INT78649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.90
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
Notch 1
MCF7 1
heart 1
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
MU agonist 2 100.00 Very High Very High Very High
Immobilon 3 98.76 Very High Very High Very High
Opioid 10 94.04 High High
Neuropeptide 1 90.08 High High
cINOD 10 41.96 Quite Low
sodium channel 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 100.00 Very High Very High Very High
Disease 371 99.98 Very High Very High Very High
Dilated Cardiomyopathy 1 99.08 Very High Very High Very High
Cancer 1 98.64 Very High Very High Very High
Alzheimer's Dementia 36 98.32 Very High Very High Very High
Myocardial Infarction 5 98.00 Very High Very High Very High
Apoptosis 25 94.32 High High
Double Outlet Right Ventricle 1 93.20 High High
Ventricular Heart Septal Defects 1 91.84 High High
Targeted Disruption 70 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But interestingly, FAD-associated variant PS2N141I is able to rescue Notch-associated developmental defects compared to PS2 wt in the absence of PS1, which makes the precise functions of different PS/?
PS2 Binding (associated) of in Notch associated with disease
1) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.83 Pain Relevance 0
PSEN genes encode polytopic membrane proteins termed presenilins (PS1 and PS2), which function as the catalytic subunit of ?
PS2 Binding (termed) of
2) Confidence 0.33 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.64 Pain Relevance 0
In many instances the physiological role for the identified interaction between the putative protein with PS1 or PS2 is not clearly defined.
PS2 Binding (interaction) of
3) Confidence 0.33 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.56 Pain Relevance 0
Since the first prediction of a genetic link between PSEN1 and PSEN2 with Alzheimer's disease, many research groups from both academia and pharmaceutical industry have sought to unravel how pathogenic mutations in PSEN cause presenile dementia.
PSEN2 Binding (link) of associated with alzheimer's dementia and disease
4) Confidence 0.33 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.47 Pain Relevance 0
As discussed below, PS1 and PS2 are subunits of a protein complex, termed ?
PS2 Binding (subunits) of
5) Confidence 0.33 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 1.03 Pain Relevance 0
PS1 and PS2 mutations are associated with a higher risk of dilated cardiomyopathy and heart failure in AD patients [14].
PS2 Binding (associated) of in heart associated with dilated cardiomyopathy, disease and myocardial infarction
6) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.17 Pain Relevance 0
Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems.
pS2 Binding (interaction) of in MCF7 associated with mu agonist, breast cancer and immobilon
7) Confidence 0.12 Published 1998 Journal J. Cell. Biochem. Section Title Doc Link 9831078 Disease Relevance 0.20 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox