INT78769

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.22
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
cerebellar granule cell 1
grey matter 1
brain 1
pore 1
hippocampus 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 248 100.00 Very High Very High Very High
Glutamate receptor 36 100.00 Very High Very High Very High
Hippocampus 63 99.96 Very High Very High Very High
long-term potentiation 235 99.84 Very High Very High Very High
withdrawal 27 99.60 Very High Very High Very High
Anterior cingulate cortex 8 99.50 Very High Very High Very High
Inflammation 76 99.40 Very High Very High Very High
butorphanol 18 99.16 Very High Very High Very High
Intracerebroventricular 2 98.42 Very High Very High Very High
Thalamus 6 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 78 99.40 Very High Very High Very High
Diabetes Mellitus 87 98.92 Very High Very High Very High
Hyperalgesia 39 95.08 Very High Very High Very High
Nociception 81 94.68 High High
Depression 294 94.00 High High
Drug Dependence 2 90.24 High High
Frailty 12 86.96 High High
Stress 68 83.76 Quite High
Cognitive Disorder 9 83.44 Quite High
Obesity 1 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Continuous intracerebroventricular (i.c.v.) infusion with butorphanol (26 nmol/microl/h) resulted in significant modulations in the NRI, NR2A, and NR2B mRNA levels.
Regulation (modulations) of NR2A associated with butorphanol and intracerebroventricular
1) Confidence 0.58 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.25
No changes of NR1, NR2A, NR2C subunit mRNA in the cerebellar granule cell layer were observed in either butorphanol tolerant or withdrawal rats.
Neg (No) Regulation (changes) of NR2A in cerebellar granule cell associated with butorphanol and withdrawal
2) Confidence 0.58 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.78
These data indicated no significant changes in NR1 splice variants or NR2A protein (Figures 6 and 7).
Neg (no) Regulation (changes) of NR2A protein
3) Confidence 0.53 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.71 Pain Relevance 0.25
Immunoreactivity for NMDAR2A/B, mGluR1alpha. and mGluR2/3 was detected in the neuropil of the substantia nigra pars reticulata.
Regulation (Immunoreactivity) of NMDAR2A in neuropil associated with substantia nigra
4) Confidence 0.44 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840222 Disease Relevance 0.17 Pain Relevance 0.50
METHODS: The effect of ammonia was studied on alpha1beta2 and alpha1beta2gamma2s gamma-amino butyric acid type A, alpha1 glycine, and NR1/NR2A N-methyl-D-aspartate receptors, and the two-pore domain potassium channel TRESK.
Regulation (effect) of NR2A in pore
5) Confidence 0.44 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17513636 Disease Relevance 0 Pain Relevance 0
Studies in some other brain regions than hippocampus, such as anterior cingulate cortex (ACC), also showed that both NR2A- and NR2B-type NMDARs contributed to LTP [21].
Regulation (contributed) of NR2A in brain associated with long-term potentiation, hippocampus and anterior cingulate cortex
6) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.36 Pain Relevance 0.73
The inflammation did not produce phosphorylation of serines on NR2 subunits or phosphorylation of threonine and tyrosine residues on either NR1 or NR2 subunits.
Regulation (residues) of NR2 associated with inflammation
7) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.95 Pain Relevance 0.69
In this case, NR2A- and NR2B-type receptors were unable to substitute for each other but functioned as individual, antagonistic controllers of the polarity of the synaptic change.
Regulation (controllers) of NR2A
8) Confidence 0.34 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.56 Pain Relevance 0.52
As shown in Figure 10A–D, both leupeptin (100 µM) and calpeptin (100 µM) completely prevented UCB-induced down-regulation of NR2A and NR2B subunit proteins.
Regulation (regulation) of NR2A
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.06 Pain Relevance 0.07
In the hippocampus, immunoreactivity for NR2A and NR2B subunits are reduced in diabetic rats.
Regulation (immunoreactivity) of NR2A in hippocampus associated with diabetes mellitus and hippocampus
10) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.97 Pain Relevance 0.39
Analysis of postsynaptic densities (PSDs) by immunoblotting revealed no changes in the glutamate receptor subunits GluR1, NR1, NR2A/B, mGluR1alpha nor in the neurotrophin receptor p75(NTR).
Neg (no) Regulation (changes) of NR2A associated with glutamate receptor
11) Confidence 0.26 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.56
Although NR1 puncta were present throughout the grey matter, NR2A was concentrated in laminae III-IV and NR2B in laminae I-II.
Regulation (concentrated) of NR2A in grey matter
12) Confidence 0.25 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15610162 Disease Relevance 0.07 Pain Relevance 0.53
An analysis of NR1 and NR2 protein expression demonstrated no change in the levels of NR1 splice variants or NR2A following the inflammation.
Neg (no) Regulation (change) of NR2A associated with inflammation
13) Confidence 0.20 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.72 Pain Relevance 0.64
According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A, and NR2B, induced by diverse types of reinforcers, we chose NR2B subunit as the target of research.
Regulation (changes) of NR2A associated with nmda receptor
14) Confidence 0.20 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16631172 Disease Relevance 0.17 Pain Relevance 0.66
However, no change in the levels of NR1, NR2A, and NR2B subunits was observed in slices treated with 1 µM UCB for 24 h.
Neg (no) Regulation (change) of NR2A
15) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.36
NMDA receptors themselves are subject to regulation by phosphorylation on their NR1, NR2A and NR2B subunits [58-60].
Regulation (regulation) of NR2A associated with nmda receptor
16) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.48 Pain Relevance 0.36

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