INT78728

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 6.89
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
monocytes 6
neutrophils 6
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 19 99.98 Very High Very High Very High
qutenza 15 99.98 Very High Very High Very High
narcan 12 99.82 Very High Very High Very High
dexamethasone 6 99.36 Very High Very High Very High
cINOD 21 97.44 Very High Very High Very High
Inflammatory mediators 8 93.88 High High
cytokine 20 92.64 High High
Analgesic 3 89.92 High High
rheumatoid arthritis 30 88.36 High High
Etanercept 1 87.56 High High
Disease Link Frequency Relevance Heat
Cancer 20 98.34 Very High Very High Very High
Leukemia 6 97.20 Very High Very High Very High
Necrosis 10 97.18 Very High Very High Very High
Apoptosis 5 96.58 Very High Very High Very High
INFLAMMATION 22 96.00 Very High Very High Very High
Endometriosis 10 95.04 Very High Very High Very High
Adhesions 6 92.12 High High
Pancreatic Cancer 15 92.00 High High
Rheumatoid Arthritis 30 88.36 High High
Sleep Initiation And Maintenance Disorders 2 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, decreased NF-kappa B DNA binding and transcriptional activities were detected in cells treated with the combination compared with the single agents, demonstrating cooperative targeting of the NF-kappa B pathway.
Negative_regulation (decreased) of NF-kappa B Binding (binding) of
1) Confidence 0.58 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.49 Pain Relevance 0.37
Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism.
Negative_regulation (inhibits) of NF-kappaB Binding (binding) of in neutrophils associated with morphine
2) Confidence 0.57 Published 2000 Journal Anesthesiology Section Title Doc Link 10839919 Disease Relevance 0.19 Pain Relevance 0.37
CONCLUSION: Morphine causes immunosuppression, at least in part, via the NO-stimulated depression of NF-kappaB nuclear binding.


Negative_regulation (depression) of NF-kappaB Binding (binding) of
3) Confidence 0.57 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
The NO synthase inhibitors Nomega-nitro-l-arginine-methyl-esther and Nomega-nitro-l-arginine completely abolished the morphine-induced attenuation of NF-kappaB nuclear binding, demonstrating that the inhibitory action is mediated by NO release.
Negative_regulation (abolished) of NF-kappaB Binding (binding) of
4) Confidence 0.57 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
Parthenolide treatment also dose-dependently increased the amount of the NF-kappa B inhibitory protein, I kappa B-alpha, and decreased NF-kappa B DNA binding activity.
Negative_regulation (decreased) of NF-kappa B Binding (activity) of
5) Confidence 0.43 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.52 Pain Relevance 0.35
Parthenolide treatment also dose-dependently increased the amount of the NF-kappa B inhibitory protein, I kappa B-alpha, and decreased NF-kappa B DNA binding activity.
Negative_regulation (decreased) of NF-kappa B Binding (binding) of
6) Confidence 0.43 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.52 Pain Relevance 0.34
In the electrophoretic mobility shift assay, dexamethasone and rofecoxib dose-dependently inhibited the DNA binding activity of NF-kappaB in stimulated monocytes, whereas indomethacin failed to inhibit the LPS-evoked one.
Negative_regulation (inhibited) of NF-kappaB Binding (binding) of in monocytes associated with dexamethasone
7) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.47
In the electrophoretic mobility shift assay, dexamethasone and rofecoxib dose-dependently inhibited the DNA binding activity of NF-kappaB in stimulated monocytes, whereas indomethacin failed to inhibit the LPS-evoked one.
Negative_regulation (inhibited) of NF-kappaB Binding (activity) of in monocytes associated with dexamethasone
8) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.47
As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity.
Negative_regulation (reduction) of NF-kappaB Binding (activity) of associated with necrosis, cancer, apoptosis and morphine
9) Confidence 0.42 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9837747 Disease Relevance 0.63 Pain Relevance 0.77
RESULTS: Morphine inhibits lipopolysaccharide-induced NF-kappaB nuclear binding in human blood neutrophils and monocytes in a time-, concentration-, and naloxone-sensitive-dependent manner.
Negative_regulation (inhibits) of NF-kappaB Binding (binding) of in neutrophils
10) Confidence 0.42 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
Electrophoretic mobility shift assay revealed that treatment of these cultures with the urinary preparation hCG-A suppressed TNF-alpha- or IL-1beta-induced NF-kappaB DNA-binding activity, whereas another urinary hCG preparation (hCG-B) was less effective.
Negative_regulation (suppressed) of NF-kappaB Binding (activity) of
11) Confidence 0.40 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.72 Pain Relevance 0.28
Electrophoretic mobility shift assay revealed that treatment of these cultures with the urinary preparation hCG-A suppressed TNF-alpha- or IL-1beta-induced NF-kappaB DNA-binding activity, whereas another urinary hCG preparation (hCG-B) was less effective.
Negative_regulation (suppressed) of NF-kappaB Binding (binding) of
12) Confidence 0.40 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.72 Pain Relevance 0.28
Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.
Negative_regulation (inhibit) of NF-kappaB Binding (binding) of associated with qutenza
13) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.34 Pain Relevance 0.10
Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding.
Negative_regulation (effect) of NF-kappaB Binding (binding) of associated with qutenza
14) Confidence 0.34 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.48 Pain Relevance 0.53
Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding.
Negative_regulation (abolished) of NF-kappaB Binding (binding) of associated with qutenza
15) Confidence 0.34 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.49 Pain Relevance 0.54
In addition, the -857T (but not the -857C) allele strongly binds the transcription factor OCT1, which blocks the interaction of nuclear factor-kappa-B (NF-?
Negative_regulation (blocks) of nuclear factor-kappa-B Binding (interaction) of
16) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906815 Disease Relevance 0.29 Pain Relevance 0.16
Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism.
Negative_regulation (inhibits) of NF-kappaB in monocytes Binding (binding) of in neutrophils associated with morphine
17) Confidence 0.19 Published 2000 Journal Anesthesiology Section Title Doc Link 10839919 Disease Relevance 0.19 Pain Relevance 0.37
RESULTS: Morphine inhibits lipopolysaccharide-induced NF-kappaB nuclear binding in human blood neutrophils and monocytes in a time-, concentration-, and naloxone-sensitive-dependent manner.
Negative_regulation (inhibits) of NF-kappaB in monocytes Binding (binding) of in neutrophils
18) Confidence 0.14 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox