INT7872

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 1
Speculated 8
Reported most in Abstract
Documents 74
Total Number 81
Disease Relevance 18.54
Pain Relevance 66.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medulla 13
pons 13
spinal cord 9
midbrain 6
forebrain 5
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 99 99.90 Very High Very High Very High
Morphine 117 99.84 Very High Very High Very High
narcan 32 99.84 Very High Very High Very High
agonist 153 99.82 Very High Very High Very High
opioid receptor 293 99.80 Very High Very High Very High
orphanin 18 99.80 Very High Very High Very High
Antinociceptive 42 99.78 Very High Very High Very High
dopamine receptor 7 99.78 Very High Very High Very High
Enkephalin 58 99.76 Very High Very High Very High
Endogenous opioid 10 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 81 99.36 Very High Very High Very High
Nociception 10 99.32 Very High Very High Very High
Neuropathic Pain 26 99.08 Very High Very High Very High
Targeted Disruption 94 98.96 Very High Very High Very High
Nervous System Injury 4 98.68 Very High Very High Very High
Bordatella Infection 5 98.00 Very High Very High Very High
Pain 10 97.88 Very High Very High Very High
Age-related Macular Degeneration 2 96.96 Very High Very High Very High
INFLAMMATION 4 96.16 Very High Very High Very High
Sprains And Strains 13 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increase in the G-protein activation induced by M-6-G was eliminated in sciatic nerve ligation.
Positive_regulation (activation) of G-protein in sciatic nerve associated with sciatic nerve
1) Confidence 0.50 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17593930 Disease Relevance 0.43 Pain Relevance 2.83
Furthermore, exposure to bisphenol-A during either organogenesis or lactation also produced an up-regulation of dopamine receptor function to activate G-protein in the mouse limbic forebrain.
Positive_regulation (activate) of G-protein in forebrain associated with dopamine receptor
2) Confidence 0.50 Published 2007 Journal Addict Biol Section Abstract Doc Link 17508988 Disease Relevance 0.16 Pain Relevance 0.22
Additionally, the treatment with bisphenol-A produced an up-regulation of dopamine receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for hyperlocomotion and rewarding effects by drugs of abuse.
Positive_regulation (activate) of G-protein in forebrain associated with dopamine receptor
3) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16678967 Disease Relevance 0.07 Pain Relevance 0.42
Furthermore, the reduction in G-protein activation induced by M-6-G may, at least in part, contribute to the suppression of the antinociceptive effect produced by morphine under a neuropathic pain-like state.
Positive_regulation (activation) of G-protein associated with neuropathic pain, antinociceptive and morphine
4) Confidence 0.43 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17593930 Disease Relevance 0.41 Pain Relevance 2.08
Hyperglycemic NOD mice were hyporesponsive to intracerebroventricular (i.c.v.) injections of [D-Ala(2)]deltorphin II but not to [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO); however, G-protein activation in pons/medulla assessed by [35S]GTPgammaS binding was not diminished.
Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, enkephalin and intracerebroventricular
5) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936496 Disease Relevance 0.86 Pain Relevance 0.69
Decreased opioid-induced antinociception but unaltered G-protein activation in the genetic-diabetic NOD mouse.
Positive_regulation (activation) of G-protein associated with antinociception, diabetes mellitus, nociceptor and opioid
6) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10936496 Disease Relevance 0.87 Pain Relevance 0.87
Furthermore, the exposure to bisphenol-A during either organogenesis or lactation also produced an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain.
Positive_regulation (activate) of G-protein in forebrain associated with dopamine
7) Confidence 0.38 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.23 Pain Relevance 0.26
Additionally, this treatment with bisphenol-A produced a down-regulation of dopamine D3 receptor and an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for rewarding effects by drugs of abuse.
Positive_regulation (activate) of G-protein in forebrain associated with dopamine
8) Confidence 0.38 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.17 Pain Relevance 0.24
Intermittent morphine treatment results in the upregulation of dopamine receptor-regulated G-protein activation in the mouse limbic forebrain, whereas this treatment causes the downregulation of GABA(B) receptor function to activate G-protein in the mouse lower midbrain.
Positive_regulation (activate) of G-protein in midbrain associated with gaba, dopamine receptor, midbrain and morphine
9) Confidence 0.31 Published 2003 Journal Addict Biol Section Abstract Doc Link 13129834 Disease Relevance 0 Pain Relevance 0.98
Intermittent morphine treatment results in the upregulation of dopamine receptor-regulated G-protein activation in the mouse limbic forebrain, whereas this treatment causes the downregulation of GABA(B) receptor function to activate G-protein in the mouse lower midbrain.
