INT78658

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.46
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGIR) cell-cell signaling (PTGIR) signal transducer activity (PTGIR)
Anatomy Link Frequency
artery 1
umbilical artery 1
platelet 1
endothelium 1
vein 1
PTGIR (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 10 96.88 Very High Very High Very High
Inflammatory mediators 6 96.48 Very High Very High Very High
Inflammatory response 2 96.12 Very High Very High Very High
Inflammation 43 91.72 High High
agonist 19 90.52 High High
Pain 16 89.88 High High
cINOD 48 89.64 High High
cytokine 5 85.84 High High
interstitial cystitis 2 73.24 Quite High
diclofenac 25 58.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 59 96.08 Very High Very High Very High
Pathologic Processes 1 96.08 Very High Very High Very High
Disease 73 95.68 Very High Very High Very High
Pain 20 89.88 High High
Pressure And Volume Under Development 7 89.52 High High
Pre-eclampsia 99 89.36 High High
Interstitial Cystitis 2 73.24 Quite High
Increased Venous Pressure Under Development 44 72.00 Quite High
Hyperplasia 1 70.88 Quite High
Adhesions 2 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, PGD2, prostacyclin (PGI2), and thromboxane(TX) A2 – that are immediately released outside the cell after intracellular biosynthesis and modulate a wide variety of physiologic and pathologic processes via the interaction with specific receptors expressed mostly on the surface of target cells (Narumiya et al 1999; Breyer et al 2001).
Localization (released) of prostacyclin associated with pathologic processes
1) Confidence 0.18 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.42 Pain Relevance 0.41
This is particularly likely in large blood vessels, where, under physiological conditions, the release of prostacyclin by COX-1, present in the endothelium, is an important component of cardiovascular homeostasis.
Localization (release) of prostacyclin in endothelium
2) Confidence 0.13 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.58 Pain Relevance 0.29
The basal release of NO from the artery is approximately five times greater than that of PGI2.
Localization (release) of PGI2 in artery
3) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.14 Pain Relevance 0
In perfused segments of human umbilical artery and vein with intact endothelium the relative release of PGI2 and NO has been compared, utilizing the cascade bioassay.
Localization (release) of PGI2 in vein
4) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0
Molecules important for normal physiology, such as vasoactive substance prostacyclin (PGI2) and thromboxane A2 (TXA2), are metabolized in the same system as well.
Localization (metabolized) of PGI2
5) Confidence 0.09 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.65 Pain Relevance 0.23
Thrombin and tryptase stimulation resulted in activation of a Ca(2+)-independent PLA(2), leading to increased release of arachidonic acid and prostacyclin and increased production of platelet-activating factor.
Localization (release) of prostacyclin in platelet
6) Confidence 0.09 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15561975 Disease Relevance 0.48 Pain Relevance 0.30
Hence, collectively, both NO-donors and the vasodilatory prostanoids prostacyclin and PGD2 readily desensitize TP-mediated Rho activation and cytoskeletal signaling in 1° h.AoSMCs, findings entirely predicted from and in keeping with outcomes from other systems [6,8,35,36].
Localization (desensitize) of prostacyclin
7) Confidence 0.05 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
In perfused segments of human umbilical artery and vein with intact endothelium the relative release of PGI2 and NO has been compared, utilizing the cascade bioassay.
Localization (release) of PGI2 in umbilical artery
8) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0

General Comments

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