INT78774

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.39
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLA2G6) cytoplasm (PLA2G6)
Anatomy Link Frequency
endothelial cells 1
hyaline cartilage 1
paneth cells 1
PLA2G6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 566 99.76 Very High Very High Very High
Calcium channel 85 98.16 Very High Very High Very High
bradykinin 16 96.96 Very High Very High Very High
Inflammatory marker 12 96.88 Very High Very High Very High
cytokine 202 94.72 High High
backache 1 72.28 Quite High
Sciatica 1 71.40 Quite High
addiction 2 64.48 Quite High
rheumatoid arthritis 12 35.44 Quite Low
Potency 8 28.00 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 10 99.84 Very High Very High Very High
INFLAMMATION 692 99.76 Very High Very High Very High
Diabetes Mellitus 58 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 2 99.40 Very High Very High Very High
Atherosclerosis 56 98.76 Very High Very High Very High
Hypoxia 2 96.56 Very High Very High Very High
Otitis Media With Effusion 184 96.40 Very High Very High Very High
Endotoxemia 1 96.20 Very High Very High Very High
Death 11 95.76 Very High Very High Very High
Injury 32 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both PLA2 enzymes were predominantly present in hyaline cartilage cells (sPLA2: 16/53, cPLA2: 5/53), being less commonly observed in disc cells (sPLA2: 6/53, cPLA2: 3/53).
Gene_expression (present) of PLA2 in hyaline cartilage associated with osteoarthritis
1) Confidence 0.61 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.56 Pain Relevance 0.18
IPLA2 were detected with a polyclonal anti-iPLA2 (dilution1?
Gene_expression (detected) of IPLA2
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
Displacement of CaM leads to iPLA2 activation and production of lysophospholipids inducing the opening of SOCs [36], the entry of Ca2+ and the release of innate immune factors among a long list of proteins (Figure 8C and Figures S1 and S2).
Gene_expression (production) of iPLA2 associated with calcium channel
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.08 Pain Relevance 0.05
Gel electrophoresis and Western-blot analysis of iPLA2 in PMNs
Gene_expression (analysis) of iPLA2
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
IPLA2 were detected with a polyclonal anti-iPLA2 (dilution1?
Gene_expression (dilution1) of iPLA2
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
Detection of iPLA2 in PMNs and iPLA2 activity assay
Gene_expression (Detection) of iPLA2
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
Phospholipase A2 (PLA2), the enzyme that cleaves phospholipids producing lysophospholipids and free fatty acids, was originally identified as an intracellular protein involved in cell signaling and in the production of free fatty acids, such as arachidonic acid.36 It is known that PLA2 plays an important role in the inflammation process.
Gene_expression (production) of PLA2 associated with inflammation
7) Confidence 0.38 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.63 Pain Relevance 0.32
Cyclooxygenase, lipoxygenase, and PLA2 are discussed as AA-dependent pathway proteins by polyphenols, whereas NOS, NF-?
Gene_expression (discussed) of PLA2
8) Confidence 0.38 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.68 Pain Relevance 0.27
The secreted form of PLA2-II, responsible for the extracellular production of PAF, is expressed by many cell types including intestinal paneth cells and its release is triggered by hypoxia, endotoxemia, and trauma among other stimuli.
Gene_expression (expressed) of PLA2 in paneth cells associated with endotoxemia, hypoxia and injury
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.18 Pain Relevance 0.07
In addition, tentacle extracts from Aurelia showed phospholipase A2 (PLA2) activity [62], which is known to be a major contribution to animal venoms and to cause several pharmacological and toxicological effects such as neurotoxicity, myotoxicity and haemolysis; PLA2 enzymes are present in several Cnidaria [112], both in nematocytes and in tissues [113], may be involved in physiological cell membrane lipid metabolism, in the irritation at the stinging site and in the enhancement of the haemolytic activity and can act alone or together with other proteins [114].
Gene_expression (present) of PLA2 associated with drug induced neurotoxicity
10) Confidence 0.20 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866479 Disease Relevance 0.16 Pain Relevance 0.03
The patients in which LP PLA2 levels were in the highest quintile had almost twice the risk of those in whom they were in the lowest quintile [85].
Gene_expression (levels) of PLA2
11) Confidence 0.19 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.95 Pain Relevance 0.08
They found that in these patients LP PLA2 levels had a strong, positive association with the development of coronary events i.e., myocardial infaction, cardiovascular death or revascularization procedure, which was not confounded by other risk factors.
Gene_expression (levels) of PLA2 associated with death
12) Confidence 0.17 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.73 Pain Relevance 0.09
LP PLA2 levels have show a significant and positive correlation with CRP levels, reflecting the possible relation of LP PLA2 with inflammatory activity in atherosclerotic arteries [83].
Spec (possible) Gene_expression (relation) of PLA2 associated with inflammation and atherosclerosis
13) Confidence 0.17 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.85 Pain Relevance 0.09
LP PLA2 levels have show a significant and positive correlation with CRP levels, reflecting the possible relation of LP PLA2 with inflammatory activity in atherosclerotic arteries [83].
Gene_expression (levels) of PLA2 associated with inflammation and atherosclerosis
14) Confidence 0.17 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.86 Pain Relevance 0.09
The synthesis of PLA2 activating protein is induced in endothelial cells by IL-1, TNF, LTD4, and bradykinin (147, 148).
Gene_expression (synthesis) of PLA2 in endothelial cells associated with bradykinin
15) Confidence 0.13 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.85 Pain Relevance 0.25
enhances PLA2 expression (237).
Gene_expression (expression) of PLA2
16) Confidence 0.10 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.86 Pain Relevance 0.05

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