INT78749

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 9.23
Pain Relevance 16.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN10A) transmembrane transport (SCN10A)
Anatomy Link Frequency
nociceptors 6
sensory neurons 4
nerves 2
spine 2
DRG 2
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.8 92 100.00 Very High Very High Very High
sodium channel 77 100.00 Very High Very High Very High
tetrodotoxin 57 100.00 Very High Very High Very High
Nav1.9 4 100.00 Very High Very High Very High
Neuropeptide 39 99.86 Very High Very High Very High
nociceptor 12 99.84 Very High Very High Very High
Nav1.7 8 99.78 Very High Very High Very High
Nav1.6 7 99.30 Very High Very High Very High
neuralgia 2 99.20 Very High Very High Very High
Pain 101 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroma 10 99.76 Very High Very High Very High
Nociception 10 99.28 Very High Very High Very High
Stress 183 99.12 Very High Very High Very High
Pain 58 98.44 Very High Very High Very High
INFLAMMATION 23 98.16 Very High Very High Very High
Dyspareunia 16 98.08 Very High Very High Very High
Neuropathic Pain 23 97.48 Very High Very High Very High
Infection 7 97.16 Very High Very High Very High
Repression 2 95.20 Very High Very High Very High
Injury 23 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The voltage-gated sodium channels SNS/PN3 and NaN/SNS2 are expressed by sensory neurone that mediate pain, but their presence in the lumbar spine is unknown.
Gene_expression (expressed) of SNS in spine
1) Confidence 0.75 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0.15 Pain Relevance 0
The tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel SNS/PN3 and the newly discovered NaN/SNS2 are expressed in sensory neurones, particularly in nociceptors.
Gene_expression (expressed) of SNS in nociceptors associated with tetrodotoxin, nociceptor and sodium channel
2) Confidence 0.75 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 0.23 Pain Relevance 0.47
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN10A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
3) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.97
The human PN3 channel expressed in stable transfectants showed TTX-resistant inward currents with slow inactivation kinetics.
Gene_expression (expressed) of PN3 associated with tetrodotoxin
4) Confidence 0.71 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.23 Pain Relevance 1.01
We generated recombinant cell lines stably expressing the human PN1 and PN3 sodium channels in Chinese hamster ovary (CHO) cells using inducible expression vectors.
Gene_expression (expressing) of PN3 in ovary associated with sodium channel
5) Confidence 0.71 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.28 Pain Relevance 0.79
These results suggest that stable transfectants expressing the human PN1 and PN3 sodium channels will be useful tools to define subtype selectivity for sodium channel blockers.
Gene_expression (expressing) of PN3 associated with sodium channel
6) Confidence 0.71 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.17 Pain Relevance 0.94
Expression of hPN3 in Xenopus oocytes showed that this clone is a functional voltage-gated sodium channel.
Gene_expression (Expression) of hPN3 in oocytes associated with sodium channel
7) Confidence 0.70 Published 1998 Journal Pain Section Abstract Doc Link 9839820 Disease Relevance 0.23 Pain Relevance 0.54
In order to exclude differences of fitness, personality, and hormonal status, all known to affect SNS activation, we focussed on within-subject variability of SNS response.
Gene_expression (activation) of SNS
8) Confidence 0.67 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.29 Pain Relevance 0
The distribution of SNS/PN3 and SNS2/NaN sodium channels in injured human nerves indicates that they represent targets for novel analgesics, and could account for some differences in the development of neuropathic pain in infants.
Gene_expression (distribution) of SNS/PN3 in nerves associated with analgesic, neuropathic pain and sodium channel
9) Confidence 0.67 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10675548 Disease Relevance 0.71 Pain Relevance 0.43
The distribution of SNS/PN3 and SNS2/NaN sodium channels in injured human nerves indicates that they represent targets for novel analgesics, and could account for some differences in the development of neuropathic pain in infants.
Gene_expression (distribution) of SNS in nerves associated with analgesic, neuropathic pain and sodium channel
10) Confidence 0.65 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10675548 Disease Relevance 0.71 Pain Relevance 0.43
Sodium channel beta1 and beta2 subunits parallel SNS/PN3 alpha-subunit changes in injured human sensory neurons.
Gene_expression (parallel) of PN3 in sensory neurons associated with sodium channel
11) Confidence 0.65 Published 2001 Journal Neuroreport Section Title Doc Link 11234750 Disease Relevance 0.24 Pain Relevance 0.58
Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Gene_expression (express) of SNS in sensory neuron associated with neuropeptide and sodium channel
12) Confidence 0.65 Published 2002 Journal Spine Section Title Doc Link 11805657 Disease Relevance 0 Pain Relevance 0.24
OBJECTIVES: To demonstrate the presence of nerve fibers in lumbar spine structures and spine nerve roots, and to determine whether they express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Spec (whether) Gene_expression (express) of SNS in spine
13) Confidence 0.65 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0.18 Pain Relevance 0
Sodium channel beta1 and beta2 subunits parallel SNS/PN3 alpha-subunit changes in injured human sensory neurons.
Gene_expression (parallel) of SNS in sensory neurons associated with sodium channel
14) Confidence 0.65 Published 2001 Journal Neuroreport Section Title Doc Link 11234750 Disease Relevance 0.24 Pain Relevance 0.58
Stable expression and characterization of human PN1 and PN3 sodium channels.
Gene_expression (expression) of PN3 associated with neuropeptide and sodium channel
15) Confidence 0.62 Published 2003 Journal Recept. Channels Section Title Doc Link 14527872 Disease Relevance 0.29 Pain Relevance 1.12
Therefore, we analyzed SNS activation during the following stress tasks: Presentation of negative, positive, and – as a control – neutral affective pictures, Color-Word interference test (CWT), mental arithmetic under time limit, singing a song aloud, and giving a spontaneous talk.
Spec (analyzed) Gene_expression (activation) of SNS in SNS associated with stress
16) Confidence 0.59 Published 2008 Journal The Open Neurology Journal Section Abstract Doc Link PMC2577930 Disease Relevance 0.39 Pain Relevance 0
In previous studies it has been shown that task pacing (self-paced vs. automatically paced), task speed [16], and response mode affected SNS activation [17].
Gene_expression (activation) of SNS
17) Confidence 0.59 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.78 Pain Relevance 0.06
The tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states.


Gene_expression (expressed) of PN3 in nociceptors associated with pain, tetrodotoxin, nociceptor, sodium channel and nav1.8
18) Confidence 0.58 Published 2005 Journal BMC Oral Health Section Abstract Doc Link PMC1183220 Disease Relevance 0.24 Pain Relevance 1.22
The tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states.


Gene_expression (expressed) of SNS in nociceptors associated with pain, tetrodotoxin, nociceptor, sodium channel and nav1.8
19) Confidence 0.58 Published 2005 Journal BMC Oral Health Section Abstract Doc Link PMC1183220 Disease Relevance 0.24 Pain Relevance 1.22
The amino acid sequence of hPN3 is most closely related to the rat PN3/SNS sodium channels which are expressed primarily in the small neurons of rat DRGs.
Gene_expression (expressed) of SNS in neurons associated with sodium channel
20) Confidence 0.58 Published 1998 Journal Pain Section Abstract Doc Link 9839820 Disease Relevance 0.23 Pain Relevance 0.61

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