INT78809

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.89
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADK) small molecule metabolic process (ADK) nucleus (ADK)
kinase activity (ADK)
Anatomy Link Frequency
central nervous system 1
ADK (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 13 100.00 Very High Very High Very High
Central nervous system 1 99.22 Very High Very High Very High
cINOD 4 97.94 Very High Very High Very High
Analgesic 4 96.60 Very High Very High Very High
fibrosis 1 91.84 High High
anesthesia 1 86.44 High High
Pain management 1 75.00 Quite High
depression 1 71.96 Quite High
Pain 10 69.08 Quite High
allodynia 1 54.80 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 9 94.16 High High
Arrhythmias 2 Under Development 5 93.36 High High
Fibrosis 1 91.84 High High
Mitral Valve Insufficiency 1 88.84 High High
Pain 8 75.00 Quite High
INFLAMMATION 1 73.24 Quite High
Depression 1 71.96 Quite High
Stress 2 70.48 Quite High
Neuropathic Pain 1 54.80 Quite High
Hyperalgesia 1 52.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of adenosine kinase elevate adenosine to levels that activate nearby adenosine receptors and produce a wide variety of therapeutically beneficial activities.
Negative_regulation (Inhibitors) of adenosine kinase associated with adenocard
1) Confidence 0.34 Published 1998 Journal Biochemistry Section Abstract Doc Link 9843365 Disease Relevance 0 Pain Relevance 0.41
Future directions for analgesic research are many, but include the use of nitric oxide (NO) NSAIDs; the possibility of decreasing NO in the central nervous system; inhibiting the vanilloid receptor-1; inhibiting adenosine kinase; activating PPARgamma; and mimicking superoxide dismutase, as well as combinations of complementary-acting analgesics.
Negative_regulation (inhibiting) of adenosine kinase in central nervous system associated with adenocard, analgesic, cinod and central nervous system
2) Confidence 0.15 Published 2001 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 11695256 Disease Relevance 0.78 Pain Relevance 1.31
Profound deficits in atrial bioenergetics were present with reduced activities of the phosphotransfer enzymes CK and AK, depletion of high-energy phosphates (ATP and creatine phosphate), and reduction of cellular energetic potential (ATP-to-ADP and creatine phosphate-to-Cr ratios).
Negative_regulation (reduced) of AK
3) Confidence 0.07 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12626329 Disease Relevance 1.11 Pain Relevance 0.13

General Comments

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