INT78672

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.67
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
neuronal 2
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 32 99.84 Very High Very High Very High
Morphine 18 99.76 Very High Very High Very High
opioid receptor 3 99.68 Very High Very High Very High
lidocaine 3 99.60 Very High Very High Very High
antagonist 10 99.36 Very High Very High Very High
narcan 4 99.28 Very High Very High Very High
local anesthetic 3 99.10 Very High Very High Very High
mu opioid receptor 3 98.80 Very High Very High Very High
tetrodotoxin 3 97.68 Very High Very High Very High
addiction 6 92.16 High High
Disease Link Frequency Relevance Heat
Drug Dependence 6 92.56 High High
Substance Withdrawal Syndrome 1 84.16 Quite High
Anxiety Disorder 1 69.56 Quite High
Opiate Addiction 3 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine-dependent and -withdrawn mice.
Negative_regulation (abolished) of Gene_expression (expression) of DBI mRNA associated with narcan and morphine
1) Confidence 0.43 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.82
Continuous exposure to DAMGO also significantly increased DBI mRNA expression, which was completely abolished by a selective antagonist of mu-opioid receptors, beta-funaltrexamine (beta-FNA).
Negative_regulation (abolished) of Gene_expression (expression) of DBI mRNA associated with antagonist and mu opioid receptor
2) Confidence 0.43 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.96
Agents that stabilize the neuronal membrane, including tetrodotoxin (TTX), procainamide (a Na(+) channel inhibitor), and local anesthetics (dibucaine and lidocaine), dose-dependently inhibited the increased expression of DBI mRNA by nicotine.
Negative_regulation (inhibited) of Gene_expression (expression) of DBI mRNA in neuronal associated with tetrodotoxin, nicotine, lidocaine and local anesthetic
3) Confidence 0.40 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.77
In the cases of nicotine- and morphine-dependent mice, concomitant administration of antagonists for nicotinic acetylcholine and opioid receptors, respectively, abolished the increase in DBI expression.
Negative_regulation (abolished) of Gene_expression (expression) of DBI associated with antagonist, nicotine, opioid receptor and morphine
4) Confidence 0.38 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11288485 Disease Relevance 0.67 Pain Relevance 0.85
Nicotine-induced (0.1 microM) increases in DBI mRNA expression were abolished by hexamethonium, a nicotinic acetylcholine (nACh) receptor antagonist.
Negative_regulation (abolished) of Gene_expression (expression) of DBI mRNA associated with antagonist and nicotine
5) Confidence 0.29 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.58
The nicotine-induced increase in DBI mRNA expression was inhibited by L-type voltage-dependent Ca(2+) channel (VDCC) inhibitors such as verapamil, calmodulin antagonist (W-7), and Ca(2+)/calmodulin-dependent protein kinase II (CAM II kinase) inhibitor (KN-62), whereas P/Q- and N-type VDCC inhibitors showed no effects.
Negative_regulation (inhibited) of Gene_expression (expression) of DBI mRNA associated with antagonist and nicotine
6) Confidence 0.29 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.77

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