INT78646

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.78
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
MCF7 1
MCF-7 1
CHO 1
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 20 100.00 Very High Very High Very High
Immobilon 3 100.00 Very High Very High Very High
MU agonist 2 99.84 Very High Very High Very High
Opioid 10 89.64 High High
Neuropeptide 2 85.68 High High
Serotonin 23 85.24 High High
antidepressant 90 76.44 Quite High
fluoxetine 17 73.00 Quite High
sSRI 36 71.96 Quite High
nMDA receptor 28 68.08 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 53 99.06 Very High Very High Very High
Breast Cancer 13 98.36 Very High Very High Very High
Cancer 30 94.24 High High
Disease 130 89.12 High High
Targeted Disruption 32 82.84 Quite High
Death 14 80.84 Quite High
Cerebral Amyloid Angiopathy 2 69.68 Quite High
Depression 78 66.52 Quite High
Amyloid Plaque 14 64.00 Quite High
Anxiety Disorder 1 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems.
Regulation (Modulation) of pS2 in MCF7 associated with mu agonist, breast cancer and immobilon
1) Confidence 0.20 Published 1998 Journal J. Cell. Biochem. Section Title Doc Link 9831078 Disease Relevance 0.19 Pain Relevance 0.67
MCF-7 cells over-expressing clusterin retain their sensitivity to both estrogens and anti-estrogens as assessed by monitoring the changes in the steady state level of the estrogen target gene, pS2, by real time PCR (Figure 1 panel E).
Regulation (changes) of pS2 in MCF-7
2) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0 Pain Relevance 0
peptide forming the dimer and trimer has been confirmed by amino acid sequencing.18 When CHO cells coexpress APP and a FAD-linked mutant PS1 or PS2 gene, oligomeric A?
Regulation (linked) of PS2 gene in CHO
3) Confidence 0.12 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 0.45 Pain Relevance 0
Moderate elevation in levels of intracellular amyloid peptide load leads to over expression in CREB responsive genes such as BDNF, presenilin 1 and presenilin 2.
Regulation (responsive) of presenilin 2 associated with alzheimer's dementia and bdmf
4) Confidence 0.03 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.14 Pain Relevance 0.74

General Comments

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