INT78766

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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 6.27
Pain Relevance 8.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
cortex 2
dorsal 1
amygdala 1
dorsal horn 1
dopamine neurons 1
Gria2 (Rattus norvegicus)
Gria2 - L504Y (1)
Pain Link Frequency Relevance Heat
Ventral tegmentum 306 99.84 Very High Very High Very High
Dopamine 132 99.68 Very High Very High Very High
Cannabinoid 162 99.12 Very High Very High Very High
tetrodotoxin 5 98.96 Very High Very High Very High
amygdala 15 98.40 Very High Very High Very High
Dorsal horn 24 97.68 Very High Very High Very High
Hippocampus 38 97.60 Very High Very High Very High
depression 282 96.92 Very High Very High Very High
Sciatic nerve 9 96.84 Very High Very High Very High
Morphine 18 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infarction 2 99.96 Very High Very High Very High
Diabetes Mellitus 180 98.60 Very High Very High Very High
Depression 282 96.92 Very High Very High Very High
Carpal Tunnel Syndrome 16 95.04 Very High Very High Very High
Toxicity 2 95.00 High High
INFLAMMATION 29 93.68 High High
Nervous System Injury 49 91.36 High High
Li-fraumeni Syndrome 48 91.32 High High
Hypoalagesia 1 88.68 High High
Inflammatory Pain 29 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant with the decrease in NSF, GluR2 and GluR3 were decreased and GluR1 was conversely increased in the PSD fraction 24 h after CFA injection.
Negative_regulation (decrease) of GluR2
1) Confidence 0.52 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18598260 Disease Relevance 0.52 Pain Relevance 0.75
Consistent results were obtained by double labeling experiments that revealed tyrosine hydroxylase and GluR1, GluR2/3, GluR4 or NMDAR1 immunoreactivity in the same sections.
Negative_regulation (revealed) of GluR2
2) Confidence 0.41 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840222 Disease Relevance 0.18 Pain Relevance 0.58
This decrease was accompanied by decreases in GluR2/3 AMPA receptor subunits.
Negative_regulation (decreases) of GluR2
3) Confidence 0.41 Published 2009 Journal Neuroscience Section Abstract Doc Link 19264110 Disease Relevance 0.73 Pain Relevance 0.30
The downregulation of GluR2 subunit may serve as a molecular switch leading to the formation of calcium-permeable AMPA receptors, which may enhance the toxicity of endogenous glutamate following a neurologic insult [44].
Negative_regulation (downregulation) of GluR2 associated with toxicity and glutamate
4) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.39 Pain Relevance 0.33
The amount of GluR2 was markedly increased in the crude cytosolic fraction and decreased in the crude membrane fraction from the ipsilateral L4–5 dorsal horn at 24 h (but not at 2 h) post-CFA injection.
Negative_regulation (decreased) of GluR2 in dorsal horn associated with dorsal horn
5) Confidence 0.34 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.50 Pain Relevance 0.51
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Negative_regulation (down-regulation) of GluR2 associated with tetrodotoxin
6) Confidence 0.31 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.34
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Negative_regulation (Decreased) of GluR2 in amygdala associated with hippocampus, amygdala and morphine
7) Confidence 0.30 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56
Because GluR2 is located in VTA dopamine neurons as shown above, these data further support our hypothesis that HU210 induces in vivo transient synaptic depression in VTA dopamine neurons.


Negative_regulation (located) of GluR2 in dopamine neurons associated with ventral tegmentum, dopamine and depression
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.74 Pain Relevance 0.88
Thus, blockade of HU210-elicited CPP by TAT-GluR2 may represent its disruptive effects on learning to associate cannabinoid exposure with environmental cues.
Negative_regulation (blockade) of GluR2 associated with cannabinoid
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.37 Pain Relevance 0.47
Previously, in cultured retinal neural cells, we found that the protein levels of GluR1 and GluR6/7 subunits decrease and GluR2 and KA2 subunits increase [29].
Negative_regulation (decrease) of GluR2 in neural
10) Confidence 0.29 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.55 Pain Relevance 0.34
In cortical regions destined to undergo infarction, GluR2 and NR1 messenger RNAs were preferentially reduced relative to the contralateral side (to 75+/-8.5% and 66+/-4.5%, respectively); GluR1, GluR3 and preproenkephalin messenger RNAs were unaltered.
Negative_regulation (reduced) of GluR2 associated with infarction
11) Confidence 0.27 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670452 Disease Relevance 0.58 Pain Relevance 0.28
This hypothesis receives additional support by our findings suggesting that a blockade of GluR2 endocytosis prior to cannabinoid exposure with TAT-GluR2 prevented synaptic depression in vivo, resulting in a blockade of cannabinoid-facilitated in vitro LTD induction in the VTA.
Negative_regulation (blockade) of GluR2 associated with ventral tegmentum, depression and cannabinoid
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.96 Pain Relevance 1.17
Consistent with the observed deficit in trafficking, GluA2 L504Y is deficient in dimer-to-tetramer transition when expressed in HEK cells using a DOX-dependent expression system [23].
Negative_regulation (deficient) of GluA2 L504Y (L504Y)
13) Confidence 0.23 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
As described earlier, GluA2 L504Y, the non-desensitizing point mutant, has significantly decreased cell surface expression compared to the wild-type GluA2.
Negative_regulation (decreased) of GluA2
14) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
Similar tetrameric arrangement of the GluA2 NTD was also observed in the crystal packing of GluA2 NTD from Gouaux’s laboratory [72].
Negative_regulation (packing) of GluA2
15) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.09
In corticosterone-treated cells the punctate synaptic SEP-GluR2 fluorescence started to decrease immediately on exposure to NMDA with a time course similar to the decrease in diffuse non-synaptic SEP-GluR2 (Figure 4B, D).
Negative_regulation (decrease) of GluR2
16) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.21 Pain Relevance 0.10
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Negative_regulation (Decreased) of GluR2 in dorsal associated with hippocampus, amygdala and morphine
17) Confidence 0.10 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56
While they do report significant decreases in GluR2 and GluR3 subunits, there are no significant changes in GluR1 expression (see Supplementary Material Figure 4a; Wright et al., 2008).
Negative_regulation (decreases) of GluR2
18) Confidence 0.09 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.10 Pain Relevance 0.13
In the present experiments, we have quantified the immunohistochemical staining of GluR1 and GluR2/3 AMPA receptor subunits in deprived cortex 1?
Negative_regulation (staining) of GluR2 in cortex
19) Confidence 0.09 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.17 Pain Relevance 0.33
The increase in Glur1 staining intensity and concomitant decrease in GluR2/3 staining intensity found here in deprived cortex 1?
Negative_regulation (decrease) of GluR2 in cortex
20) Confidence 0.08 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.06 Pain Relevance 0.13

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