INT7873

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1981
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 0.72
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b)
Anatomy Link Frequency
liver 9
fat 2
Ugt2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 70 100.00 Very High Very High Very High
Paracetamol 18 99.88 Very High Very High Very High
carbamazepine 3 98.24 Very High Very High Very High
diclofenac 3 94.96 High High
dexamethasone 2 77.04 Quite High
Bile 2 66.16 Quite High
cINOD 2 64.80 Quite High
Central nervous system 9 23.16 Low Low
medulla 1 20.64 Low Low
agonist 8 16.64 Low Low
Disease Link Frequency Relevance Heat
Stress 7 94.40 High High
Sprains And Strains 3 93.56 High High
Body Weight 8 80.88 Quite High
Injury 2 66.04 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 65.48 Quite High
INFLAMMATION 2 64.08 Quite High
Apoptosis 1 36.40 Quite Low
Reprotox - General 3 16 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Reprotox - General 1 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corn oil and olive oil diets caused 2-fold increases in the amount of UDP-glucuronosyltransferase versus the fat-free diet.
Positive_regulation (increases) of UDP-glucuronosyltransferase in fat
1) Confidence 0.70 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642647 Disease Relevance 0.06 Pain Relevance 0.12
Treatment with fish oil resulted in a 3-fold increase in the amount of UDP-glucuronosyltransferase versus the fat-free diet.
Positive_regulation (increase) of UDP-glucuronosyltransferase in fat
2) Confidence 0.70 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642647 Disease Relevance 0.07 Pain Relevance 0.13
These observations are in agreement with differential induction of UDP-glucuronosyltransferase activities in vitro suggesting that, besides other factors such as cofactor supply, physiological activators, etc., the levels of the multiple enzyme forms are critically determining glucuronide formation in the intact cell.
Positive_regulation (induction) of UDP-glucuronosyltransferase
3) Confidence 0.69 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6422942 Disease Relevance 0 Pain Relevance 0.07
Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3'-azido-3'-deoxythymidine: characterization of the enzyme in human and rat liver microsomes.
Positive_regulation (inducible) of UDP-glucuronosyltransferase in liver
4) Confidence 0.62 Published 1990 Journal Arch. Biochem. Biophys. Section Title Doc Link 2118332 Disease Relevance 0.07 Pain Relevance 0.12
Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alpha-carbonitrile.
Positive_regulation (Induction) of UDP-glucuronosyltransferase in livers
5) Confidence 0.60 Published 1982 Journal Drug Metab. Dispos. Section Title Doc Link 6130905 Disease Relevance 0 Pain Relevance 0.07
A third compound, diphenyl-4-pyridylmethane, induced UDP-glucuronosyltransferase (1-naphthol) activity without increasing ethoxyresorufin deethylase activity.
Positive_regulation (induced) of UDP-glucuronosyltransferase
6) Confidence 0.58 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8363642 Disease Relevance 0 Pain Relevance 0.07
Induction of UDP-glucuronosyltransferase (morphine) activity was seen with twelve of the eighteen compounds investigated, and for three compounds it occurred independent of any induction of cytochrome P450.
Positive_regulation (Induction) of UDP-glucuronosyltransferase associated with morphine
7) Confidence 0.58 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8363642 Disease Relevance 0 Pain Relevance 0.10
UDP-glucuronosyltransferase (1-naphthol) activity was coinduced by these two compounds.
Positive_regulation (coinduced) of UDP-glucuronosyltransferase
8) Confidence 0.58 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8363642 Disease Relevance 0 Pain Relevance 0.08
Acridine treatment increased UDP-glucuronosyltransferase activity toward morphine (47%), 1-naphthol (28%), testosterone (19%), and estrone (19%).
