INT78676

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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 2.82
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
brain 1
nucleus 1
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.78 Very High Very High Very High
agonist 90 99.64 Very High Very High Very High
narcan 2 99.10 Very High Very High Very High
fluoxetine 10 99.02 Very High Very High Very High
sSRI 2 98.76 Very High Very High Very High
gABA 2 95.08 Very High Very High Very High
antidepressant 7 94.14 High High
depression 4 87.44 High High
withdrawal 5 84.68 Quite High
tolerance 2 83.32 Quite High
Disease Link Frequency Relevance Heat
Fatty Liver 504 95.56 Very High Very High Very High
Depression 4 87.44 High High
Insulin Resistance 200 87.36 High High
Liver Disease 144 77.44 Quite High
Dyslipidemia /

Combined Dyslipidemia

48 76.16 Quite High
Metabolic Syndrome 184 75.04 Quite High
Diabetes Mellitus 136 74.00 Quite High
INFLAMMATION 120 69.16 Quite High
Nash(non-alcoholic Steatohepatitis) 216 67.76 Quite High
Syndrome 16 67.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Continuous treatment with morphine increases diazepam binding inhibitor mRNA in mouse brain.
diazepam binding inhibitor Binding (binding) of in brain associated with narcan and morphine
1) Confidence 0.37 Published 1998 Journal J. Neurochem. Section Title Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.83
The antidepressant like effect of ethanol was potentiated by GABA(A) receptor agonist, muscimol (0.5 mg/kg, i.p.), 3alpha,5alpha-THP (0.5, 1 or 2 microg/mouse, i.c.v.) and by neurosteroidogenic drugs viz. selective serotonin reuptake inhibitor (SSRI), fluoxetine (5 or 20 mg/kg, i.p.), agonist at mitochondrial diazepam binding inhibitor receptor, FGIN 1-27 (0.5 or 1 microg/mouse, i.c.v.), or 11beta-hydroxylase inhibitor, metyrapone (0.5 or 1 microg/mouse, i.c.v.) which are known to increase endogenous 3alpha,5alpha-THP content.
diazepam binding inhibitor Binding (binding) of associated with gaba, antidepressant, agonist, ssri and fluoxetine
2) Confidence 0.36 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527484 Disease Relevance 0.09 Pain Relevance 0.85
In contrast, ACBP binds saturated LCFAs, which preferentially bind and activate HNF4?.
ACBP Binding (binds) of
3) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
is able to be activated by selective fatty acids through interaction with L-FABP or ACBP.
ACBP Binding (interaction) of
4) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.99 Pain Relevance 0
, while ACBP preferentially binds saturated LCFAs and associates with HNF4?
ACBP Binding (binds) of
5) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.46 Pain Relevance 0.03
FABP and ACBP bind a diverse array of fatty acids including eicosanoids [39] and facilitate intracellular transport of FA and FA-CoAs from the cytosol to different organelles including the nucleus.
ACBP Binding (bind) of in nucleus
6) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.40 Pain Relevance 0.03
/ACBP would mediate a differential association with coactivators and corepressors to their respective target genes to control fatty metabolism.
ACBP Binding (association) of
7) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
In addition, intracellular fatty acids produced from triglyceride hydrolysis or de novo lipogenesis (DNL) can regulate gene expression, suggesting that not only the type of fatty acids (saturated versus unsaturated), sources (intracellular versus exogenous), fatty acid association with different fatty acid transport proteins (L-FABP and ACBP), and type of fatty acid metabolites (FATP/ACSVL) have selective effects in regulating genes involved in oxidation, synthesis, and storage of fatty acids [10, 11].
ACBP Binding (association) of
8) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.41 Pain Relevance 0.07
In contrast, ACBP binds saturated LCFAs, which preferentially bind and activate HNF4?.
ACBP Binding (bind) of
9) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
through binding to acyl-CoA binding protein (ACBP) containing LCFA while SREBP-1c activation by LCFA occurs by recruiting SREBP-1c and PPAR?
acyl-CoA binding protein Binding (binding) of
10) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.41 Pain Relevance 0

General Comments

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