INT78697

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 11.22
Pain Relevance 16.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
liver 8
HFL1 6
spinal cord 4
neurons 4
apoptotic cells 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 71 100.00 Very High Very High Very High
Paracetamol 40 100.00 Very High Very High Very High
cocaine 13 100.00 Very High Very High Very High
Clonidine 3 99.98 Very High Very High Very High
antagonist 45 99.90 Very High Very High Very High
Lamotrigine 10 99.84 Very High Very High Very High
nMDA receptor antagonist 13 99.68 Very High Very High Very High
imagery 8 99.64 Very High Very High Very High
Spinal cord 100 99.52 Very High Very High Very High
Sciatic nerve 3 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 68 100.00 Very High Very High Very High
Cancer 39 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Hypoxia 5 100.00 Very High Very High Very High
Nervous System Injury 7 99.56 Very High Very High Very High
Apoptosis 214 99.00 Very High Very High Very High
Injury 25 98.72 Very High Very High Very High
INFLAMMATION 102 98.68 Very High Very High Very High
Adhesions 3 98.04 Very High Very High Very High
Urological Neuroanatomy 6 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Negative_regulation (reduce) of Gene_expression (expression) of caspase-3 in liver associated with necrosis and hypoxia
1) Confidence 0.57 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.61 Pain Relevance 0.63
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Negative_regulation (blocked) of Gene_expression (expression) of CPP associated with cocaine and morphine
2) Confidence 0.51 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.38 Pain Relevance 0.84
Administration of Ro 64-6198 (0.3 or 1 mg/kg, i.p.) on the test day alone, in a separate group of animals, failed to block the expression of morphine CPP.
Negative_regulation (block) of Gene_expression (expression) of CPP associated with morphine
3) Confidence 0.51 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15919100 Disease Relevance 0.06 Pain Relevance 1.06
MPEP at 30, but not 10 mg/kg significantly inhibited the acquisition as well as expression of morphine-induced CPP, but it neither produced place preference or aversion, nor affected locomotor activity of mice.
Negative_regulation (inhibited) of Gene_expression (expression) of CPP associated with eae and morphine
4) Confidence 0.51 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527470 Disease Relevance 0 Pain Relevance 0.61
In contrast, while caspase-3 expression in neurons also declined with further distance from the injury, there was no effect of genotype.
Negative_regulation (declined) of Gene_expression (expression) of caspase-3 in neurons associated with injury
5) Confidence 0.43 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 1.04 Pain Relevance 0.39
Acquisition and expression of morphine-induced CPP were reduced by lamotrigine at doses of 1, 5 and 25 mg kg(-1) and 5 and 25 mg kg(-1), respectively.
Negative_regulation (reduced) of Gene_expression (expression) of CPP associated with lamotrigine and morphine
6) Confidence 0.38 Published 2009 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19579915 Disease Relevance 0 Pain Relevance 1.16
Conversely, the expression of caspase-3 was decreased by spared nerve injury of the sciatic nerve in the same brain area.
Negative_regulation (decreased) of Gene_expression (expression) of caspase-3 in nerve associated with nervous system injury and sciatic nerve
7) Confidence 0.32 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.71 Pain Relevance 0.78
Several studies have shown that the systemic administration of a variety of N-methyl-D-aspartate (NMDA) receptor antagonists can block the development or expression of conditioned place preference (CPP) induced by rewarding drugs such as morphine.
Negative_regulation (block) of Gene_expression (expression) of CPP associated with antagonist and morphine
8) Confidence 0.31 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.38
Intrapritoneal administration of phenylephrine and clonidine decreased the expression of morphine-induced CPP.
Negative_regulation (decreased) of Gene_expression (expression) of CPP associated with morphine and clonidine
9) Confidence 0.29 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.44
More specifically, caspase-3 expression was found to be reduced by 80% relative to the level observed in untreated hSOD1G93A mice (Figure 6A).
Negative_regulation (reduced) of Gene_expression (expression) of caspase-3
10) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.44 Pain Relevance 0.41
Moreover, the expression of CPP induced by 6 nmol morphine was also inhibited by NPS (0.1, 1 and 10 nmol).
Negative_regulation (inhibited) of Gene_expression (expression) of CPP associated with morphine
11) Confidence 0.26 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0.05 Pain Relevance 1.15
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Negative_regulation (suppressed) of Gene_expression (expression) of caspase-3 associated with death
12) Confidence 0.24 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.75 Pain Relevance 0.24
Cell death was assessed 72 h after OGD using propidium iodide labeling and protein expression of activated caspase 3.
Negative_regulation (using) of Gene_expression (expression) of caspase 3
13) Confidence 0.24 Published 2010 Journal Anesthesiology Section Body Doc Link 20098140 Disease Relevance 0.08 Pain Relevance 0
Furthermore, according to the results from Western blot analysis, ASE markedly decreased APAP-induced caspase-3 and -8 protein expressions in mouse livers.
Negative_regulation (decreased) of Gene_expression (expressions) of caspase-3 in livers associated with paracetamol
14) Confidence 0.23 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.51 Pain Relevance 0.60
Detection of Active Caspase-3—Immunohistochemical staining
of the active caspase-3 was performed with the active caspase-3-specific
antibody (Abcam, Cambridge, MA) on 5-?
Negative_regulation (Detection) of Gene_expression (staining) of Caspase-3
15) Confidence 0.23 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2570855 Disease Relevance 0.06 Pain Relevance 0.05
Detection of Active Caspase-3—Immunohistochemical staining
of the active caspase-3 was performed with the active caspase-3-specific
antibody (Abcam, Cambridge, MA) on 5-?
Negative_regulation (Detection) of Gene_expression (staining) of caspase-3
16) Confidence 0.23 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2570855 Disease Relevance 0.06 Pain Relevance 0.05
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Negative_regulation (decreased) of Gene_expression (activation) of caspase-3 in neuronal
17) Confidence 0.21 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.62 Pain Relevance 0.08
Expression levels of the active caspase-3 fragment were markedly increased in the lumbar spinal cord of hSOD1G93A mice, but caspase-3 expression was maintained at a very low level in the spinal cord of BV-treated hSOD1G93A mice.
Negative_regulation (maintained) of Gene_expression (expression) of caspase-3 in spinal cord associated with spinal cord
18) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.52 Pain Relevance 0.39
We found that the levels of active caspase-3 were significantly reduced in the lumbar spinal cord of hSOD1G93A mice following BV treatment (Figure 6A).
Negative_regulation (reduced) of Gene_expression (levels) of caspase-3 in spinal cord associated with spinal cord
19) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 1.00 Pain Relevance 0.45
expression of RGS and CC3 was lower in these cells as
Negative_regulation (lower) of Gene_expression (expression) of CC3
20) Confidence 0.20 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0

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