INT78626

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.30
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 2
sensory neurons 1
cerebrospinal fluid 1
astrocytes 1
mere 1
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 7 100.00 Very High Very High Very High
Migraine 14 99.52 Very High Very High Very High
Fibrositis 8 99.52 Very High Very High Very High
Analgesic 4 99.52 Very High Very High Very High
dorsal root ganglion 16 98.36 Very High Very High Very High
Acupuncture 7 97.04 Very High Very High Very High
Action potential 2 96.36 Very High Very High Very High
midbrain 5 96.32 Very High Very High Very High
Hippocampus 1 95.64 Very High Very High Very High
Nerve growth factor 17 94.84 High High
Disease Link Frequency Relevance Heat
Headache 20 99.52 Very High Very High Very High
Urological Neuroanatomy 1 99.40 Very High Very High Very High
Fibromyalgia 6 99.00 Very High Very High Very High
Ganglion Cysts 17 97.88 Very High Very High Very High
Parkinson's Disease 82 88.48 High High
Toxicity 16 88.08 High High
Migraine Without Aura 1 87.68 High High
Targeted Disruption 11 80.76 Quite High
Nociception 3 70.56 Quite High
Gliosis 4 20.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that IB(4)-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas IB(4)-negative neurons depend on NGF for survival during postnatal development (Molliver et al., 1997).
Regulation (depend) of GDNF in neurons
1) Confidence 0.45 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10414978 Disease Relevance 0.13 Pain Relevance 0.40
We also show that isolectin B4 (IB4)-positive neurons, many of which are responsive to GDNF, exhibited significantly lower thresholds to mechanical stimulation relative to wild-type neurons.
Regulation (responsive) of GDNF in neurons
2) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.17 Pain Relevance 0.72
Glia-derived neurotrophic factor (GDNF) was not significantly affected.
Neg (not) Regulation (affected) of neurotrophic factor
3) Confidence 0.26 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620518 Disease Relevance 0.10 Pain Relevance 0.52
Perhaps it is not a mere coincidence that the
               same receptor positively regulates the formation of GDNF and TGF-?. 
Regulation (regulates) of GDNF in mere
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.08
Application of LY379268 to
                   quiescent astrocytes (not shown) or astrocytes made
                   “reactive” by several passages in culture and by the G5
                   supplement in the medium did not affect GDNF levels (Fig. 6D).

4.

Neg (not) Regulation (affect) of GDNF in astrocytes
5) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.31 Pain Relevance 0.04
This investigation studied the temporal changes in the expression of GDNF and FGF-2 in the left sixth lumbar (L6) dorsal root ganglion (DRG) after acupuncture in adult cats subjected to unilateral removal of adjacent DRG.
Regulation (changes) of GDNF in DRG associated with ganglion cysts, dorsal root ganglion and acupuncture
6) Confidence 0.06 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15925097 Disease Relevance 0.52 Pain Relevance 0.46
Glial cell line-derived neurotrophic factor and somatostatin levels in cerebrospinal fluid of patients affected by chronic migraine and fibromyalgia.
Regulation (affected) of neurotrophic factor in cerebrospinal fluid associated with analgesic, migraine, somatostatin and fibrositis
7) Confidence 0.01 Published 2006 Journal Cephalalgia Section Title Doc Link 16556241 Disease Relevance 1.67 Pain Relevance 2.06
The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.
Regulation (effects) of neurotrophic factor in sensory neurons
8) Confidence 0.01 Published 1998 Journal Mol. Cell. Neurosci. Section Title Doc Link 9828090 Disease Relevance 0.41 Pain Relevance 0.34

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