INT78696

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Context Info
Confidence 0.39
First Reported 1998
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.93
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 65 100.00 Very High Very High Very High
nMDA receptor antagonist 7 98.88 Very High Very High Very High
Clonidine 9 97.28 Very High Very High Very High
antagonist 18 96.28 Very High Very High Very High
Eae 8 95.60 Very High Very High Very High
Cannabinoid 47 92.72 High High
agonist 31 91.76 High High
COX-2 inhibitor 1 91.04 High High
Potency 1 88.80 High High
aspirin 1 87.96 High High
Disease Link Frequency Relevance Heat
Apoptosis 48 99.84 Very High Very High Very High
Lung Cancer 13 99.54 Very High Very High Very High
Carcinoma 25 93.64 High High
Death 7 90.96 High High
Colon Cancer 25 88.04 High High
Morphine Dependence 2 79.48 Quite High
Opiate Addiction 3 76.00 Quite High
INFLAMMATION 2 75.00 Quite High
Malignant Neoplastic Disease 2 75.00 Quite High
Cancer 19 61.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time.
Regulation (depend) of Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.39 Published 2007 Journal Addict Biol Section Abstract Doc Link 17678506 Disease Relevance 0 Pain Relevance 0.88
Phenylephrine did not influence the CPP induced by morphine.
Neg (not) Regulation (influence) of Neg (not) Positive_regulation (induced) of CPP associated with morphine
2) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.28
This study revealed that coadministration of morphine and M6G induced CPP of similar magnitude to the sum of equimolar doses of these compounds alone, and different ratios of the two drugs did not affect the results.
Neg (not) Regulation (affect) of Positive_regulation (induced) of CPP associated with morphine
3) Confidence 0.17 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19351545 Disease Relevance 0 Pain Relevance 1.15
It may be concluded that alpha-adrenoceptor mechanism(s) influence morphine-induced CPP in female mice.
Regulation (influence) of Positive_regulation (induced) of CPP associated with morphine
4) Confidence 0.13 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.14
In the second set of experiments, the drugs were used before testing on Day 5, to test their effects on the expression of morphine-induced CPP.
Regulation (effects) of Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.13 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.41
Celecoxib, in a dose- and time-dependent manner, induced MM cell apoptosis, which involved decreased Akt phosphorylation, loss of Bcl-2 and Survivin protein expression and caspase-3 activation.
Regulation (involved) of Positive_regulation (activation) of caspase-3 associated with lung cancer and apoptosis
6) Confidence 0.09 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14961568 Disease Relevance 1.47 Pain Relevance 0.22
NMDA receptor antagonists given for 3 days after the end of conditioning did not influence the extinction of morphine-induced CPP.
Neg (not) Regulation (influence) of Positive_regulation (induced) of CPP associated with nmda receptor antagonist and morphine
7) Confidence 0.07 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9833632 Disease Relevance 0.30 Pain Relevance 1.47
Moreover, when this sub-threshold dose of MDMA was administered with 0.1 mg/kg of WIN, the CPP induced was not affected by blockade of the CB1 receptor.
Neg (not) Regulation (affected) of Positive_regulation (induced) of CPP
8) Confidence 0.05 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0 Pain Relevance 0.64
Caspase-3/7 activation in CXCL12 cells was sensitive to the broad-spectrum caspase-inhibitor zVAD, consistent with apoptosis (Figure 3A,C,E).
Regulation (sensitive) of Positive_regulation (activation) of Caspase-3 associated with apoptosis
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.17 Pain Relevance 0

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