anesthetic
10) Confidence 0.41 Published 1997 Journal Muscle Nerve Suppl Section Abstract Doc Link 9826983 Disease Relevance 0.56 Pain Relevance 0.47
Treatment with the opioid antagonist alpha(s1) casomorphin resulted in rapid and potent actin remodeling in A375 cells, regulated by rapid activation of the FAK/PI-3K/Rac1 signaling.
Positive_regulation (activation) of Rac1 in A375 associated with antagonist and opioid
11) Confidence 0.39 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.33 Pain Relevance 0.15
KSHV-PGE2 regulated endothelial cell adhesion involves Rac1 activation
Positive_regulation (activation) of Rac1 in endothelial cell associated with herpes simplex virus and adhesions
12) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.55 Pain Relevance 0
PGE2, secreted early during KSHV infection, profoundly increased the adhesion of uninfected endothelial cells to fibronectin by activating the small G protein Rac1.
Positive_regulation (activating) of Rac1 in endothelial cells associated with herpes simplex virus, adhesions and infection
13) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.72 Pain Relevance 0.30
RhoA and Rac1-GTPase activity by G-LISA activation assay
Positive_regulation (activation) of Rac1
14) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.16 Pain Relevance 0
HMVEC-d cells plated on fibronectin coated plates cultured in the presence of the supernatant obtained from the 2h infected cell showed 2.5-fold activation of Rac1 which was completely abrogated (100% inhibition) in the presence of supernatant prepared from NS-398 pretreated and then infected endothelial cells (Figure 10K, lanes 1–3).
Positive_regulation (activation) of Rac1 in endothelial cells
15) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.22 Pain Relevance 0
Induction of Rac1-GTPase was 4.8- fold when compared to Rac1-GTPase activity in the presence of uninfected cell culture supernatant suggesting that PGE2 is enough to induce Rac1-GTPase in the adhering endothelial cells.
Positive_regulation (Induction) of Rac1 in endothelial cells
16) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.24 Pain Relevance 0
We observed 2.7, 3.8, 4.4 and 4.2- fold Rac1-GTPase activation upon plating cells in the presence of infected cell culture supernatant for 15?
Positive_regulation (activation) of Rac1
17) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.33 Pain Relevance 0
About 1.8, 2, 3 and 2.5- fold activation of Rac1-GTPase was observed at 15?
Positive_regulation (activation) of Rac1
18) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.11 Pain Relevance 0
Stimulation of Rac1 activity in PGE2 stimulated HMVEC-d cells grown on fibronectin plates was comparable to the activity observed in the presence of infected cell culture supernatant (Figure 10K, lanes 3 and 4).
Positive_regulation (Stimulation) of Rac1 in d cells
19) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.34 Pain Relevance 0.06
12 can also activate JNK via ASK1, independently of the activation of Rac1 and cdc42 [39].
Positive_regulation (activation) of Rac1
20) Confidence 0.19 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.22

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