INT78809

Context Info Confidence 0.34 First Reported 1998 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.89 Pain Relevance 1.85

cytosol (ADK) small molecule metabolic process (ADK) nucleus (ADK) kinase activity (ADK)

Anatomy Link Frequency central nervous system 1 ADK (Homo sapiens)

Pain Link Frequency Relevance Heat adenocard 13 100.00 Central nervous system 1 99.22 cINOD 4 97.94 Analgesic 4 96.60 fibrosis 1 91.84 anesthesia 1 86.44 Pain management 1 75.00 depression 1 71.96 Pain 10 69.08 allodynia 1 54.80

Disease Link Frequency Relevance Heat Heart Rate Under Development 9 94.16 Arrhythmias 2 Under Development 5 93.36 Fibrosis 1 91.84 Mitral Valve Insufficiency 1 88.84 Pain 8 75.00 INFLAMMATION 1 73.24 Depression 1 71.96 Stress 2 70.48 Neuropathic Pain 1 54.80 Hyperalgesia 1 52.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibitors of adenosine kinase elevate adenosine to levels that activate nearby adenosine receptors and produce a wide variety of therapeutically beneficial activities.

Negative_regulation (Inhibitors) of adenosine kinase associated with adenocard

1) Confidence 0.34 Published 1998 Journal Biochemistry Section Abstract Doc Link 9843365 Disease Relevance 0 Pain Relevance 0.41

Future directions for analgesic research are many, but include the use of nitric oxide (NO) NSAIDs; the possibility of decreasing NO in the central nervous system; inhibiting the vanilloid receptor-1; inhibiting adenosine kinase; activating PPARgamma; and mimicking superoxide dismutase, as well as combinations of complementary-acting analgesics.

Negative_regulation (inhibiting) of adenosine kinase in central nervous system associated with adenocard, analgesic, cinod and central nervous system

2) Confidence 0.15 Published 2001 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 11695256 Disease Relevance 0.78 Pain Relevance 1.31

Profound deficits in atrial bioenergetics were present with reduced activities of the phosphotransfer enzymes CK and AK, depletion of high-energy phosphates (ATP and creatine phosphate), and reduction of cellular energetic potential (ATP-to-ADP and creatine phosphate-to-Cr ratios).

Negative_regulation (reduced) of AK

3) Confidence 0.07 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12626329 Disease Relevance 1.11 Pain Relevance 0.13

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