INT78694

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 18.64
Pain Relevance 19.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
livers 6
olfactory 4
spinal cord 2
brain 2
striatum 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 176 100.00 Very High Very High Very High
cocaine 62 100.00 Very High Very High Very High
Paracetamol 7 99.98 Very High Very High Very High
Clonidine 12 99.70 Very High Very High Very High
antagonist 43 99.40 Very High Very High Very High
Spinal cord 30 99.40 Very High Very High Very High
Lamotrigine 10 99.32 Very High Very High Very High
Acupuncture 8 99.18 Very High Very High Very High
Inflammation 156 99.08 Very High Very High Very High
nMDA receptor antagonist 10 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 850 100.00 Very High Very High Very High
INFLAMMATION 183 99.08 Very High Very High Very High
Cancer 292 98.24 Very High Very High Very High
Death 196 97.44 Very High Very High Very High
Disease 86 97.32 Very High Very High Very High
Body Weight 30 95.20 Very High Very High Very High
Drug Dependence 12 95.12 Very High Very High Very High
Cerebral Malaria 87 94.40 High High
Pancreatic Cancer 14 94.00 High High
Necrosis 35 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA also showed an regulatory effect on the increased the expression of CPP32 and decreased the expression of Bcl-2 by morphine.
Positive_regulation (increased) of Gene_expression (expression) of CPP32 associated with acupuncture and morphine
1) Confidence 0.66 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830972 Disease Relevance 0.31 Pain Relevance 1.06
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with cocaine and morphine
2) Confidence 0.61 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.38 Pain Relevance 0.83
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of caspase-3
3) Confidence 0.49 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
A 4-fold induction of keratinocyte apoptosis was observed in knockouts relative to WT animals, as documented by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling and caspase-3 staining.
Positive_regulation (documented) of Gene_expression (staining) of caspase-3 in keratinocyte associated with apoptosis
4) Confidence 0.49 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15313895 Disease Relevance 0.88 Pain Relevance 0.07
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Positive_regulation (activation) of Gene_expression (expression) of caspase-3 associated with qutenza, cancer and apoptosis
5) Confidence 0.49 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.78 Pain Relevance 0.88
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3 associated with qutenza, cancer and apoptosis
6) Confidence 0.49 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.78 Pain Relevance 0.88
RESULTS: The basal expression of cleaved caspase-3 in untreated tumours (23%) increased after cryotherapy.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3
7) Confidence 0.45 Published 2005 Journal Pathol. Biol. Section Body Doc Link 15850952 Disease Relevance 0 Pain Relevance 0
MPEP at 30, but not 10 mg/kg significantly inhibited the acquisition as well as expression of morphine-induced CPP, but it neither produced place preference or aversion, nor affected locomotor activity of mice.
Positive_regulation (morphine-induced) of Gene_expression (expression) of CPP associated with eae and morphine
8) Confidence 0.43 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527470 Disease Relevance 0 Pain Relevance 0.60
Moreover, the expression of CPP induced by 6 nmol morphine was also inhibited by NPS (0.1, 1 and 10 nmol).
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
9) Confidence 0.43 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0.05 Pain Relevance 1.15
In the present study the effects of an essential oil of Pimpinella anisum (Umbeliferae) on the expression and acquisition of conditioned place preference (CPP) induced by morphine in mice were investigated.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
10) Confidence 0.41 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 11891086 Disease Relevance 0.10 Pain Relevance 0.50
Acquisition and expression of morphine-induced CPP were reduced by lamotrigine at doses of 1, 5 and 25 mg kg(-1) and 5 and 25 mg kg(-1), respectively.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with lamotrigine and morphine
11) Confidence 0.41 Published 2009 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19579915 Disease Relevance 0 Pain Relevance 1.16
Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
12) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of CPP associated with morphine
13) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
In line with the TUNEL assay observation, our further results indicated that ethanol treatment significantly increased expression of the pro-apoptotic proteins Bax and Caspase-3 while decreasing the level of the anti-apoptotic protein Bcl-2.
Positive_regulation (increased) of Gene_expression (expression) of Caspase-3 associated with apoptosis
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.80 Pain Relevance 0
In the second set of experiments, the drugs were used before testing on Day 5, to test their effects on the expression of morphine-induced CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
15) Confidence 0.34 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.41
Intrapritoneal administration of phenylephrine and clonidine decreased the expression of morphine-induced CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine and clonidine
16) Confidence 0.34 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.43
In contrast, after application of prazosin or yohimbine, the expression of morphine-induced CPP was increased.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
17) Confidence 0.34 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.43
Several studies have shown that the systemic administration of a variety of N-methyl-D-aspartate (NMDA) receptor antagonists can block the development or expression of conditioned place preference (CPP) induced by rewarding drugs such as morphine.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with antagonist and morphine
18) Confidence 0.33 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.39
Expression levels of the active caspase-3 fragment were markedly increased in the lumbar spinal cord of hSOD1G93A mice, but caspase-3 expression was maintained at a very low level in the spinal cord of BV-treated hSOD1G93A mice.
Positive_regulation (increased) of Gene_expression (Expression) of caspase-3 in spinal cord associated with spinal cord
19) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.61 Pain Relevance 0.45
Expression of intracellular activated caspase 3 was analyzed using the caspase 3 active form from the monoclonal antibody apoptosis kit (1:50; BD Biosciences, Bedford, MA).
Positive_regulation (activated) of Spec (analyzed) Gene_expression (Expression) of caspase 3 associated with apoptosis
20) Confidence 0.30 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.10 Pain Relevance 0.03

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