INT78659

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Context Info
Confidence 0.28
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 22
Disease Relevance 14.34
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brains 3
neurons 1
pancreas 1
Thim (Mus musculus)
Thim - R122H (3) Thim - N34S (1)
Pain Link Frequency Relevance Heat
Migraine 11 99.52 Very High Very High Very High
hypoalgesia 30 99.32 Very High Very High Very High
Central grey 162 99.14 Very High Very High Very High
Chronic pancreatitis 398 99.02 Very High Very High Very High
fibrosis 53 97.68 Very High Very High Very High
Inflammation 56 96.84 Very High Very High Very High
Neuritis 3 90.72 High High
Calcium channel 1 90.40 High High
Hippocampus 54 89.48 High High
Pain 40 87.04 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 122 99.98 Very High Very High Very High
Amyloidosis 1 99.84 Very High Very High Very High
Migraine With Aura 11 99.52 Very High Very High Very High
Syndrome 100 99.36 Very High Very High Very High
Hypoalagesia 30 99.32 Very High Very High Very High
Pancreatitis 601 99.24 Very High Very High Very High
Urological Neuroanatomy 162 99.14 Very High Very High Very High
Gallstones 249 98.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 98.68 Very High Very High Very High
Blepharophimosis 2 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our finding of augmented MOR density in the PAG and CPU regions in adult rats, which were exposed to THIM in early postnatal life, resembles the study results of Zanoli et al. [12] in the brains of rats exposed to methylmercury in utero.
Gene_expression (exposed) of THIM in brains associated with central grey
1) Confidence 0.28 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.38 Pain Relevance 0.43
At higher doses of THIM, statistically significant increases of MOR density were observed in this brain region.
Gene_expression (doses) of THIM in brain
2) Confidence 0.28 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.42 Pain Relevance 0.53
Characteristic ischemic-like degeneration of neurons and dark neurons were observed in the granular layer of the DG area, CA1 and CA3 fields in THIM-treated rats.
Gene_expression (fields) of THIM in neurons
3) Confidence 0.24 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0 Pain Relevance 0.04
The brains of the control rats and those treated with higher doses of THIM (1,440 and 3,000 ?
Gene_expression (doses) of THIM in brains
4) Confidence 0.24 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.47 Pain Relevance 0.23
g Hg/kg; c THIM dose 240 ?
Gene_expression (dose) of THIM
5) Confidence 0.24 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0 Pain Relevance 0.04
Each animal was weighed before THIM injection, and the amount of the drug given was adjusted to its weight.
Gene_expression (injection) of THIM
6) Confidence 0.24 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0 Pain Relevance 0
We were not able to analyze the entire MEFV gene, but detected only a heterozygous M694I mutation.
Gene_expression (detected) of mutation (M694I)
7) Confidence 0.02 Published 2006 Journal Intern. Med. Section Abstract Doc Link 16702743 Disease Relevance 0.62 Pain Relevance 0.08
The PCR products were denatured and reannealed to generate heteroduplexes in those samples where an ENU-induced point mutation was present.
Gene_expression (present) of mutation
8) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
The R122H mutation and a second MfeI side on the backbone vector were introduced by site directed mutagenesis using standard techniques (Quickchange Stratagene, Cedar Creek, TE, US).
Gene_expression (introduced) of mutation (R122H)
9) Confidence 0.01 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.10 Pain Relevance 0
The R122H mutation of the cationic trypsinogen was found in patients with hereditary pancreatitis.
Gene_expression (found) of mutation (R122H) associated with pancreatitis
10) Confidence 0.01 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1637108 Disease Relevance 0.51 Pain Relevance 0.03
In addition, a multidrug resistance 3 gene mutation in exon 14 has been recently detected in a patient who developed cholelithiasis in adolescence, followed by cholestasis of pregnancy and finally adulthood biliary cirrhosis [31].
Gene_expression (detected) of mutation associated with biliary liver cirrhosis and gallstones
11) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.54 Pain Relevance 0.11
Finally, more recent data shows that the LPAC syndrome is more frequent in females and that biliary symptoms occur earlier in female who present a nonsense mutation [6].


Gene_expression (present) of mutation associated with syndrome and gallstones
12) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.34 Pain Relevance 0
These mutations are indeed detected at high frequency in patients with LPAC syndrome; they affect only highly conserved amino acids between human and rodent homologues of the gene and no mutation was detected in an independent control panel of 140 chromosomes.
Gene_expression (detected) of mutation associated with syndrome and gallstones
13) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 0.61 Pain Relevance 0
Transgenic expression of the R122H mutation of murine trypsin 4 in mouse pancreas led to progressive fibrosis and chronic inflammation of the pancreas [72].
Gene_expression (expression) of R122H mutation (R122H) in pancreas associated with targeted disruption, fibrosis and inflammation
14) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.00 Pain Relevance 0.17
This mutation was predominantly found in patients with idiopathic chronic pancreatitis.
Gene_expression (found) of mutation associated with chronic pancreatitis
15) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.91 Pain Relevance 0.61
Some authors state that compound heterozygous CFTR carriers have a distinct elevated risk for the development of chronic pancreatitis, which is even higher when an additional SPINK1 mutation is present [51,54].
Gene_expression (present) of mutation associated with chronic pancreatitis
16) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.97 Pain Relevance 0.66
Neither mutation was detected in two hereditary pancreatitis families from Brazil [58] and no hereditary pancreatitis cases have been reported from Africa.
Neg (Neither) Gene_expression (detected) of mutation associated with pancreatitis
17) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.58 Pain Relevance 0.16
Initially, blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) was suspected; however, mutation of the FOXL2 gene was not detected.
Neg (not) Gene_expression (detected) of mutation associated with syndrome, ocular toxicity (including many sub-types) and blepharophimosis
18) Confidence 0.00 Published 2008 Journal Clin. Genet. Section Abstract Doc Link 18492087 Disease Relevance 1.54 Pain Relevance 0.17
However, the significance of the detection of this mutation in specimens obtained by needle aspiration from pure pancreatic juice and from stools for its utilization for the detection of early pancreatic cancer, and differentiation pancreatic cancer from chronic pancreatitis remains controversial.
Gene_expression (detection) of mutation
19) Confidence 0.00 Published 2004 Journal World J. Gastroenterol. Section Body Doc Link 14966900 Disease Relevance 0.22 Pain Relevance 0
The M731T mutation was found in a family with pure FHM.
Gene_expression (found) of mutation (M731T) associated with migraine
20) Confidence 0.00 Published 2003 Journal Ann. Neurol. Section Abstract Doc Link 12953268 Disease Relevance 1.14 Pain Relevance 0.99

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