INT78713

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 7.07
Pain Relevance 6.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
Nerve 3
dentate gyrus 2
sensory neurons 1
bladder 1
primary sensory neurons 1
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
neuralgia 9 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Etanercept 1 99.96 Very High Very High Very High
Hyperalgesia 8 99.82 Very High Very High Very High
Nerve growth factor 14 99.48 Very High Very High Very High
Neuropathic pain 13 98.92 Very High Very High Very High
intrathecal 4 98.78 Very High Very High Very High
Adalimumab 1 98.40 Very High Very High Very High
Hippocampus 4 97.98 Very High Very High Very High
Infliximab 1 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 17 99.82 Very High Very High Very High
Injury 3 99.52 Very High Very High Very High
Neuropathic Pain 13 98.92 Very High Very High Very High
Neurodegenerative Disease 8 98.04 Very High Very High Very High
Rheumatoid Arthritis 2 97.72 Very High Very High Very High
Death 4 97.66 Very High Very High Very High
Nervous System Injury 12 97.60 Very High Very High Very High
Seronegative Spondarthritis 1 96.72 Very High Very High Very High
Inflammatory Pain 2 96.60 Very High Very High Very High
Bladder Cancer 2 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional inhibition of p75NTR suppressed injury-induced neuropathic pain and decreased the phosphorylation of TrkA and p38 mitogen-activated protein kinase, and the induction of transient receptor potential channels in dorsal root ganglion (DRG) neurons.
Negative_regulation (inhibition) of p75NTR in DRG associated with ganglion cysts, dorsal root ganglion, trp channel, injury and neuropathic pain
1) Confidence 0.54 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 0.98 Pain Relevance 0.60
Using a quick and sensitive flow cytometry method that can assess changes in the number of bromodeoxyuridine (BrdU)-positive cells in hippocampus, in combination with traditional histological cell counts in the dentate gyrus, we report that mice lacking the p75 neurotrophin receptor gene (p75(NTR-/-)) have significantly reduced hippocampal neurogenesis.
Negative_regulation (lacking) of p75 in dentate gyrus associated with hippocampus and neurodegenerative disease
2) Confidence 0.43 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 19621217 Disease Relevance 0.26 Pain Relevance 0.42
Using a quick and sensitive flow cytometry method that can assess changes in the number of bromodeoxyuridine (BrdU)-positive cells in hippocampus, in combination with traditional histological cell counts in the dentate gyrus, we report that mice lacking the p75 neurotrophin receptor gene (p75(NTR-/-)) have significantly reduced hippocampal neurogenesis.
Negative_regulation (lacking) of p75 in dentate gyrus associated with hippocampus and neurodegenerative disease
3) Confidence 0.43 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 19621217 Disease Relevance 0.25 Pain Relevance 0.41
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
Negative_regulation (Suppression) of p75 neurotrophin receptor in sensory neurons associated with neuralgia, nervous system injury and neuropathic pain
4) Confidence 0.40 Published 2006 Journal J. Neurosci. Section Title Doc Link 17108171 Disease Relevance 0.90 Pain Relevance 0.83
Here, we report that the pharmacological blockade of p75NTR in primary sensory neurons reversed neuropathic pain after nerve injury.
Negative_regulation (blockade) of p75NTR in primary sensory neurons associated with nervous system injury and neuropathic pain
5) Confidence 0.35 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 0.91 Pain Relevance 0.53
Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75.
Negative_regulation (lacking) of p75 in Nerve associated with hyperalgesia and nerve growth factor
6) Confidence 0.33 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9835221 Disease Relevance 0.68 Pain Relevance 0.86
Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75.
Negative_regulation (lacking) of neurotrophin receptor in Nerve associated with hyperalgesia and nerve growth factor
7) Confidence 0.33 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9835221 Disease Relevance 0.68 Pain Relevance 0.85
To examine a mechanistic relationship between ibuprofen induction of p75NTR protein and inhibition of survival, bladder cancer cells were transfected with ponasterone A-inducible vectors that expressed a death domain-deleted (DeltaDD) or intracellular domain-deleted (DeltaICD) p75NTR product that acts as a dominant negative antagonist of the intact p75NTR protein.
Negative_regulation (antagonist) of p75NTR in bladder associated with antagonist, bladder cancer and death
8) Confidence 0.20 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.67 Pain Relevance 0.73
Furthermore, thermal hyperalgesia induced by nerve ligation was completely suppressed by repeated intrathecal injection of a specific antibody to full-length TrkB and an inhibitor of the protein tyrosine kinase activity for the neurotrophin receptor, K-252a.
Negative_regulation (inhibitor) of neurotrophin receptor in nerve associated with thermal hyperalgesia and intrathecal
9) Confidence 0.12 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470870 Disease Relevance 0.55 Pain Relevance 0.89
Despite their specificity for TNF, these agents, which include the soluble p75 receptor etanercept and the anti-TNF antibodies adalimumab and infliximab, have demonstrated differential clinical efficacy in studies of rheumatoid arthritis; patients who do not respond to one antagonist often respond to another.
Negative_regulation (include) of p75 receptor associated with infliximab, antagonist, rheumatoid arthritis, adalimumab and etanercept
10) Confidence 0.01 Published 2007 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 17396108 Disease Relevance 1.19 Pain Relevance 0.60

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