Positive_regulation (increased) of UDP-glucuronosyltransferase associated with morphine
9) Confidence 0.55 Published 1996 Journal J. Biochem. Toxicol. Section Abstract Doc Link 9176741 Disease Relevance 0 Pain Relevance 0.24
Exposure to 30 mM BSO in drinking water for 7 days induced hepatic microsomal UDP-glucuronosyltransferase activity (detergent-activated) toward p-nitrophenol (250%), 1-naphthol (210%), morphine (130%) and testosterone (140%), but not estrone.
Positive_regulation (induced) of UDP-glucuronosyltransferase associated with morphine
10) Confidence 0.55 Published 1990 Journal Toxicology Section Abstract Doc Link 2125759 Disease Relevance 0 Pain Relevance 0.10
Induction of rat UDP-glucuronosyltransferase and glutathione S-transferase activities by L-buthionine-S,R-sulfoximine without induction of cytochrome P-450.
Positive_regulation (Induction) of UDP-glucuronosyltransferase
11) Confidence 0.55 Published 1990 Journal Toxicology Section Title Doc Link 2125759 Disease Relevance 0.06 Pain Relevance 0.14
The detergent-activated UDP-glucuronosyltransferase activities towards morphine, 4-nitrophenol, and 1-naphthol were increased up to five-, three- and two-fold of control respectively.
Positive_regulation (increased) of UDP-glucuronosyltransferase associated with morphine
12) Confidence 0.55 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8498089 Disease Relevance 0 Pain Relevance 0.10
Significant increases in UDP-glucuronosyltransferase and glutathione S-transferase activities were also observed following 3 days of exposure to BSO in the drinking water at a concentration as low as 5 mM.
Positive_regulation (increases) of UDP-glucuronosyltransferase
13) Confidence 0.55 Published 1990 Journal Toxicology Section Abstract Doc Link 2125759 Disease Relevance 0.08 Pain Relevance 0.15
Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase.
Positive_regulation (induction) of UDP-glucuronosyltransferase in liver
14) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7906730 Disease Relevance 0 Pain Relevance 0
These results indicated that strychnine and brucine cause phenobarbital-like induction of the P450 enzyme, but show a different profile from phenobarbital in the induction of UDP-glucuronosyltransferase.
Positive_regulation (induction) of UDP-glucuronosyltransferase
15) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7906730 Disease Relevance 0 Pain Relevance 0.09
Concomitant induction of microsomal epoxide hydrolase and UDP-glucuronosyltransferase activities by dipyridine compounds.
Positive_regulation (induction) of UDP-glucuronosyltransferase
16) Confidence 0.50 Published 1992 Journal Drug Metab. Dispos. Section Title Doc Link 1358578 Disease Relevance 0 Pain Relevance 0.07
Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation: production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1.
Positive_regulation (Induction) of UDP-glucuronosyltransferase associated with morphine
17) Confidence 0.49 Published 1997 Journal Drug Metab. Dispos. Section Title Doc Link 9029046 Disease Relevance 0 Pain Relevance 0.62
Activation of morphine-UDP-glucuronosyltransferase (morphine-UDPGT) by Triton X-100 was more complex than that shown by Brij 58.
Positive_regulation (Activation) of morphine-UDP-glucuronosyltransferase associated with morphine
18) Confidence 0.42 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1768286 Disease Relevance 0 Pain Relevance 0.68
The detergent-activated UDP-glucuronosyltransferase activities towards morphine, 4-nitrophenol, and 1-naphthol were increased up to five-, three- and two-fold of control respectively.
Positive_regulation (detergent-activated) of UDP-glucuronosyltransferase associated with morphine
19) Confidence 0.40 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8498089 Disease Relevance 0 Pain Relevance 0.10
Quinacrine failed to elevate any UDP-glucuronosyltransferase activity and depressed activities toward testosterone and estrone by 20%.
Neg (failed) Positive_regulation (elevate) of UDP-glucuronosyltransferase
20) Confidence 0.37 Published 1996 Journal J. Biochem. Toxicol. Section Abstract Doc Link 9176741 Disease Relevance 0 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox