INT78702

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 12.94
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL11) extracellular space (CCL11) extracellular region (CCL11)
cell adhesion (CCL11) cytoskeleton organization (CCL11)
Anatomy Link Frequency
plasma 2
fibroblast 1
eosinophils 1
coronary artery 1
plaque 1
CCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 207 99.78 Very High Very High Very High
Inflammation 331 98.44 Very High Very High Very High
chemokine 74 98.44 Very High Very High Very High
cytokine 171 96.00 Very High Very High Very High
metalloproteinase 3 95.16 Very High Very High Very High
Crohn's disease 23 91.60 High High
cINOD 10 86.16 High High
Angina 6 79.60 Quite High
headache 3 76.48 Quite High
aspirin 17 75.00 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 204 99.78 Very High Very High Very High
Targeted Disruption 23 99.74 Very High Very High Very High
Pulmonary Disease 148 99.68 Very High Very High Very High
Hypersensitivity 49 99.40 Very High Very High Very High
Eosinophilic Esophagitis 424 99.28 Very High Very High Very High
Rhinitis 79 98.96 Very High Very High Very High
Disease 154 98.84 Very High Very High Very High
Chlamydia Infection 2 98.84 Very High Very High Very High
Gastroesophageal Reflux Disease 144 98.76 Very High Very High Very High
Infection 62 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, our data demonstrate that eotaxin concentrations are elevated independently from C-reactive protein in patients with coronary artery disease and correlate with antibodies against infectious agents known for chronic infection in humans.
Neg (independently) Positive_regulation (elevated) of eotaxin in coronary artery associated with coronary artery disease and infection
1) Confidence 0.68 Published 2006 Journal J. Investig. Med. Section Abstract Doc Link 17169268 Disease Relevance 0.98 Pain Relevance 0.20
We therefore sought to determine whether chronic infection with Chlamydia pneumoniae or other infectious agents is correlated with concentrations of eotaxin or C-reactive protein since this mechanism could explain the finding that chronic infection stimulates smooth muscle cell migration and plaque development.
Positive_regulation (concentrations) of eotaxin in plaque associated with chlamydia infection and infection
2) Confidence 0.49 Published 2006 Journal J. Investig. Med. Section Abstract Doc Link 17169268 Disease Relevance 0.81 Pain Relevance 0.08
Pretreatment of (111)In-labeled eosinophils in vitro with F(ab')2 2A8 selectively inhibited their accumulation in response to eotaxin in vivo.
Positive_regulation (accumulation) of eotaxin in eosinophils
3) Confidence 0.45 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9834099 Disease Relevance 0.11 Pain Relevance 0.27
In our previous analysis on a subset of patients and parents with FMS, we found elevation of MCP-1 and eotaxin plasma levels [18], but the standard deviation on IL-1?
Positive_regulation (elevation) of eotaxin in plasma associated with fibrositis
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.78 Pain Relevance 0.42
As shown in Figure 2, MCP-1, IP-10 and eotaxin plasma levels were elevated, on average, for all FMS patients vs. unrelated controls, except those with the rare alleles for the MEFV gene, who were empirically intermediate, but cannot be statistically distinguished from either controls or other FMS patients.
Positive_regulation (elevated) of eotaxin in plasma associated with fibrositis
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.55 Pain Relevance 0.44
Immunoglobulin and eotaxin receptors were also found to be upregulated.
Positive_regulation (upregulated) of eotaxin
6) Confidence 0.45 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.47 Pain Relevance 0
Patients (56/92) treated with the single agent guaifenesin (>3 months) had higher levels of eotaxin than those not treated (P<0.01).
Positive_regulation (levels) of eotaxin
7) Confidence 0.45 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.10 Pain Relevance 0.65
In contrast to naturally occurring CCL11, NNY-CCL14 is resistant to degradation by CD26/dipeptidyl peptidase IV (DP4).
Positive_regulation (occurring) of CCL11
8) Confidence 0.24 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.27 Pain Relevance 0.10
Increased lumen levels of CCL11 have been associated with acute loss of mucosal eosinophils into the tracheal lumen in allergen-challenged guinea-pigs [115].
Positive_regulation (Increased) of CCL11 in lumen
9) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.10 Pain Relevance 0.09
The eosinophil attracting chemokines “Regulated upon Activation, Normal T-cell Expressed, and Secreted” (RANTES), eotaxin, and interleukin-5 (IL-5) have been reported to be increased during COPD exacerbations (Zhu et al 2001; Bocchino et al 2002; Rohde et al 2004; Fujimoto et al 2005).
Positive_regulation (increased) of eotaxin in T-cell associated with chemokine and pulmonary disease
10) Confidence 0.20 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.20 Pain Relevance 0.20
The extent of the increases in ERK was correlated with bFGF increases in expression (R = 0.89, p < 0.05) (Figure 2a) and with eotaxin increases in expression (R= 0.82, p < 0.05) (Figure 2b).
Positive_regulation (increases) of eotaxin
11) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.04 Pain Relevance 0
Along with bFGF upregulation, an increase in eotaxin was also seen in EoE subjects.
Positive_regulation (increase) of eotaxin associated with eosinophilic esophagitis
12) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.99 Pain Relevance 0
EoE subjects had a slight but not statistically significant increase in eotaxin-3 expression when compared to GERD (2×, p > 0.05) and to HC (6×, p > 0.05) (Figure 1b).
Neg (not) Positive_regulation (increase) of eotaxin associated with gastroesophageal reflux disease and eosinophilic esophagitis
13) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.06 Pain Relevance 0
Of the transcripts tested for possible immune indicators, we found extracellular signal-regulated kinase (ERK), Bcl-2, bFGF (basic fibroblast growth factor), and eotaxin levels were highly upregulated in PBMC and associated with disease presence of EoE.
Positive_regulation (upregulated) of eotaxin in fibroblast associated with disease and eosinophilic esophagitis
14) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Abstract Doc Link PMC2976489 Disease Relevance 1.72 Pain Relevance 0.07
IL-13 is reported to induce eosinophil recruitment into the lung via an IL-5- and eotaxin-dependent mechanism.30 Indeed, several studies have reported that IL-13 induces eotaxin production in epithelial and smooth muscle cells.31,32 In-vivo data have shown that IL-13 stimulates eotaxin in IL-13 transgenic mice.33 The increase in eotaxin-1 levels was proportional to the impaired lung function and bronchial hyper-reactivity in asthmatics, as shown in previous studies.34,35 In this study, we found that the GG genotype of the Arg110Gln (110G>A) polymorphism was associated with a significantly higher eotaxin-1 level, as compared to the AA type; these findings suggest that the 110G allele is associated with eotaxin-1-mediated eosinophilic inflammation.
Positive_regulation (increase) of eotaxin-1 in lung associated with targeted disruption, rhinitis, inflammation and occupational lung diseases
15) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.74 Pain Relevance 0.04
IL-13 Arg110Gln may be associated with an increased eosinophil count and eotaxin-1 level and could increase eosinophilic inflammation in the upper and lower airways of patients with AIA.



Positive_regulation (increased) of eotaxin-1 in upper associated with asthma, rhinitis and inflammation
16) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2846737 Disease Relevance 1.00 Pain Relevance 0.16

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