Positive_regulation (activation) of G-protein in midbrain associated with gaba, dopamine receptor, midbrain and morphine
10) Confidence 0.29 Published 2003 Journal Addict Biol Section Abstract Doc Link 13129834 Disease Relevance 0 Pain Relevance 0.94
In the mu-opioid receptor (MOR) binding study and G-protein activation, we confirmed that both morphine and oxycodone showed MOR agonistic activities.
Positive_regulation (activation) of G-protein associated with oxycodone, opioid receptor and morphine
11) Confidence 0.29 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17593930 Disease Relevance 0.26 Pain Relevance 1.74
G-protein activation was followed by a sequence of intracellular events, resulting in exocytosis.
Positive_regulation (activation) of G-protein
12) Confidence 0.24 Published 1992 Journal Cell Tissue Res. Section Abstract Doc Link 1358451 Disease Relevance 0 Pain Relevance 0.17
The present study was designed to investigate in streptozotocin-induced diabetic mice the effect of the selective micro-opioid agonist [D-Ala(2), NMePhe(4), Gly-ol(5)]enkephalin (DAMGO) on G-protein activation by monitoring guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to pons/medulla membranes, which contain the key areas for opioid antinociception.
Positive_regulation (activation) of G-protein in medulla associated with antinociception, medulla, mu agonist, diabetes mellitus, enkephalin and opioid
13) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.96 Pain Relevance 0.92
The present results indicated that the antinociceptive effect of DAMGO given supraspinally was less potent in streptozotocin-induced diabetic mice than that in non-diabetic mice, whereas the mu-opioid receptor-mediated G-protein activation in pons/medulla was unaltered in streptozotocin-induced diabetic mice.
Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, opioid receptor and antinociceptive
14) Confidence 0.17 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.90 Pain Relevance 0.72
The aim of the present study was to investigate whether repeated treatment with the mu-opioid receptor antagonist naloxone could affect G-protein activation induced by a selective mu-opioid receptor agonist [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) in mice lacking the protein kinase Cgamma isoform monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
Positive_regulation (activation) of G-protein associated with antagonist, agonist, narcan, enkephalin and opioid receptor
15) Confidence 0.17 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566163 Disease Relevance 0.07 Pain Relevance 0.55
However, no activation of the efficacy of D2 receptor coupling to G-protein could be measured in these and other brain regions.
Neg (no) Positive_regulation (activation) of G-protein in brain
16) Confidence 0.16 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 18406571 Disease Relevance 0.22 Pain Relevance 0.76
The partial agonistic properties of endogenous mu-opioid peptides endomorphin-1 and endomorphin-2 for G-protein activation were determined in the mouse spinal cord, monitoring the increases in guanosine-5'-o-(3-[35S]thio)triphosphate binding.
Positive_regulation (activation) of G-protein in spinal cord associated with opioid and spinal cord
17) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524159 Disease Relevance 0 Pain Relevance 0.42
Hyperglycemic NOD mice were hyporesponsive to intracerebroventricular (i.c.v.) injections of [D-Ala(2)]deltorphin II but not to [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO); however, G-protein activation in pons/medulla assessed by [35S]GTPgammaS binding was not diminished.
Positive_regulation (activation) of G-protein in pons associated with medulla, diabetes mellitus, enkephalin and intracerebroventricular
18) Confidence 0.14 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936496 Disease Relevance 0.86 Pain Relevance 0.69
The effect of ethanol on agonist stimulation of G-protein coupling was examined using [35S]GTPgammaS (guanosine-5'-O-(3-thio)triphosphate) binding to membranes.
Positive_regulation (stimulation) of G-protein
19) Confidence 0.14 Published 2000 Journal Anesthesiology Section Body Doc Link 10839931 Disease Relevance 0 Pain Relevance 0
The aim of this study was to evaluate the acute effects of clinically relevant concentrations of ethanol (50-200 mm) on the saturation binding kinetics, receptor/ligand internalization, and agonist stimulation of G-protein coupling in N18TG2 cells expressing the Flag epitope-tagged mouse DOR.
Positive_regulation (stimulation) of G-protein in N18TG2 associated with agonist
20) Confidence 0.14 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10839931 Disease Relevance 0 Pain Relevance 0.17

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