INT78675

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 34
Disease Relevance 12.93
Pain Relevance 23.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
neurons 5
brain 5
neuronal 2
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 102 99.84 Very High Very High Very High
narcan 15 99.76 Very High Very High Very High
addiction 125 99.64 Very High Very High Very High
Morphine 93 99.58 Very High Very High Very High
withdrawal 75 99.50 Very High Very High Very High
opioid receptor 22 99.26 Very High Very High Very High
lidocaine 6 99.12 Very High Very High Very High
alcohol 30 99.06 Very High Very High Very High
local anesthetic 6 98.62 Very High Very High Very High
mu opioid receptor 12 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 125 99.84 Very High Very High Very High
Opiate Addiction 59 97.88 Very High Very High Very High
Substance Withdrawal Syndrome 8 95.92 Very High Very High Very High
Anxiety Disorder 20 93.52 High High
Repression 6 89.12 High High
Disorder Of Lipid Metabolism 6 85.04 High High
Metabolic Syndrome 69 71.32 Quite High
Insulin Resistance 75 60.88 Quite High
Fatty Liver 189 38.64 Quite Low
Nash(non-alcoholic Steatohepatitis) 81 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that a chronic functional interaction between morphine and opioid receptors has a critical role in increases in DBI mRNA expression.
Gene_expression (expression) of DBI mRNA associated with opioid receptor and morphine
1) Confidence 0.78 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.77
Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine-dependent and -withdrawn mice.
Gene_expression (expression) of DBI mRNA associated with narcan and morphine
2) Confidence 0.78 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.81
Cerebral DBI mRNA expression significantly increased in morphine-dependent mice, and this increase is more remarkable in morphine-withdrawn mice, whereas a single administration of morphine (50 mg/kg) produced no changes in the expression.
Gene_expression (expression) of DBI mRNA associated with morphine
3) Confidence 0.78 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.74
Continuous exposure to DAMGO also significantly increased DBI mRNA expression, which was completely abolished by a selective antagonist of mu-opioid receptors, beta-funaltrexamine (beta-FNA).
Gene_expression (expression) of DBI mRNA associated with antagonist and mu opioid receptor
4) Confidence 0.78 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.95
The morphine-induced increase in DBI mRNA expression and its content were completely inhibited by naloxone and beta-FNA, and the inhibitory potential of naloxonazine was about half that of beta-FNA.
Gene_expression (expression) of DBI mRNA associated with narcan and morphine
5) Confidence 0.78 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 1.04
These results indicate that withdrawal from nicotine after its long-term exposure induces steep increase of DBI mRNA expression as reported previously in ethanol- and morphine-dependent animals.
Gene_expression (expression) of DBI mRNA associated with nicotine, withdrawal and morphine
6) Confidence 0.78 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11750077 Disease Relevance 0 Pain Relevance 0.58
The levels of DBI protein and its mRNA significantly increased in the brain derived from mice dependent on alcohol (ethanol), nicotine and morphine, and abrupt cessation of these drugs facilitated further increase in DBI expression.
Gene_expression (expression) of DBI in brain associated with nicotine, morphine and alcohol
7) Confidence 0.68 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11288485 Disease Relevance 0.70 Pain Relevance 0.86
In the cases of nicotine- and morphine-dependent mice, concomitant administration of antagonists for nicotinic acetylcholine and opioid receptors, respectively, abolished the increase in DBI expression.
Gene_expression (expression) of DBI associated with antagonist, nicotine, opioid receptor and morphine
8) Confidence 0.68 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11288485 Disease Relevance 0.66 Pain Relevance 0.84
Abrupt cessation of administration of drugs facilitated further increase in DBI expression.
Gene_expression (expression) of DBI
9) Confidence 0.68 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233989 Disease Relevance 0.91 Pain Relevance 0.95
Cerebral DBI expression significantly increases in animals with drug dependence induced by these drugs, and in the cases of nicotine- and morphine-dependent mice concomitant administration of antagonists for nicotinic acetylcholine and opioid receptors, respectively, abolished the increase.
Gene_expression (expression) of DBI associated with drug dependence, addiction, antagonist, nicotine, opioid receptor and morphine
10) Confidence 0.68 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233989 Disease Relevance 1.04 Pain Relevance 0.95
Similar patterns of DBI expression were observed in the neurons after sustained exposure to these drugs and its removal from culture medium.
Gene_expression (expression) of DBI in neurons
11) Confidence 0.68 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.76 Pain Relevance 0.75
In addition, the increase in DBI expression was completely blocked by L-type HVCC inhibitors.
Gene_expression (expression) of DBI
12) Confidence 0.68 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.71 Pain Relevance 0.70
Abrupt cessation of these drugs facilitated further increases in DBI expression.
Gene_expression (expression) of DBI
13) Confidence 0.68 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.73 Pain Relevance 0.75
These results indicate that the increase in DBI expression is induced by continuous activation of mu-opioid receptors but not of kappa- and delta-opioid receptors and is regulated by the calcium/calmodulin-related phosphorylation system.
Gene_expression (expression) of DBI associated with mu opioid receptor and delta opioid receptors
14) Confidence 0.68 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.93
Withdrawal from nicotine Increased DBI mRNA expression in cerebral cortices derived from nicotine-dependent mice and in the neurons continuously exposed to nicotine (0.1 microM).
Gene_expression (expression) of DBI mRNA in neurons associated with nicotine and withdrawal
15) Confidence 0.68 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11750077 Disease Relevance 0 Pain Relevance 0.57
When we examined brain from mice dependent on alcohol, nicotine, and morphine, we observed that the levels of DBI protein and its mRNA significantly increased.
Gene_expression (levels) of DBI protein in brain associated with nicotine, morphine and alcohol
16) Confidence 0.60 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.77 Pain Relevance 0.76
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Gene_expression (expression) of DBI in neurons associated with nicotine
17) Confidence 0.58 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.48
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Gene_expression (expression) of diazepam binding inhibitor in neurons associated with nicotine
18) Confidence 0.58 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.48
Therefore, these alterations in DBI expression have a close relationship with formation of drug dependence and/or emergence of withdrawal syndrome and are considered to be a common biochemical process in drug dependence induced by different drugs of abuse.
Gene_expression (expression) of DBI associated with drug dependence, addiction and withdrawal
19) Confidence 0.53 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11288485 Disease Relevance 0.84 Pain Relevance 0.83
These lines of data suggest that cerebral DBI expression in brain may participates in formation of drug dependence and/or emergence of withdrawal syndrome.
Gene_expression (expression) of DBI in brain associated with drug dependence, addiction and withdrawal
20) Confidence 0.53 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233989 Disease Relevance 0.90 Pain Relevance 0.76

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox