INT78695

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 7
Speculated 6
Reported most in Abstract
Documents 24
Total Number 30
Disease Relevance 9.43
Pain Relevance 10.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
prefrontal 4
CPA 3
skeletal muscle 1
brain 1
uterine 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 88 100.00 Very High Very High Very High
Morphine 77 100.00 Very High Very High Very High
adenocard 1 100.00 Very High Very High Very High
Clonidine 12 99.76 Very High Very High Very High
Nucleus accumbens 14 99.12 Very High Very High Very High
opioid receptor 3 99.10 Very High Very High Very High
nMDA receptor antagonist 7 98.88 Very High Very High Very High
cva 24 98.52 Very High Very High Very High
Dopamine 86 98.28 Very High Very High Very High
antagonist 31 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 256 100.00 Very High Very High Very High
Cancer 271 99.68 Very High Very High Very High
Death 94 98.90 Very High Very High Very High
Cv General 3 Under Development 22 98.52 Very High Very High Very High
Pancreatic Cancer 90 98.50 Very High Very High Very High
Pre-term Labor 1 95.80 Very High Very High Very High
Malaria 66 94.00 High High
Necrosis 7 93.80 High High
Chronic Hepatitis 1 93.08 High High
Pneumonia 2 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Spec (analyse) Regulation (effects) of caspase-3 in brain associated with apoptosis
1) Confidence 0.44 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
In Experiment 1, we examined the effects of a single dose of cocaine and amphetamine on a previously extinguished morphine CPP.
Spec (examined) Regulation (effects) of CPP associated with morphine and cocaine
2) Confidence 0.39 Published 2005 Journal Behav Pharmacol Section Abstract Doc Link 15961965 Disease Relevance 0 Pain Relevance 0.66
Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time.
Regulation (depend) of CPP associated with morphine
3) Confidence 0.39 Published 2007 Journal Addict Biol Section Abstract Doc Link 17678506 Disease Relevance 0 Pain Relevance 0.88
In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3.
Regulation (regulation) of caspase 3 in uterine
4) Confidence 0.27 Published 2009 Journal Biol. Reprod. Section Abstract Doc Link 19144964 Disease Relevance 0.10 Pain Relevance 0
Caspase 3 assay and effect on DNA fragmentation
Regulation (effect) of Caspase 3
5) Confidence 0.24 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962271 Disease Relevance 1.05 Pain Relevance 0
Imipramine (0.5-2.5 mg/kg), phenylephrine (0.5-2 mg/kg), yohimbine (0.5-2 mg/kg) or prazosin (0.1-1 mg/kg) did not influence CPP, but clonidine (0.002-0.05 mg/kg) induced CPA.
Neg (not) Regulation (influence) of CPP in CPA associated with clonidine
6) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.13
Phenylephrine did not influence the CPP induced by morphine.
Neg (not) Regulation (influence) of CPP associated with morphine
7) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.28
RESULTS: (a) Either cocaine or morphine promoted significant CPP at lower doses in C57 than in DBA mice; (b) only drug-trained C57 mice showed a significant CPP compared with the control group; and (c) only C57 mice showed dose-dependent effects of cocaine on CPP.
Regulation (effects) of CPP
8) Confidence 0.24 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15864555 Disease Relevance 0 Pain Relevance 0
It is concluded that imipramine can induce CPA through an opioid receptor mechanism and alpha-adrenoceptor agents may influence morphine CPP.
Spec (may) Regulation (influence) of CPP in CPA associated with opioid receptor and morphine
9) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.11
Administration of Jo2 alone increased hepatic inducible nitric oxide synthase nitric oxide synthase but did not modify serum alanine aminotransferase (ALT), hepatic adenosine triphosphate (ATP), glutathione (GSH), cytochrome P-450, cytosolic cytochrome c, caspase-3 activity or hepatic morphology.
Neg (not) Regulation (modify) of caspase-3 associated with adenocard
10) Confidence 0.23 Published 2004 Journal Hepatology Section Abstract Doc Link 14999684 Disease Relevance 0.61 Pain Relevance 0.36
The role of the infralimbic cortex, on the other hand, is less clear as its involvement in the reinstatement of CPP has not been assessed.
Regulation (involvement) of CPP in cortex
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012115 Disease Relevance 0 Pain Relevance 0.33
Several key molecules, including caspase-3, Bcl-2, BAD and Bax, were modulated by l-THP treatment.
Regulation (modulated) of caspase-3
12) Confidence 0.15 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 20109541 Disease Relevance 0.34 Pain Relevance 0.09
It may be concluded that alpha-adrenoceptor mechanism(s) influence morphine-induced CPP in female mice.
Regulation (influence) of CPP associated with morphine
13) Confidence 0.13 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.14
Firstly, we studied the rewarding effects of both drugs on the CPP and the ability of MDMA to reinstate the extinguished preference.
Regulation (effects) of CPP
14) Confidence 0.11 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0 Pain Relevance 0.38
In a second series of experiments, we assessed the effects of selective prefrontal cortical NE depletion on conditioned place preference (CPP) and on conditioned place aversion (CPA) induced by rewarding and aversive natural stimuli respectively.
Regulation (effects) of CPP in prefrontal
15) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0 Pain Relevance 0
In contrast, blocking PI-3 kinase, p38 kinase and JNK activities by LY294002, SB20358 and SP600125 respectively abolished the phosphorylation of Akt-1, p38 kinase and JNK without affecting the levels of cleaved caspase-3 and -7 (Fig. 4A).
Regulation (affecting) of caspase-3
16) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.49 Pain Relevance 0
The MPP+ treatment induced the activation of caspase-3 in TSM1 neurons up to 233.9% as compared to the untreated control of active caspase-3 content of TSM1 cells.
Regulation (control) of caspase-3 in neurons
17) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0 Pain Relevance 0
dominant negative mutant each inhibited the anti-apoptotic effects of carbon monoxide through a pathway involving the modulation of caspase 3 [65].
Regulation (modulation) of caspase 3 associated with apoptosis
18) Confidence 0.09 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.06 Pain Relevance 0
Although anisomycin treatment resulted in an increase of caspase-3 levels of about 2.59-fold of control, GW501516 did not affect anisomycin-induced changes in active caspase-3 levels.
Regulation (changes) of caspase-3
19) Confidence 0.08 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2651001 Disease Relevance 0.33 Pain Relevance 0
Moreover and most importantly, in the present experiment the same depletion did not affect the performance of control animals in CPP or CPA induced by mildly salient stimuli.
Neg (not) Regulation (affect) of CPP in CPA
20) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0.16 Pain Relevance 0

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