INT78773

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.76
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)
Anatomy Link Frequency
astrocytes 2
plasma 1
chondrocytes 1
superior 1
internal 1
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 316 99.76 Very High Very High Very High
antagonist 12 98.34 Very High Very High Very High
Inflammatory response 24 97.04 Very High Very High Very High
cytokine 59 96.32 Very High Very High Very High
Angina 8 96.12 Very High Very High Very High
rheumatoid arthritis 5 86.40 High High
backache 1 81.12 Quite High
Sciatica 1 80.24 Quite High
Kinase C 5 69.36 Quite High
Potency 5 56.08 Quite High
Disease Link Frequency Relevance Heat
Stroke 8 100.00 Very High Very High Very High
INFLAMMATION 359 99.76 Very High Very High Very High
Osteoarthritis 6 99.70 Very High Very High Very High
Skin Cancer 8 99.34 Very High Very High Very High
Acute Coronary Syndrome 36 99.28 Very High Very High Very High
Disease 333 97.08 Very High Very High Very High
Myocardial Infarction 33 96.64 Very High Very High Very High
Cv General 3 Under Development 8 96.12 Very High Very High Very High
Inflammatory Bowel Disease 80 95.88 Very High Very High Very High
Death 12 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent lack of sPLA2-IIA immunoreactivity in microglial cells seems to be in agreement with our earlier study with a rat stroke model in which up-regulation of sPLA2-IIA immunoreactivity was observed primarily in reactive astrocytes but not in microglia [34].
Regulation (immunoreactivity) of sPLA2 in astrocytes associated with stroke
1) Confidence 0.61 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.69 Pain Relevance 0.28
To further demonstrate expression and regulation of sPLA2-IIA in astrocytes, human astrocytes cultured from superior frontal gyrus of post-mortem AD brains were treated with A?
Regulation (regulation) of sPLA2 in superior associated with disease
2) Confidence 0.61 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.61 Pain Relevance 0.10
Interestingly, total sPLA2-activity had a better prognostic value than the sPLA2-IIA antigen level.
Regulation (value) of sPLA2-IIA
3) Confidence 0.59 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.26 Pain Relevance 0.13
We postulated that the addition of an AT1-receptor antagonist to the standard secondary prevention therapy with a statin might exert additional effects on LDL oxidation and sPLA2-IIA.
Spec (might) Regulation (effects) of sPLA2-IIA associated with antagonist
4) Confidence 0.59 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.58 Pain Relevance 0.09
The apparent lack of sPLA2-IIA immunoreactivity in microglial cells seems to be in agreement with our earlier study with a rat stroke model in which up-regulation of sPLA2-IIA immunoreactivity was observed primarily in reactive astrocytes but not in microglia [34].
Regulation (regulation) of sPLA2 in astrocytes associated with stroke
5) Confidence 0.45 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.78 Pain Relevance 0.33
Eight genes (CYLD, DAF, DKFZp547A023, MUC1, OCLN, PLA2G2A, TIMP1, and ZCCHC4;Table 5) were significantly differentially regulated between normal controls and inflamed DC, and the direction of change was the same as that observed in IBD.
Regulation (regulated) of PLA2G2A associated with inflammatory bowel disease and skin cancer
6) Confidence 0.35 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.38 Pain Relevance 0.04
These procedures produced sPLA2-IIA immunoreactivity in dark blue color and GFAP in brown color.
Regulation (immunoreactivity) of sPLA2
7) Confidence 0.27 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.24 Pain Relevance 0
Only cell-associated (disc cells, hyaline cartilage chondrocytes) sPLA2 and cPLA2 immunoreactivity could be observed.
Regulation (immunoreactivity) of sPLA2 in chondrocytes associated with osteoarthritis
8) Confidence 0.27 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.59 Pain Relevance 0.16
Mallat and colleagues (2007) also evaluated the prognostic importance of plasma sPLA2-IIA levels and enzyme activity across the entire spectrum of ACS by recruiting patients from the Global Registry of Acute Coronary Events (GRACE).
Regulation (importance) of sPLA2-IIA in plasma associated with acute coronary syndrome
9) Confidence 0.26 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.18 Pain Relevance 0.22
The prognostic value of sPLA2-IIA in patients with acute coronary syndromes (ACS) was first described in a study of patients with unstable angina by Kugiyama and colleagues (2000).
Regulation (value) of sPLA2-IIA associated with acute coronary syndrome and angina
10) Confidence 0.26 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.06 Pain Relevance 0.26
Moreover, we specifically evaluated the expression of secretory type IIa phospholipase A2 (sPLA2-IIa) by western blot and qualified the content alteration of sPLA2-IIa, using same approach with SBTI as an internal standard.
Regulation (alteration) of sPLA2-IIa in internal
11) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 0.60 Pain Relevance 0
The modulation of sPLA2 and/or cPLA2 activity is important in controlling the inflammatory process.
Regulation (modulation) of sPLA2 associated with inflammation
12) Confidence 0.11 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.80 Pain Relevance 0.31

General Comments

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